π¨ πππ¬πππ«ππ‘ ππ’π π‘π₯π’π π‘π π¨
π‘epiGPTope: A Machine Learning-Based Epitope Generator and Classifier
π ACS Synthetic Biology
πhttps://doi.org/10.1021/acssynbio.5c00693
In a development that could transform how scientists study cancer, neurodegeneration and inflammation, #UCSB researchers have invented a modular, genetically encoded, protein-based sensor that enables MRI machines to visualize molecular activity inside cells.
Full story: https://ow.ly/cRmg50YqsiU
Oh no... π’ se va uno de los mejores blogs que recuerdo.
No sΓ³lo divulgaban sobre economΓa y polΓticas pΓΊblicas, tambiΓ©n representaban una forma de afrontar el debate racional, sosegada, humilde frente a la complejidad.
Una vΓctima mΓ‘s de la inmediatez y la polarizaciΓ³n de las redes sociales.
A detailed comparison of de novo designed proteins by NMR finally puts to rest the idea that structure prediction confidence metrics have any correlation with local flexibility
Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.
Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
βItβs a major advance, on the scale of an AlphaFold4. The problem, of course, is that we know nothing of the details.β
Isomorphic Labβs proprietary drug-discovery model is a major advance
go.nature.com/3Mm2ZnQ
#bioGUNE_News | π Yesterday we celebrated our 21st anniversary at #CICbioGUNE @brtaeus.bsky.social with a cutting-edge scientific day
πΈ Isabel FariΓ±as on neural stem cell quiescence
πΈ June EreΓ±o-Orbea on Siglecβsialoglycan cancer immunotherapy
π www.cicbiogune.es/news/cic-bio...
My reply to @anshulkundaje.bsky.social on the other site has been quoted in this @nature.com report on Isomorphic's new DDE model, which relies on private data to a degree that is probably unprecedented in the history of this field π§ͺπ§¬
Papers are like buses... You wait for ages, then two come along at once.
Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published!
www.nature.com/articles/s41...
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
Like, look at this wonderful hand drawn structures!
www.quantamagazine.org/how-colorful...
If you work with proteins, make sure to show your students Jane Richardsonβs early drawings and sketches of protein structures.
Not only because they are the foundation of virtually all protein representations today, but also because they are just beautiful!
Stories from #WomenInScience who changed how we visualize #proteins: Ahead of her 85th birthday, Jane Richardson (Duke Univ, @biophysicalsoc.bsky.social president 2012-13) discussed her life from making a telescope to developing ribbon diagrams for 3D protein structure www.nature.com/articles/s41...
Amazing!
As scientists, we always hope to do something meaningful that improves peopleβs lives. @kwplaxco.bsky.social is achieving just that.
Very exciting to see aptamer sensors moving one step closer to patients, and proud to have contributed my (little) grain of sand!
Wavelength AND lifetime multiplexed imaging, cool!
By @ciqus.bsky.social
onlinelibrary.wiley.com/doi/full/10....
This is how we first teach chirality to our undergrads !
Welcome to Bilbao!
#Ikerbasque
A few years ago, we developed biosensors for continuous, in vivo monitoring of drugsβincluding doxorubicin:
pubs.acs.org/doi/full/10....
This technology can help optimize dosing, tailoring chemotherapy treatments to each patient, at each moment.
Making personalized medicine a dream come true!
This study helps understanding why, and could potentially help fine tune doxorubicin dose, optimizing the risk-benefit balance to each patient's individual risk.
Great advance!
Doxorubicin is an important chemotherapy drug, but it has important cumulative cardiac toxicity.
This limits its use in cancer, specially in relapsing patients, who already received the maximum allowed dose during their first treatment.
Very interesting study on the cardiac toxicity of doxorubicin chemotherapy.
By researchers from CNIC, Spain:
academic.oup.com/eurheartj/ad...
I knew it!
New preprintπ¨
Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Γ
RMSD to the input. Perfect design?
What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be?
Why to be waryπ§΅π
We are proud to introduce the Program Planning Committee for the 40th Anniversary Symposium of The Protein Society!
This outstanding team will curate an unforgettable scientific program for our 2026 meeting.
Stay tuned for more info!
#PS40 #TheProteinSociety #ProteinScience #TPS2026
They are going down the folding funnel
πππ
βThere were some cells in there that were very messed upβ
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
#bioGUNE_Outreach | π¨ La ciencia y el arte vuelven a encontrarse en #CICbioGUNE @brtaeus.bsky.social
Recibimos al alumnado de #ArgiArte en una nueva ediciΓ³n de #CICbioArte para explorar el metabolismo a travΓ©s del #Pointillismo
π Eskerrik asko!
π www.cicbiogune.es/news/cic-bio...
