#Organoids #MucosalHealing #TissueRegeneration #RegenerativeMedicine #IBDResearch #DMMgrants
28.12.2025 21:20
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#Organoids #MucosalHealing #TissueRegeneration #RegenerativeMedicine #IBDResearch #DMMgrants
I am also deeply grateful to @dmmjournal.bsky.social from @biologists.bsky.social for awarding a Conference Travel Grant #DMMgrants, which has made it possible to attend and present at this exciting meeting. Looking forward to connecting with colleagues in Osaka!!!
I'm happy to share that I’ll be presenting our work on exploiting tissue regeneration for durable mucosal healing at the 12th Takeda Science Foundation Symposium on PharmaSciences – ORGANOID 4D: Development, Disease, Diversity and Discovery, taking place in Osaka, Japan on 23–24 January 2026 🇯🇵
🎧 Excited to share my Henry Stewart Talks (#HSTalks) interview on our recent @natureportfolio.nature.com paper — showing how liver X receptor (LXR) acts as a molecular “rheostat,” boosting intestinal repair while restraining tumor growth.
👉 Take a listen here: doi.org/10.69645/QUT...
Fantastic work, huge congratulations @katajistolab.bsky.social !!!
Thank you @ianlmorgan.bsky.social !!!
Finally thrilled to share this - my first real attempt at #SciComm! 🎉
Grateful to the amazing @investnscience.bsky.social team for organizing a fantastic workshop, providing the platform, editing support, and most importantly, encouraging critical thinking to simplify the message. Thank you!!!
Fascinating new @natureportfolio.bsky.social study from @thevinodlab.bsky.social @mskcancercenter.bsky.social:IL33, an alarmin from inflamed tissues, drives ILC2 migration from the gut to the pancreas, forming TLS with anti-tumor effects in PDAC. www.nature.com/articles/s41...
We just can't stop recruiting!
Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly
Come and be our colleague
Deadline 28 Feb, please spread the word
www.path.ox.ac.uk/vacancy/asso...
Big thanks to Amy E. Baek for spotlighting our recently published work in Nature @nature.com in the Editor's Choice section of @ScienceSignaling @science.org! www.science.org/doi/10.1126/...
Can I also join please!!!
Thanks Cancer Discovery Journal, @AACR for highlighting our recently published work @natureportfolio.bsky.social!!! The Liver X Receptor Axis Balances Intestinal Regeneration and Tumorigenesis doi.org/10.1158/2159....
Thanks Annika!!!
An epithelial adaptation mechanism to damage, whereby LXR functions as a rheostat, promoting tissue repair while limiting tumorigenesis @ejvillablanca.bsky.social @srudas.bsky.social
nature.com/articles/s41...
On a personal note - this work was a labor of love spanning over 7 years. I’m now on the #jobmarket, looking to start my own group and further explore how tissue homeostasis is maintained in the gut and beyond.
Would love to hear about any potential opportunity! #newbeginning
Grateful to our funders— @Cancerfonden @Åke Weibergs Stiftelse @FormasForsk @Vetenskapsradet @ERC_Research @Wstiftelserna @reNEW_Global
@EUbOPEN - for making this work possible!
Thank you @ barbmarte.bsky.social @ natureportfolio.bsky.social, and our fantastic reviewers who helped shape the paper into its final form.
A heartfelt thanks to @ ejvillablanca.bsky.social @ karolinskainst.bsky.social, for the trust, freedom to challenge the status quo, and unwavering support throughout this long journey! 🙌✨
A huge shoutout to all co-authors, especially@martinaparigi.bsky.social and@xinxinluo.bsky.social-two amazing colleagues and co-first authors I had the privilege to work with - and to all our collaborators. Special thanks to@katajistolab.bsky.social for teaching us the art of growing #organoids! 🙌✨
We uncovered a pathway that unlinks #regeneration and #tumorigenesis – a discovery with profound implications for #regenerativemedicine. This holds promise for #IBD, #cancer, and beyond!
Next, we explored how is LXR activated endogenously. Revisiting our #transcriptomics datasets from damage-repair models, we uncovered a key player: #CYP27A1, a cholesterol-metabolizing enzyme. It’s induced by damage and acts upstream of LXR – a critical piece of the puzzle!
How does LXR activation inhibit tumorigenesis?
Using longitudinal #bulk & #spatialtranscriptomics, we found LXR bolsters adaptive immunity - supporting B cells & CD8+ T cells to suppress tumor growth.
Interestingly, during tumorigenesis, LXR activation doesn’t induce AREG or similar EGFR ligands. Something to explore in the future! 🤔
How does LXR promote regeneration?🤔
Using #scRNAseq and #organoids, we found that LXR induces amphiregulin – an EGFR ligand – in epithelial cells (previously understudied cellular source), to promote regeneration, and was validated with AREG KO mice and neutralizing antibody.
Does it increase tumor risk? 🤔
Unlike other pro-regenerative modulators, LXR activation inhibited tumorigenesis – an #unlinker of #regeneration and #tumorigenesis!
Using #invivo gain and loss-of-function studies and #invitro #organoids, we showed that LXR activation in intestinal epithelial cells (IECs) promotes intestinal regeneration.
Previous studies have shown the anti-tumor potential of LXR: but could it hold the key to #unlinking #regeneration from #tumorigenesis? We wanted to find out.
We analyzed #transcriptomics datasets from two intestinal regeneration models #DSS and #irradiation and identified a key player: the #LXR pathway.
Activated in response to damage, it hinted at a potential role in promoting regeneration –a function that has not been explored before.
