Zachary Sanchez

Cytokines control the physical state of immune tissue Unlike most solid-like tissues, immune tissue is protean and reconfigurable—its component cells can patrol vast territories, find rare cellular partners, and dynamically self-organize into functional ...

1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1...

Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.

Exploring a New Frontier in Cell Communication: A Q&A with the Burnette Lab on Blebbisomes Since its February 2025 publication in Nature Cell Biology, a groundbreaking study from the Burnette Lab has drawn more than 44,000 Article Accesses—amplified by Vanderbilt’s new open access agreement...

A story about our blebbisome paper, "Exploring a New Frontier in Cell Communication: A Q&A with the Burnette Lab on Blebbisomes" has now been posted by @vubasicsciences.bsky.social!
medschool.vanderbilt.edu/basic-scienc...

It’s a little late, but as of last Monday, I am now officially Dr. Sanchez. So incredibly grateful for the training and mentorship that I received in the Burnette lab under @mag2art.bsky.social ! Can’t wait to change research paths a little bit and start studying Toxoplasma with the Lourido Lab!

Dr. Sanchez?

Yep!

Congratulations @ento-sanchez.bsky.social!
#CellBiology

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties - Nature Cell Biology Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.

Happy #FluorescenceFriday ! Today is an exciting day because I can finally share data from my thesis work. Below is a gif of a blebbisome, a new large extracellular vesicle that I describe and characterize in the article below. www.nature.com/articles/s41...

I’ll write more about this pre-print in the next few days, but please do take a look at this piece of work by Clément Dégut. It’s a 3D-printed open-source microscope that can image microtitre plates. Ideal for anyone looking for a new #DIY #science project

#OpenSource #3Dprinting #microscope

So happy to have had the opportunity to present my research at #ASCB this year. Can’t wait to soon share the published research with everyone! Be on the look out for a paper talking about blebbisomes!

Tau (gold) is shown in primary hippocampal neurons.

Tau is one of the most captivating cytoskeletal accessory proteins, shown here in hippocampal neurons for #FluorescenceFriday 🔬

Reactive oxygen species control protein degradation at the mitochondrial import gate This work identifies reactive oxygen species released by the electron transport chain as sentinel molecules that regulate localized protein degradation at mitochondrial TOM complexes, a mechanism that controls mitochondrial protein import and adjusts the abundance of the electron transport chain to cellular needs.

Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust electron transport chain abundance, with many implications for the role of ROS in development and disease.

www.cell.com/molecular-ce...

Vimentin DNA-PAINT 🌞 in COS-7 cells #FluorescenceFriday

Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein ...

Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses

www.nature.com/articles/s41...

Great thread full of #bioimageanalysis goodies

A cartoon bear dressed in a blue nightshirt and a red night hat, sitting asleep in a chair at the confocal microscope

Nothing like the confocal room to boost your melatonin levels and have you ITCHING for a nap at 3pm

Inaugural post 🦋 The apical microvilli of intestinal epithelial cells create dazzling displays as they assemble the #brushborder! This image was acquired on the remarkable #Nikon NSPARC in @tyskalabactual.bsky.social

I'm excited to rebuild this #science community over here on Bluesky! In honor of this clean slate, here's a repost of my favorite #epithelial cell building its brush border. @tyskalabactual.bsky.social

First #FluorescenceFriday here on 🦋 Hope you enjoy this cross-section of the intestinal epithelium, highlighting the actin within the #brushborder @tyskalabactual.bsky.social

Admittedly, this is a reversed movie of #microvilli collapsing, but how cool would it be if growth were synchronized like this? #FluorescenceFriday
@tyskalabactual.bsky.social

It's #FluorescenceFriday fresh off the press is this depth coded image of #Microtubules. @tyskalabactual.bsky.social

A cardiac myocyte (heart muscle cell) going through cell division surrounded by cardiac myocytes not going through cell division. DNA (yellow), myosin II (cyan) and actin filaments (magenta) are shown. #FluorescenceFriday #Science #Biology #CellBiology #microscopy

Hello BlueSky! Here's my inaugral post for #FluorescenceFriday: microtubules lead the way! #microtubules #microscopy #migration

Add me!

Happy #FluorescenceFriday! For my first one on this app, I’m showing a movie I got while taking the MBL physiology course. Using the NSPARC, I imaged Trichoplax stained with a membrane dye.