Using multimodal measurements, researchers present wearable sensors for monitoring drug pharmacokinetics in patients with #Parkinsons; Wearable sweat sensors for noninvasive monitoring of L-DOPA pharmacokinetics
www.nature.com/articles/s41...
New paper explores the North–South asymmetry of #Parkinsons mortality in Brazil between 2009 & 2023, speaking to "socio-economic vulnerabilities & disparities in access to specialized health services"
www.nature.com/articles/s41...
New paper reveals "a bacterial translocation axis from the gut to the brain" impacted by diet & genetics"; Mice on a high-fat diet had alterations in gut microbiome & gut permeability; Bacteria in the vagus nerve, but not other tissues
journals.plos.org/plosbiology/...
New review "examines evidence for cell-autonomous mechanisms linked to mitochondrial, lysosomal, or proteasomal perturbations & for non-cell-autonomous processes arising from glial & peripheral immune cells" in #Parkinsons
www.cell.com/trends/neurosciences/fulltext/S0166-2236(26)00027-5
Aspen receives adoption of Sasineprocel as the official nonproprietary naming of their investigational autologous cell therapy, ANPD001, being clinically tested for the treatment of #Parkinsons
aspenneuroscience.com/aspen-receiv...
New clinical trial registered: Integrative Research Laboratories AB has registered a Phase 1b, randomized, double-blind, placebo-controlled trial evaluating the safety & tolerability of multiple oral doses of IRL757 in 75 people with #Parkinsons & apathy
clinicaltrials.gov/study/NCT074...
New clinical trial registered: Researchers have initiated a Phase 2 study assessing target engagement for Terazosin in 120 people with #Parkinsons (the TZPD2 trial); Up to 1.5 years of treatment period
clinicaltrials.gov/study/NCT074...
Interesting: Early-life infection of human cytomegalovirus promoted dysfunctional & pathogenic microglia that drove adult-onset neurodegeneration in the eye & brain, without evident viral reactivation; PLX5622 treatment rescues cortical neuron density
www.science.org/doi/10.1126/...
New research highlights "a critical role of inherited DNA double-strand break repair deficiencies in #Parkinsons etiology & suggest potential avenues for personalized risk prediction & prevention"; n=123 PD patients of Taiwanese ancestry & 492 controls
www.nature.com/articles/s41...
Machine learning highlights 3 core genes (CBS, PRKAR2B, & RELA) in a bioinformatics analysis of ferroptosis & lipid metabolism in #Parkinsons; Investigators propose RELA(p65) as a promising diagnostic biomarker & therapeutic target for PD
link.springer.com/article/10.1...
Using behavioral screening & machine learning on 24 Drosophila models of familial forms of #Parkinsons, researchers identify clusters that converge on (1) mitochondrial function; (2) retromer/vesicle trafficking and proteostasis/autophagy.
www.nature.com/articles/s41...
New research provides a comprehensive behavioral & physiological assessments of non-motor & motor symptoms in mice injected with αSyn-PFFs in the duodenum at different time points
link.springer.com/article/10.1...
A 5-year longitudinal study of 345 PPMI participants highlights the heterogeneity in early #Parkinsons defined by clinical diagnostic criteria, underscoring the importance of shifting to biologically & functional impairment defined inclusion criteria
onlinelibrary.wiley.com/doi/10.1002/...
A multi-ancestral investigation of #Parkinsons was conducted to examine the impact of genome-wide homozygosity on disease risk & age at onset (AAO); Results highlight distinct patterns of runs of homozygosity enrichment associated with AAO
movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1...
Vima Therapeutics announces that the 1st Dystonia patient has been dosed in their Phase 2 study; Plus they announce extension of their Series A to $100 Million to help advance potential first-in-class oral therapy for dystonia & #Parkinsons
vimatx.com/2026/03/11/v...
Genetic analysis of a large-scale population-based Taiwanese cohort highlights both shared & ethnicity-specific #Parkinsons risk loci & identifies PRDM15 as a potential novel contributor to PD dementia
www.thelancet.com/journals/lan...
New "review explores non-profit funder approaches to reducing technical, policy, & cultural barriers to data interoperability across #Parkinsons & related disorders to improve research data findability, accessibility, interoperability, & reliability"
journals.sagepub.com/doi/full/10....
Using genotyping array data of 661 South African #Parkinsons cases & 737 controls, researchers conduct a polygenic risk score analysis; They highlight how ancestry composition & study design affect risk estimation in diverse populations
journals.plos.org/plosgenetics...
A new qualitative study explores cultural & systemic barriers in #Parkinsons diagnosis, treatment, & research participation among Asian Americans; “We have information about Parkinson's in Spanish...We don't have anything in Vietnamese.
journals.sagepub.com/doi/10.1177/...
Neuropath. & molecular analyses on 47 postmortem substantia nigra samples implicate ferroptosis (& to a lesser extent necroptosis) in #Parkinsons cell death; Researchers propose a “2-hit” model: early synucleinopathy amplified later by a neuromelanin-iron
onlinelibrary.wiley.com/doi/10.1002/...
Curious: Researchers report that a macrophage ferritin heavy chain—⍺-synuclein regulatory axis modulates ferroptosis during kidney injury; Monomeric SNCA exhibits ferrireductase activity, amplifying redox cycling and promoting ferroptotic cell death
insight.jci.org/articles/vie...
Researchers analysed stearoyl-coenzyme A desaturase & monounsaturated fatty acids-enriched lipids in the periphery of patients with #Parkinsons; They found elevated MUFA content in 4 lipid classes & higher SCD levels in PD
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Casma Therapeutics has announced that they have received additional funding support ($7.6M) from the Michael J Fox Foundation to support IND-enabling activities for their first-in-class TRPML1 agonist, CSM-101, targeting lysosomal dysfunction in #Parkinsons
www.casmatx.com/2026/03/10/c...
A new "Delphi consensus provides a set of expert-derived, clinically applicable recommendations to support proactive & individualised management of #Parkinsons"; Supports earlier initiation of adjunctive therapies, guided by the 4-1-0 criteria
journals.sagepub.com/doi/10.1177/...
Pioneering 1915 film from Spain on movement disorders. such as Parkinsonism, Huntington's disease, & Paradoxical Kinesia
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New viewpoint explores moving beyond the Homunculus with the new research on the “somato-cognitive action network” (SCAN) in #Parkinsons
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
New research finds no significant difference in lymphocyte count or neutrophil-to-lymphocyte ratio between patients with #Parkinsons (vs controls) in an ethnically diverse East London population
www.jns-journal.com/article/S002...
3. Peripheral biofluids clearly have great potential as disease markers, e.g. biomarkers of metabolism such as TAFA5 peripherally
2. Biomarkers of neuronal loss, such as neurofilament light, reliably distinguish the rapidly neurodegenerative synucleinopathy MSA from controls; however, with advancing disease severity, this relationship is not linear
Three key findings:
1. Levels of ‘multiple’ aggregating proteins differ between #Parkinsons disease & MSA from controls in peripheral biofluids. In particular, oligomeric alpha-synuclein can be directly detected & quantified using the NULISA panel
