@Bernard-S-Lopez.bsky.social

Congrats,
very important story

RAD51-mediated homologous recombination is a pro-tumour driver pathway - Oncogene Oncogene - RAD51-mediated homologous recombination is a pro-tumour driver pathway

Plot twist: homologous recombination actually promotes the development of cancer!

This discussion has been started in the hope that it will be useful, see the link:

doi.org/10.1038/s413...

A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner - Cell Death & Differentiation Cell Death & Differentiation - A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner

The LoL-DDR (doi.org/10.1038/s414...)
is dysregulated in transformed cell lines (doi.org/10.1038/s415...)

Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1 Abstract. Genetic instability is a major hazard threatening the fate of cells and ultimately of organisms. DNA double-strand break (DSB) is a highly toxic

The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability.
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...

What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...