And here’s an accompanying substack post providing an overview of the discussion:
www.psychiatrymargins.com/p/the-philos...
13.03.2026 13:56
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And here’s an accompanying substack post providing an overview of the discussion:
www.psychiatrymargins.com/p/the-philos...
Paper title: “Examining the Foundational Assumptions of the Hierarchical Taxonomy of Psychopathology” in Philosophy, Psychiatry, & Psychology
A new paper from the HiTOP Revisions Workgroup (and yours truly) on the conceptual and philosophical underpinnings of the framework. Recommended reading for anyone interested in questions of classification and psychopathology!
Here’s the journal article: muse.jhu.edu/pub/1/articl...
🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵
Link: www.biorxiv.org/content/10.6...
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Dominion
Wingspan
7 wonders
Carcassone
Ticket to Ride
Betrayal at house on the hill
Catan with seafarers expansion
Quacks of Quedlinburg
Azule
Kingdom Builder
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders
rdcu.be/ePmwD
From big to small: Emerging methods for enhancing precision psychiatry through transfer learning www.sciencedirect.com/science/arti...
I’m seriously intrigued by this. How are brains set up such that 4 lbs of wonderful in 2 hours doesn’t spiral into mania? That’s robust & highly nontrivial integration!
Overall social media use is declining.
Between 2020 and 2024, more Americans — especially the youngest (18–24) and oldest (65+) — report using no social media at all.
A small group of heavy users remains, but the middle is thinning out.
Looks like some clinically significant change for both. What are the odds midazolam somehow improved symptoms? I see that it is frequently used as a control, but briefly reducing anxiety/pain 2x a week for 8 weeks seems like more than placebo…
Interested in using the PCL-5 to measure PTSD symptoms in your EMA study?
We conducted item analysis to examine item thresholds & discrimination parameters & examined DIF across daily surveys
www.sciencedirect.com/science/arti...
@matthiasmichel.bsky.social and I are beavering away reading and responding to all the excellent commentaries on our BBS paper outlining an evolutionary account of visual consciousness.
In the meantime, if you missed our target article, it's available here:
www.cambridge.org/core/journal...
We're a month further into the job market - how are things looking? The good news is that the market does seem to have been delayed: ~150 new listings have appeared since my last post. The bad news is that the total is still substantially lower than what it was during the covid dip.
Intervening on a central node in a network likely does little given that its connected neighbors will "flip it back" immediately. Happy to see this position supported now.
"Change is most likely [..] if it spreads first among relatively poorly connected nodes."
www.nature.com/articles/s41...
Super proud of this collaboration with rockstar Ryan Raut - born out of playing in the sandbox in our last year of grad school! Multi-scale brain activity can be predicted from a simple measure of arousal like pupil diameter. Out with linear causality, in with dynamic systems to explain neurobiology
In this video, Andy Jahn discusses the latest developments in #SPM, the latest release #SPM25 and our recent #SPM Homecoming with the wonderful @corticalpete.bsky.social, @liviasimela.bsky.social and @johmedr.bsky.social.
youtu.be/VqzvUPV7pk8?...
Our new paper is out now in Neuron! 🎉 With @vaibhavtripathi.bsky.social @maxwellelliott.bsky.social Joanna Ladopoulou, Wendy Sun, Mark Eldaief, and Randy Buckner
Paper link: www.sciencedirect.com/science/arti...
Lab’s latest is out in Imaging Neuroscience, led by Kirsten Peterson: “Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding”, where we demonstrate a major improvement to standard fMRI functional connectivity (correlation) 1/n
8/ In contrast to standard power calculations, our results suggest that jointly optimizing sample size and scan time can boost prediction accuracy while cutting costs. For more complex study design, you can check out our calculator: thomasyeolab.github.io/OptimalScanT...
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
Dreaming of a dataset that tracks mood, sleep & activity to better understand affective instability (AI)…AND paired with advanced MRI? 🤯
Check out our new bioRxiv preprint for a 13–23 y/o community sample (n=10 and growing!) with multi-echo fMRI, EMA & actigraphy: www.biorxiv.org/content/10.1...
A putative neural correlate of mood!
One big (scandalous?) idea, simple analyses, and the STRONGEST brain/behavior correlation I've EVER seen (which is shocking, given that it's mood).
Work with: You-Ping Yang, @catrinahacker.bsky.social and Veit Stuphorn.
www.biorxiv.org/content/10.1...
A quick thought: My lab published 2 papers showing increased apathy in those with Parkinson’s on SSRIs, (and apathy is also associated with WM deficits). Probably unique neurotransmitter interactions in PD, but there are some hints at similar effects in other populations doi.org/10.1017/neu....
It's shocking how little is known about the brainstem red nucleus. In our new paper “The human brainstem’s red nucleus was upgraded to support goal-directed action” out now in @naturecomms.bsky.social we show that current thinking on the red nucleus is in need of a serious upgrade. rdcu.be/ehbOy
Comment: "Can a single brain cell be surprised?"
www.nature.com/articles/s41...
It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠
Thanks to everyone's feedback, we have updated our calculator to optimize sample size N & scan time T for fMRI studies: leonoqr.github.io/ORSP_Calcula...
The first new feature is that users can explore how different N & T leads to different accuracy, e.g., N=1000 & T=30min => 81% max accuracy. 🧵
