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Cassandra Hayne

@cassandrahayne

RNA Biochemist, leads the Hayne Lab at UChicago. https://haynelab.com/ R00 NIH/NIGMS MOSAIC scholar Views are my own (she/her)

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31.08.2023
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Latest posts by Cassandra Hayne @cassandrahayne

I was on Capitol Hill today with @asbmb.bsky.social urging lawmakers to support strong federal investment in
scientific research and training. Also to support : predictable and sustained funding.
#ASBMBAdvocates #ScienceServesUsAll

06.03.2026 21:54 πŸ‘ 9 πŸ” 5 πŸ’¬ 0 πŸ“Œ 1
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Folks from @rnasociety.bsky.social advocating for basic science research funding #ASBMBAdvocates @uwmadisonrna.bsky.social @cassandrahayne.bsky.social

06.03.2026 14:36 πŸ‘ 25 πŸ” 5 πŸ’¬ 0 πŸ“Œ 2
A line graph showing the number of NIH new and competitive renewal awards funded in fiscal year 2026 compared to fiscal years 2020-2025. The fiscal year 2026 curve lies below the other curves and appears to be flattening out somewhat. A total of 840 awards have been made in fiscal year 2026.

A line graph showing the number of NIH new and competitive renewal awards funded in fiscal year 2026 compared to fiscal years 2020-2025. The fiscal year 2026 curve lies below the other curves and appears to be flattening out somewhat. A total of 840 awards have been made in fiscal year 2026.

New and competitive renewal awards

Fewer than 40 new awards were made in the past week, compared to over 100 the previous week.

5/9

05.03.2026 16:38 πŸ‘ 17 πŸ” 13 πŸ’¬ 1 πŸ“Œ 5
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White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

This flattening may be due to the apportionment issue covered in the recent Nature story.

www.nature.com/articles/d41...

3/9

05.03.2026 16:38 πŸ‘ 15 πŸ” 7 πŸ’¬ 1 πŸ“Œ 1
A line graph showing the number of NIH projects funded in fiscal year 2026 compared to fiscal years 2020-2025. The fiscal year 2026 curve lies below the other curves and appears to be flattening out somewhat.

A line graph showing the number of NIH projects funded in fiscal year 2026 compared to fiscal years 2020-2025. The fiscal year 2026 curve lies below the other curves and appears to be flattening out somewhat.

All projects

The fiscal year 2026 appears to be flattening out a bit in the past week.

2/9

05.03.2026 16:38 πŸ‘ 8 πŸ” 4 πŸ’¬ 1 πŸ“Œ 2

New preprint alert! We share some of our recent insights about sequence similarity in IDP protein families and find that conservative substitutions in well-conserved binding motifs of the CITED proteins have big impacts on their ensembles and functions. Take a look!

www.biorxiv.org/content/10.6...

24.01.2026 14:02 πŸ‘ 10 πŸ” 7 πŸ’¬ 2 πŸ“Œ 1
The commitments in the SAFE Labs Handbook.

The commitments in the SAFE Labs Handbook.

A new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers.
buff.ly/K7CGFLV

28.12.2025 09:21 πŸ‘ 43 πŸ” 16 πŸ’¬ 1 πŸ“Œ 4
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NIH shut out hundreds of young scientists from funding to start their own labs Special Report: The NIH has shut out hundreds of young scientists from funding to start their own labs.

www.statnews.com/2025/12/08/t...

08.12.2025 13:26 πŸ‘ 38 πŸ” 26 πŸ’¬ 0 πŸ“Œ 2

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the β€šwoman in CryoEMβ€˜ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

18.11.2025 10:18 πŸ‘ 52 πŸ” 40 πŸ’¬ 0 πŸ“Œ 0
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Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404

04.10.2025 18:44 πŸ‘ 127 πŸ” 127 πŸ’¬ 4 πŸ“Œ 1

What are people using for calling m6A from pacbio revio data? This is for analysis of fiberseq library. Any suggestions appreciated, we are newbies with m6A analysis!

29.09.2025 02:31 πŸ‘ 5 πŸ” 10 πŸ’¬ 2 πŸ“Œ 0

This tracks.

06.09.2025 14:52 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I feel this way about cloning too. If you take the time to do the experiment correctly, you will usually succeed.

01.09.2025 23:02 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Listed are some of the many NIH research training programs that were terminated! Together, these programs supported thousands of trainees, whose careers are now in limbo. Such a great loss for discovery and innovation. We must protect our next generation of scientists!
#HandsOffNIH #ProtectScience

25.08.2025 21:58 πŸ‘ 53 πŸ” 29 πŸ’¬ 1 πŸ“Œ 0

It bears repeating that nearly the entire US enterprise in science and technology has been irreversibly gutted. This is shocking.

All this loss has occurred without any real benefit to the average US citizen. Except we now have the biggest, best funded secret police force perhaps ever.

Yay for us!

23.08.2025 16:25 πŸ‘ 331 πŸ” 118 πŸ’¬ 7 πŸ“Œ 7

Yes. There are a few gems that seem fairly consistent, like conicals, but most is much more.
I calculated that about 14% of our purchases are β€œluxury” consumables that we could acquire cheaper. Precast gels, commercial cloning (probably cheaper than in-house), premade buffers.

