Philip Gunkel

Fantastic paper from the Kutay Lab. A must-read...

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...

☕ @kutaylab.bsky.social & co identify #lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether #heterochromatin to the envelope. Deletion of these proteins causes changes in 3D #genome organization, gene expression and cell fate determination.
bit.ly/4aPkNBc

RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes calle...

We are excited to share the revised version of our preprint elucidating the role of Annulate Lamellae in the assembly of Nuclear Pore Complexes #NPCs during early interphase.
Big thanks to Junyan Lin and all collaborators for their fantastic work! 🙏🎉

Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis DYT1 early-onset dystonia is a severe, incurable disorder of the central nervous system caused by mutations in the gene encoding Torsin1A (Tor1A, DYT1). Torsins are ER-resident AAA+-ATPases implicated...

We are very excited that our work on Torsins, dystonia and NE membrane fusion is out on bioRxiv: doi.org/10.1101/2025...

Fantastic collaboration with Madhav Jagannathan and the labs of Gautam Dey and Stefano Vanni!

Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation

Only a few days left to register...

Governed by surface amino acid composition: HIV capsid passage through the NPC barrier https://www.biorxiv.org/content/10.1101/2025.03.13.643050v1

I cannot currently access Pubmed (Germany) 🤷‍♂️

You can try out the european equivalent: europepmc.org

Registration is open for a great meeting in Potsdam, Germany (July 23-27) ... for everyone interested in the biology of the nuclear envelope and related topics (events.gwdg.de/event/1012/)

📣 Join us for #EESNucleus 🧬

Explore the dynamic world of the nucleus at the new EMBO | EMBL Symposium. From nuclear mechanics to pathomechanisms, join the conversation shaping modern cell biology.

🗓️ 18 – 21 November 2025
📥 Submit your abstract by 26 August

👉 https://s.embl.org/ees25-07-bl