Find out more about this exciting initiative from Biology Open in this editorial and the accompanying preprint www.biorxiv.org/content/10.1...
25.03.2025 11:48
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Find out more about this exciting initiative from Biology Open in this editorial and the accompanying preprint www.biorxiv.org/content/10.1...
Great work, congrats !!!!
Very nice, congrats
How does a neuron get its activity? 👀
Check out our latest preprint, where we tracked the activity of the same neurons throughout early postnatal development: www.biorxiv.org/content/10.1...
see 🧵 (1/?)
📣 We’re hiring! 🚨 PhD position to study SOCIAL CODING in mouse S1 and mPFC using longitudinal INSCOPIX recordings from WT and socially amnesic mice during social tasks! Strong data analysis & computational modeling component. Co-sup with @lorifonto.bsky.social & Leo Guignard
tinyurl.com/3hndp7uj
More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025
Looking for a place to start your lab, or a join an existing team as a permanent researcher? My Institute, the INP in Marseille, has multiple open positions: associate professor, lecturer, group leader. Check more here, happy to answer questions by email or DMs! euraxess.ec.europa.eu/jobs/304107
#neuroscience #neuroskyence
Fantastically detailed work by @antoinedechevigny.bsky.social & collaborators, giving us insights into molecular mechanisms orchestrating the connections between glutamatergic and
GABAergic neurons throughout cortical maturation (in mice). Great work on brain wiring 🧪🧬🧠
[+ nice 🧵👇]
🚀 Think all white matter (WM) astrocytes are the same? Think again! 🌟 Our latest research reveals striking regional differences that challenge existing views on astrocyte diversity and function. 🧠
www.nature.com/articles/s41...
Very nice work
Excited to announce multiple #PhD & #Postdoc positions opening in my lab over the next three years as part of the #ERC Starting grant DIVERSE! Reposts appreciated 😊 #neuroscience #neuroskyence
Very nice and important paper 👏
Thank you @cedricboeckx.bsky.social for the nice comment !!!!
Very nice paper 👏
"Developmental Timing Across Species"
@embo.org Workshop organised by @trayon.bsky.social @bassemh.bsky.social @mdiazcuadros.bsky.social @vanderhaeghenp2.bsky.social
📅6-9 May 2025
📍Paris
Submit abstract and register by 1 April:
thenode.biologists.com/developmenta...
#EvoDevoTempo
www.nature.com/articles/s41... awesome new work out today! From the Lee lab in the intramural research program at NIMH!
Exciting developments ahead in LR predictions with developmental spatial transcriptomics and a focus on non-neuronal cells !!!!
All that, and more! Big thanks to Rémi Mathieu and
@ltelley.bsky.social who made everything go !!!! And the other collaborators of course
Thanks to funding bodies: @agencerecherche.bsky.social, @EU_H2020, @FRM_officiel, @AgenceRecherche, @Inserm, @jeromelejeune.bsky.social, @frcneurodon, @Rotary
9/9 These findings underscore the power of large-scale transcriptional profiling to unravel fundamental molecular mechanisms driving cortical circuit assembly.
8/9 This atlas not only corroborated known interactions but also enabled the discovery of novel regulators, identifying 2 cadherin superfamily members as key mediators of perisomatic inhibition in deep vs superficial layer excitatory neurons by parvalbumin-expressing basket cells
7/9 Our LR atlas validated key interactions like CBLN4, which drives inhibitory synapse formation on GlutNs. It showed that CBLN4 exp is specific to Sst|L2/3-L5 fan-MCs, and predicted NEO1 as its primary receptor in the cortex. Proximity ligation assays confirmed this prediction
6/9 LRs linked to autism and epilepsy were widely used in the somatosensory cortex (examined here), while LRs linked to schizophrenia and intellectual disabilities may affect interactions beyond this area.
5/9 While neuron-pair specific LRs were rare, most LRs were shared by a relatively small subset of possible neuron-pairs (<100 out of 729 cell pairs). Ultimately, specificity arose from the unique combinations of these LRs per neuron-pair.
4/9 We then built an atlas predicting LR-mediated neuron-neuron interactions during cortical dev. It integrates the exp of ~8K LRs with downstream transcriptional networks across 729 neuronal pairs, prioritizing LR interactions based on known connectivity and neuronal maturation.
3/9 Using our extensive mammalian LR database (~8K pairs), we identified strong spatiotemporal correlations between ligands and receptors, suggesting their roles in neuronal interactions.
2/9 First, we tracked gene expression dynamics across 17 stages of mouse cortical development using our own and published data. This allowed us to generate “transcriptional landscapes,” capturing the spatiotemporal expression patterns of each major cortical neuron subtype.
1/9 The laminar organization and connectivity patterns among cortical neuronal subtypes exhibit remarkable specificity and stereotypy, but the molecular mechanisms orchestrating these phenomena remain enigmatic. We used sc and snRNA-seq to investigate these mechanisms in mice.
Delighted to showcase our atlas for the inference of ligand-receptor mediated interactions between neuronal subtypes during mouse cortex development. Herculean endeavor by former PhD student Rémi Mathieu (now @alleninstitute.bsky.social) and team, in collaboration with
@LudovicTelley
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