Razvan Borza

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.

Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

3D render of a Zincore complex locking ZFP91 onto DNA, promoting gene activation. Made in Blender with Molecular Nodes.

📢 Ready for this? A new way to think about Gene Regulation!

🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬

💪Proud to be part of this work led by @daaninthelab.bsky.social

Read more: science.org/doi/10.1126/science.adv2861

🚀 My first Cryo-EM structures are OUT on the PDB!

🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌

🔁Thank you for sharing!❤️

Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...

⬇️ 2nd video

⚠️Don't forget! You have FREE alternatives!

🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov

📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions.

Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

A metallic arm holding a protein, simulating a GPI-anchored protein attached to the surface of a membrane.

📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉

👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️

www.cell.com/trends/cell-...

GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells - Oncogenesis Oncogenesis - GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells

🚨 New strategy against colorectal cancer!

Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪

➡️Read more: www.nature.com/articles/s41...

Thank you! 😁

👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀

💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement.

❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁

Read it: www.jbc.org/article/S002...

Type VI inhibitor targeting both the catalytic site and the tunnel of Autotaxin (ATX). PDB ID: 9FXW

🚨New Article Out!!

📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒

🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance

♥️ Thanks for your support
Read more here: doi.org/10.1016/j.bm...

Congratulations! 💪

Thank you! 😁

Really crazy work!! wow.. Congratulation! 👏🏼

Congratulation on your work! 👏🏼

This is amazing!! wow! 👏🏼

Such a satisfying structure to look at! hahaha

Congratulation on you preprint! 👏🏼

This looks impressive!! 👏🏼

Nice poster! 👏🏼

I hope your presentation went well! 💪🏼

Cool image!! and Congratulations on your preprint! 👏🏼

That is a huge structure... Congratulations! 👏🏼

Amazing resolution for Cryo-EM!! 👏🏼

Congratulations! 👏🏼

Congratulations! 👏🏼

🚀 My first Cryo-EM structures are OUT on the PDB!

🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌

🔁Thank you for sharing!❤️

Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/...

⬇️ 2nd video

This sounds really really interesting. I might have a look at folddisco

I get you.... I really do hahahaha