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News Release 1-Sep-2025 Study Reveals Details of Overactive Immune System in Patients with Chronic Fatigue Syndrome (ME/CFS) Peer-Reviewed Publication Columbia University's Mailman School of Public Health Patients with chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) have heightened innate immune responses to bacteria, viruses and fungi. While these responses are essential to fight infection, they can cause damage when unchecked. Led by researchers at the Center for Infection and Immunity (CII) at Columbia University Mailman School of Public Health with a multicenter team of leading ME/CFS researchers, the new study reveals molecular-level details into the syndrome’s lasting effects on inflammation and immune response that could inform the development of targeted therapeutic interventions to reduce symptoms of ME/CFS and other postinfectious syndromes such as post-treatment Lyme disease and Long COVID. Study findings are published in the journal npj Metabolic Health and Disease.

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New US News Release

Study Reveals Details of Overactive Immune System in Patients with Chronic Fatigue Syndrome (ME/CFS)

www.eurekalert.org/news-release...

"Patients with [ME/CFS] have heightened innate immune responses to bacteria, viruses & fungi"

#ChronicFatigueSyndrome #MEcfs #CFS #PwME
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Columbia University: 'Study Reveals Details of Overactive Immune System in Patients with Chronic Fatigue Syndrome (ME/CFS)'

“These results suggest that specific intracellular pathways correlate with symptoms,” adds Amit Ranjan, PhD, co-first author

www.eurekalert.org/news-release...

Long COVID could hold key to ME/CFS, MS La Trobe to research post-viral infections with $3m in NHMRC funding.

Long COVID could hold key to ME/CFS, MS.

"Long COVID could provide vital clues to uncover the cause of other life-limiting post-viral infections such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Multiple Sclerosis at a new research centre to be established at La Trobe University"

Distinct white matter alteration patterns in post-infectious and gradual onset chronic fatigue syndrome revealed by diffusion MRI - Scientific Reports Scientific Reports - Distinct white matter alteration patterns in post-infectious and gradual onset chronic fatigue syndrome revealed by diffusion MRI

Distinct white matter alteration patterns in post-infectious and gradual onset #ME/CFS revealed by diffusion MRI

These findings align with the diverse symptomatology of ME/CFS, including motor disturbances. Several studies have also reported the exclusively increased AD in other neurological

Sluta ignorera ME-sjuka - Altinget Uppskattningsvis lever minst 40 000 personer i Sverige med ME. Ändå finns det ingen nationell struktur för långsiktig vård och stöd. Det skriver Lollo Romlin, vice ordförande Riksförbundet för ME-pati...

Debattartikel om ME i @altingetse.bsky.social idag. Tack!

www.altinget.se/vard/artikel...

Our latest News in Brief post has headlines and links to further reading for #MECFS, #LongCovid, and related news, advocacy and research for the week of July 28 - Aug 3.

Topics:
News, advocacy and articles
Coming events
Research news and commentary
& Published research […]

Replicated blood-based biomarkers for myalgic encephalomyelitis not explicable by inactivity | EMBO Molecular Medicine imageimageThere are no cellular or molecular biomarkers diagnostic of myalgic encephalomyelitis (also known as chronic fatigue syndrome [ME/CFS]). We find hundreds of blood-based traits are different,...

Beentjes et al., comparison of traits for people with #MECFS and controls in UK Biobank data. Hundreds of traits differed between cases and controls, but single traits couldn’t distinguish case from control. The results cannot be explained by inactivity. www.embopress.org/doi/full/10....

Wenzhong Xiao, PhD, with short black hair wearing a light blue collared shirt, smiling slightly against a dark background. Above his image is a teal-blue box with the word “UPDATE” in white capital letters. At the bottom of the image, a dark blue banner reads: “Patient-Reported Treatment Outcomes in ME/CFS and Long COVID.”

Update: Patient-Reported Treatment Outcomes in #MECFS and #LongCOVID

After undergoing the peer-review process, the manuscript was today published in PNAS. Read the full publication 👉 ow.ly/3EQm50WmwCw.

🔗 Summary: ow.ly/Vmx850WmwCr.

"Many of us ... have had a tremendous amount of loss after we get our diagnosis... o, A loss of identity, A loss of the skills that we © had, (POW The brain we used, Our communications style, ODThe relationships that ywe've had, The ability to do work..., 8 e' ' 8 To do volunteer work..., To have a child, ,_,C7 t--='' To have a pet. These things have a serious impact" -.4km Weaver et al. Frontiers in Health Services. (2025) RESEARCH UK INFORM. INFLUENCE. INVEST. SCO36942

From @meresearchuk.bsky.social

Researchers in America have found that including people with lived experience of #MECFS, #longCOVID, or other post-acute infection syndromes (PAIS) in an education program for health professionals generally improved the care patients received.Read more: bit.ly/3ZZkZrD

1) A new genetic study from Australia.

Although it had only 77 patients, they found significant associations between ME/CF and genes that belong to the Neuroblastoma Breakpoint Family encoding Olduvai (DUF1220) domains (NBPF1, NBPF10, NBPF16).

News Immune Markers Help Identify Subgroups of ME/CFS Patients Proteins involved in neuroinflammation found in the cerebrospinal fluid could help researchers better diagnose and treat chronic fatigue syndrome. Written byShelby Bradford, PhD Jul 2, 2025 | 4 min read Photo of a woman with straight dark hair looking fatigued lying in bed with a grey blanket covering her. People with ME/CFS experience extreme fatigue and concentration difficulties. However, researchers suspect the underlying causes could be distinct. Image credit:©iStock, PeopleImages

On US/Swedish research:

"Immune Markers Help Identify Subgroups of ME/CFS Patients: Proteins involved in neuroinflammation found in the cerebrospinal fluid could help researchers better diagnose and treat chronic fatigue syndrome"

www.the-scientist.com/profiling-im...