23.08.2025 17:04 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I’ve had a lab for less than 3yrs. In that time the costs of many science reagents have grown faster than inflation. I ordered an antibody today that I paid $383 for in 2023- today with a good promotion, I paid $467. Tariffs on top of that.
Other easy examples:
Grids are up about 30%
Gloves up 25%

23.08.2025 01:47 πŸ‘ 33 πŸ” 12 πŸ’¬ 1 πŸ“Œ 1

Congrats!

23.08.2025 01:21 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Jay Bhattacharya in a hot dog suit. We are all looking for the people who did this

Jay Bhattacharya in a hot dog suit. We are all looking for the people who did this

Hearing that all 27 NIH institutes have been instructed to stop using "paylines" in funding decisions starting Oct 1. Order issued in the last 48 hours.

Using paylines means scientific peer reviewers control funding decisions.
Removing them allows more political interference. πŸ§ͺ
1/

21.08.2025 23:00 πŸ‘ 106 πŸ” 57 πŸ’¬ 13 πŸ“Œ 6
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A joint statement with @savehealthresearch.bsky.social on the supreme courts decision today that will pave the way for hundreds of millions of dollars in NIH grant terminations. We are heartbroken and stand with the extramural community during this devastating time.

22.08.2025 04:10 πŸ‘ 14 πŸ” 7 πŸ’¬ 0 πŸ“Œ 0
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US Supreme Court lets Trump cut diversity-related NIH grants The U.S. Supreme Court let President Donald Trump's administration on Thursday proceed with sweeping cuts to National Institutes of Health grants for research related to racial minorities or LGBT people, part of his crackdown on diversity, equity and inclusion initiatives and transgender identity.

There is no solace for NIH funded researchers in this Supreme Court decision. Grants that were ripped away on dubious grounds, restored by a reasonable judge are now again terminated by an out-of-control Supreme Court. Labs will shutter, people will lose jobs. www.reuters.com/world/us/us-...

21.08.2025 21:12 πŸ‘ 514 πŸ” 276 πŸ’¬ 28 πŸ“Œ 13
Screenshot of Essay from Martin Schwartz on 'Why would anyone want to be a scientist'. An anniversary article from The Company of Biologists published in Journal of Cell Science.

The first few lines are: It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection. But, strange even to myself, I not only don't question the unfavorable risk-to-reward ratio but consider myself astonishingly lucky to be a scientist. There are three fundamental pleasures that have sustained me through 50 years of this madness.

Screenshot of Essay from Martin Schwartz on 'Why would anyone want to be a scientist'. An anniversary article from The Company of Biologists published in Journal of Cell Science. The first few lines are: It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently filled with failure and rejection. But, strange even to myself, I not only don't question the unfavorable risk-to-reward ratio but consider myself astonishingly lucky to be a scientist. There are three fundamental pleasures that have sustained me through 50 years of this madness.

Why would anyone want to be a scientist?

Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...

15.08.2025 13:19 πŸ‘ 81 πŸ” 46 πŸ’¬ 2 πŸ“Œ 8

Annnnd… hoping people actually read them.

10.08.2025 03:21 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I think a good rule of thumb is to spend at least as much time thinking about your data as you did obtaining it. It's common for people to spend a lot less time thinking than doing which gives rise to all kinds of problems.

08.08.2025 13:29 πŸ‘ 71 πŸ” 21 πŸ’¬ 2 πŸ“Œ 4
NOT-OD-25-142: Update: No-Cost Extension Functionality in eRA NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Update: No-Cost Extension Functionality in eRA NOT-OD-25-142. NIH

New Notice about No-Cost Extensions...

grants.nih.gov/grants/guide...

08.08.2025 16:33 πŸ‘ 25 πŸ” 15 πŸ’¬ 2 πŸ“Œ 1

There’s a nonzero chance you will die from a cancer that could have been curable because people who couldn’t pass 7th grade biology and are scared of things like β€œmRNA” and β€œriboflavin” and β€œwalkable cities” decided to make their ignorance everybody else’s problem

14.07.2025 23:08 πŸ‘ 8493 πŸ” 3503 πŸ’¬ 101 πŸ“Œ 96
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Grant terminations have grabbed the headlines and have seen legal action, but even more damaging to the US research enterprise has been the massive decrease in number of research grants issued by federal agencies

NIH has seen a decrease of 57% in the number of awards & 63% in value compared to FY24

14.07.2025 21:21 πŸ‘ 160 πŸ” 103 πŸ’¬ 3 πŸ“Œ 3
text in the link

text in the link

A big thanks to NC Sen. Thom Tillis for being the first signature on this bipartisan letter urging the Senate to maintain a strong commitment to funding for NIH in the Labor, Health and Human Services, and Education FY 2026 Appropriations bill. Is your Senator here?
www.aamc.org/research/adh...

25.06.2025 12:31 πŸ‘ 69 πŸ” 17 πŸ’¬ 4 πŸ“Œ 1
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U.S. Scientists Warn That Trump’s Cuts Will Set Off a Brain Drain

Please share widely with friends, family, and foes. You can read it for free without a subscription. www.nytimes.com/2025/06/03/u...

03.06.2025 14:35 πŸ‘ 54 πŸ” 32 πŸ’¬ 2 πŸ“Œ 2

*International students represent about 15% of all higher ed students.
*They subsidize US students, so expect domestic student costs to increase
*Trump complains about tariffs but he is destroying an industry where the US is a huge net exporter
www.nytimes.com/2025/05/23/u...

27.05.2025 20:30 πŸ‘ 1283 πŸ” 522 πŸ’¬ 56 πŸ“Œ 39