Aaron Behr

Long-read metagenomics reveals phage dynamics in the human gut microbiome - Nature Complex prophage integration dynamics, including low-level induction, cross-family host range and transposase-mediated mobilization, challenge existing paradigms and deepen our understanding of phage–...

#NatMicroPicks

IScream phages in gut 🧬🦠

Long-read metagenomics reveals dynamic prophage integration, cross-family host jumps, and IS30-driven phage mobilization in the human gut

#MicroSky #MicrobiomeSky

www.nature.com/articles/s41...

Preprint out for myloasm, our new nanopore / HiFi metagenome assembler!

Nanopore's getting accurate, but

1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?

with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social

1 / N

Replicative selfish genetic elements are driving rapid pathogenic adaptation of Enterococcus faecium Understanding how healthcare-associated pathogens adapt in clinical environments can inform strategies to reduce their burden. Here, we investigate the hypothesis that insertion sequences (IS), prokar...

This is very exciting, especially the demonstrated potential to resolve such complex population heterogeneity!
In case of interest, we generated a bunch of metagenomic R10.4 data (longitudinal patient gut samples) here www.biorxiv.org/content/10.1... — would be interested to run myloasm on these