#MEcfs #CFS #PwME

Home The University of Edinburgh News Scale of how ME/CFS affects blood revealed Scale of how ME/CFS affects blood revealed People with ME/CFS have significant differences in their blood compared with healthy individuals, a new study reveals, suggesting a path towards more reliable diagnosis of the long-term debilitating illness. White male lying in a bed looking tired The largest ever biological study of ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) has identified consistent blood differences associated with chronic inflammation, insulin resistance, and liver disease. Significantly, the results were mostly unaffected by patients’ activity levels, as low activity levels can sometimes hide the biological signs of illness, experts say.

News release:
"People with ME/CFS have significant differences in their blood compared with healthy individuals, a new study reveals, suggesting a path towards more reliable diagnosis of the long-term debilitating illness"

www.ed.ac.uk/news/scale-o...

#MEcfs #CFS #PwME

Screenshot of list of authors, their affiliations and the introduction section

New:
Unwilling or unable? Interpreting effort task performance in myalgic encephalomyelitis/chronic fatigue syndrome

www.frontiersin.org/journals/psy...

#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME

Yay! There is not one reason to buy a tesla. I would like to see 0 sold cars.

Chronic Denial A debunked theory about chronic fatigue syndrome is being recycled to explain Long Covid—with troubling results.

Dr. David Tuller. Chronic Denial: “The psychosomatic interpretation of Long Covid recycles a discredited framework, one that has repeatedly failed patients with #MECFS.”
www.openmindmag.org/articles/goi...

Oh it was a executive order forbidding words to be used. Women was one of them.

Patients with severe ME/CFS need hope in the form of evidence-based interventions, not opinions.

We do not need false hope.

www.bmj.com/content/389/...

Rising Cost of Long COVID and ME/CFS Die steigenden Kosten von Long COVID und ME/CFS in DeutschlandEin neuer Bericht von Risklayer und der ME/CFS Research Foundation modelliert e

The costs of ME and longcovid. A report from Germany of the costs associated with the two illnesses.

mecfs-research.org/en/costrepor...

The risk of blaming patients for their lack of recovery

A rapid response from Michiel Tack to the BMJ on their recent Opinion piece on #ME from Miller et al.

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where...

New PLRC-funded work out from Rob Wust & team!

Skeletal muscles in #LongCovid and ME *differ* from skeletal muscles induced by bedrest.

LC and ME is not deconditioning! 1/
www.medrxiv.org/content/10.1...

Today is the international ME day.

Please spread knowledge so that we can get health care, care, research and support.

We do not want to suffer any more!

#MECFS is a debilitating, neurological illness. Severe cases are like torture around the clock: pain, malaise, insomnia, sensitivity to sound, touch, and light. Some believe it’s just fatigue, but that doesn't even come close to describing the reality of ME/CFS. #MEAwarenessHour

People should know about ME/CFS, just as MS, Parkinson’s, and diabetes are common knowledge. When ME patients disclose their illness, they are often met with comments such as “I’m also tired”. Patients shouldn’t have to face such ignorance—it’s a severe illness. #MEAwarenessHour

Me too, went from mild to severe in one day due to training recommended by health care.

Sadly very true. Happened to me and 30 years later I’m still suffering and much worse than I was initially (I was undiagnosed for 5 years).

#MEcfs #SevereME

Image of a woman running Thousands demand withdrawal of review article recommending exercise therapy for chronic fatigue syndrome The decision to abandon a process to re-evaluate a review recommending exercise therapy for chronic fatigue syndrome (ME/CFS) has reignited calls for the article to be withdrawn. The 2019 version of the Cochrane Library review, “Exercise therapy for chronic fatigue syndrome,” has accumulated 67 citations, according to Clarivate’s Web of Science.

Thousands demand withdrawal of review article recommending exercise therapy for chronic fatigue syndrome

Links in image:
www.cochranelibrary.com/cdsr/doi/10....

retractionwatch.com/2025/01/23/t...

Screenshot from the AMMES May email newsletter

#MEcfs #CFS

#MedSky
Invasive cardiopulm exercise testing (iCPET) at Brigham & Women’s finds people w/ #MECFS & #longCovid have symptomatic ⬇️ aerobic capacity at peak exercise due to preload insufficiency & impaired systemic O2 extraction, latter c/w peripheral L➡️R shunt &/or limb skel muscle dysfunction. /1

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where...

Again for those in the back:
👏🏼 PEM 👏🏼 is 👏🏼 NOT 👏🏼 deconditioning

Symptoms associated with effort expenditure in #LongCOVID, #MECFS and other energy limiting illnesses are physiological, not “preferential”

Thanks to @RobWust for this incredible work.

www.medrxiv.org/content/10.1...

“Skeletal muscle properties in #LongCOVID and #ME/CFS differ from those induced by bed rest”

Objective science debunking deconditioning theories! 💥 🎤

@patientled.bsky.social

www.medrxiv.org/content/10.1...

Heart Preload Failure - Open Medicine Foundation This study aims to evaluate different explanations of preload failure in ME/CFS patients.

Heart Preload Failure www.omf.ngo/heart-preloa... via @openmedf.bsky.social #ME/CFS