Joris Deelen

Epidemiological approaches to refine biomarkers of aging - Nature Aging Studies of biomarkers of aging encounter a range of epidemiological and methodological challenges, many of which are not fully acknowledged. In this Comment, we critically examine key challenges and s...

Epidemiological approaches to refine biomarkers of aging
www.nature.com/articles/s43...

Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk https://www.medrxiv.org/content/10.64898/2026.02.15.26346369v1

Personal-MetaboHealth thus offers a potential actionable health check in middle age for early prevention and extension of healthy lifespan.

@molepi.bsky.social @bds-lumc.bsky.social

In addition, we show that Personal-MetaboHealth can be improved by a 3-month combined lifestyle intervention in middle aged individuals (Growing Old Together study), specifically in those at risk with an unhealthy score at baseline.

Using data from the Leiden Longevity Study, we show that Personal-MetaboHealth retained predictive accuracy for all-cause mortality and showed an even stronger association with incident cardiometabolic disease in comparison to the original MetaboHealth score.

Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk The biomarker MetaboHealth represents a novel indicator of overall health in middle age and may potentially be suitable as actionable health check in prevention strategies. MetaboHealth is a blood-bas...

What started as a student project from Gabriela Natalle Lopes together with Niels vd Berg has now become a fleshed out preprint in which we present Personal-MetaboHealth, a personalised version of MetaboHealth based on clinically validated metabolic biomarkers.

🧪

www.medrxiv.org/content/10.6...

Rethinking the heritability of aging The genetic contribution to human longevity is greater than previously thought

Rethinking the heritability of aging
www.science.org/doi/10.1126/...

🆕 @science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families
www.biorxiv.org/content/10.6...

Met een kleine correctie; we leven op dit moment in Nederland gemiddeld 82 en geen 90 jaar.

"We leven langer, maar hoe kunnen we gezond langer leven?" Onderzoekers op zoek naar de sleutel | VRT NWS: nieuws Altijd op de hoogte van het laatste nieuws uit binnen- en buitenland dankzij de betrouwbare en diepgaande berichtgeving van VRT NWS.

Ben je geïnteresseerd naar ons onderzoek naar gezonde veroudering binnen de sectie @molepi.bsky.social van de afdeling @bds-lumc.bsky.social bij het LUMC? Kijk dan naar dit item van het Belgische programma @terzake.bsky.social van @vrtnws.be waarvoor ik geïnterviewd ben.

www.vrt.be/vrtnws/nl/ki...

Wat is de ideale methode als je wil beginnen met vasten? Zo pakken deze experts het aan. Voor meer tips, luister naar aflevering 3 van Leef als een Naakte Molrat:

Spotify: lnkd.in/eyGeyybx

Apple Podcasts: lnkd.in/e_JwiYvh

#fasting #vasten #gezondheid #afvallen #wetenschap

Was erg leuk om bij te dragen aan de @naaktemolratpod.bsky.social podcast serie over veroudering en vasten van Leon Doedens!

🚨 Deadline Extended!
🙏 RT: Postdoc opening @ Babraham Institute, Cambridge to study extracellular #proteostasis and #aging.
If you have #biochemistry expertise and want to join a world-class research environment, apply now!
✅ Global Talent Visa covered
📅 Apply by 09.01.26
👉 tinyurl.com/38rn6czz

Goede voornemens voor 2026? Luister vanaf 2 januari naar Leef als een Naakte Molrat voor de laatste lifestylehacks uit de wetenschap over voeding, vasten, sport en mentale gezondheid.

#podcast #lifehack #health #nutrition #fasting #fitness #mentalhealth

Interested in metabolomics/systems biology and aging in Drosophila? We have a post-doc opening! And of course, there will be plenty of opportunities for side projects on the @dogagingproject.bsky.social. 🐶
promislowlab.org/wp-content/u...

🔬#Postdoc position available: We are looking for new lab member to join our team working on Protein #Aggregation and #Ageing in Cambridge. Please spread the word. tinyurl.com/38rn6czz

This includes a variant in cGAS, for which we subsequently showed it leads to a reduced function of the protein in cell lines from both humans and mice, which nicely complements earlier work on this protein in animal models.

@molepi.bsky.social @marianbeekman.bsky.social @antebilab.bsky.social

🧬🧪

🚨Proud to present the latest preprint from our group, spearheaded by Pasquale Putter and the culmination of many years of work on the Leiden Longevity Study, in which we used multigenerational long-lived families to identify novel rare protein-altering genetic variants linked to ancestral longevity.

Low Genetic Risk for Coronary Artery Disease underlies Multigenerational Longevity and Healthy Aging Descendants of exceptionally long-lived families have a delayed onset of their first chronic disease. We therefore hypothesize that one of the key features explaining healthy survival up to high ages ...

🚀 preprint alert: medrxiv.org/cgi/content/...

🧬 How important is genetic predisposition to chronic diseases for healthy survival up to later age?

This includes a variant in cGAS, for which we subsequently showed it leads to a reduced function of the protein in cell lines from both humans and mice, which nicely complements earlier work on this protein in animal models.

@molepi.bsky.social @marianbeekman.bsky.social @antebilab.bsky.social

🧬🧪

🚨Proud to present the latest preprint from our group, spearheaded by Pasquale Putter and the culmination of many years of work on the Leiden Longevity Study, in which we used multigenerational long-lived families to identify novel rare protein-altering genetic variants linked to ancestral longevity.

Key takeaway: Absence of CAD disease risk alleles is one key-feature linked to longevity and alleles linked to cholesterol metabolism are a key component in healthy aging trajectories.
@jorisdeelen.bsky.social @marianbeekman.bsky.social

Congratulations Sophie and team!

Early‐Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies Isogenic Drosophila melanogaster vary greatly in longevity. Fractionation of an isogenic cohort based on climbing behavior early in life stratifies variation in the metabolome, longevity and mortalit...

I'm very happy to see this paper now out. We used early-life climbing ability to separate genetically identical short-lived and long-lived sub-cohorts of fruit flies, and to identify metabolites and metabolite modules that predict longevity.
onlinelibrary.wiley.com/doi/10.1111/...

My lab is associated with two fantastic project opportunities - one on circadian genes led by Matt Jones and one on inflammation in ageing led by Chris Mahony - which you can find in the 'Fundamentals of Life' theme at the link above.

Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026!

Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause?

Learn more about the team and our research here: www.dife.de/en/research/...

Please share! 🧠 🍔 💉

Open problems in ageing science: a roadmap for biogerontology - GeroScience The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...

I'm delighted to share our curated list of 100 open problems in ageing science.

This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience.

link.springer.com/article/10.1...

Dutch Society for Research on Ageing and BSRA sign collaboration agreement - BSRA Speaking at the launch of this collaboration between the British Society for Research on Ageing (BSRA) and the Dutch Society for Research on Ageing (DuSRA), leaders from both societies outlined their ...

📰Weekend read!

BSRA & Dutch Society for Research on Ageing sign collaboration agreement of
1. Mutural speaker exchange
2. Reciprocal meeting benefits
3. Joint policy work
4. Joint initiatives
5. Future plans, watch this space...

Read more - bsra.org.uk/dusra-collab...

Congratulations Sara!