Cynthia Turnbull

Tissue Regulatory T Cells FOXP3+ regulatory T cells (Tregs) have well-defined roles in limiting systemic immune responses against diverse stimuli. However, the observation that a subset of Tregs also enter nonlymphoid tissues,...

Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field

www.annualreviews.org/content/jour...

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity - Nature Immunology Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff?
Our latest paper with @gantierlab.bsky.social shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐
www.nature.com/articles/s41590-026-02429-2

Excellent read! #gammadeltaTcells

Beginning 2026 with a flipping good paper🚀 OSCA/TMEM63 proteins do double duty: they’re ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. 👏 @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...

γδ T cell-derived IL-4 initiates CD8+ T cell immunity - Nature Immunology The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.

γδ T cell-derived IL-4 initiates CD8+ T cell immunity

#gdTcells @natimmunol.nature.com

Dectin-2-dependent adaptive immunity governs intestinal clearance of systemic Candida albicans https://www.biorxiv.org/content/10.64898/2026.01.28.702262v1

7th of February 2024 vs last Wednesday 14th Jan, 2026. It took me nearly 2 years but gosh it’s good to be here! @lji.org

Reaching maturity: Thymic γδ T cell differentiation in mice and humans γδ T cell differentiation into specialized effector subsets during both early life and adulthood is reviewed.

Reaching maturity: Thymic γδ T cell differentiation in mice and humans

#gdTcells

Congratulations to all our #ASBMB2025 award winners! 🏆 Part of being a society is celebrating the success of our community, so cheers to all of you! 💯💯

Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial - Nature Medicine In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and...

Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor
nature.com/articles/s41...

TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function - Nature The transcription factors TCF1 and LEF1 promote self-renewal and regulatory functions in B-1a cells.

Nature research paper: TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function

go.nature.com/3JnVASZ

Thrilled to see James P Allison present at #IUIS2025. His work on CTLA-4 and immune checkpoint blockade fundamentally changed the way we treat cancer, putting immunotherapy on the map, which has saved so many lives. What a wonderful way to end this conference.

Excellent presentation by #IUIS2025 rising star Deborah Burnett @debburnett.bsky.social touching on the theory of clonal redemption in B cells.
Congrats Debbie! 🥳

TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function - Nature The transcription factors TCF1 and LEF1 promote self-renewal and regulatory functions in B-1a cells.

Phenomenal work by Sophie Shen @sophieshen.bsky.social and Carola Vinuesa @carovinuesa.bsky.social
on how TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function, presented by Carola at #IUIS2025. Read more in the paper released yesterday in Nature: www.nature.com/articles/s41...

Had a blast at the Immunology Run as part of #IUIS2025! What a fun way to raise funds for travel grants for young researchers. 🏃🏽‍♀️

Gabriel Victora @victora.bsky.social delighting everyone at #IUIS2025 with his elegant work on germinal centres, or “Darwinian evolution inside your armpit”. Check out his latest preprint replaying GC evolution on a quantified affinity landscape here: www.biorxiv.org/content/10.1...

Inference of germinal center evolutionary dynamics via simulation-based deep learning B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (GC) from which mature...

In a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers: arxiv.org/abs/2508.09871 🧵

Very excited participate in the 19th International Congress of Immunology, #IUIS2025 in Vienna. “Where immunologists meet” with over 3000 delegates from 104 countries and 320 oral presentations!

Explored the Kunsthistorisches Museum Wien, “Museum of Art History” in Vienna.
Many beautiful pieces by masters, ceiling art and marvellous architecture by Karl Hasenauer and Gottfried Semper.
The building itself is a work of art.

Honoured to receive the ACT/NSW 7News Young Achiever Award for Academic Achievement (also sponsored by Western Sydney University). It was a bit of a chaotic night flying back from Hawaii! A big thank you to my Dad for meeting me in Sydney and driving me back home!

Somatic mutation as an explanation for epigenetic aging - Nature Aging Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...

Somatic mutation as an explanation for epigenetic aging @natureaging.bsky.social
www.nature.com/articles/s43...