Excited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6...
1/3
Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.01.30.702923v1
The Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...
Together these data show that CP-AMPARs in the nucleus accumbens control the progression from social interaction to pair bonding via neuronal and ensemble level encoding
CP-AMPARs mediate excitation of fast-spiking interneurons (FSIs) and with electrophysiology we found FSIs coordinate medium spiny neuron ensemble activity.
Pharmacological blockade of CP-AMPARs blocked pair bond formation. With in vivo calcium imaging, we show that blockade of CP-AMPARs paradoxically disrupts partner neuronal ensemble formation and encoding while increasing the proportion of partner-selective neurons.
New paper from @neurozoe.bsky.social www.nature.com/articles/s41.... We uncover a role for nucleus accumbens calcium permeable AMPA receptors (CP-AMPARs) in pair bond formation. Congrats to first author Mostafa and all the other amazing co-authors!
Thrilled this is out, led by former PD Cameron Ogg (now with her own lab at @rhodescollege.bsky.social!). It was a driven by a desire to see, in real-time, how LC activity/NE release influences downstream targets in behaving animals. SO hard to do, but Cameron did it! www.cell.com/cell-reports...
Happy to discuss whenever you do!
Together these results suggest LC lesions worsen pre-existing pathology and behavioral dysfunction, rather than accelerate their onset.
Congrats to all co-authors!
Interestingly we found that AD genotype and DSP-4 rarely interacted to affect phenotypes. Instead each factor led to distinct phenotypes like apathy and changes in arousal (DSP-4) or social recognition deficits and anxiety (TgF344-AD).
New pre-print led by the talented undergrad Alexia with @davidweinshenker.bsky.social
We used chronic DSP-4 treatment to lesion the LC-NE system in young TgF344-AD rats to see whether early degeneration led to accelerated onset of pathology and behavioral deficits.
www.biorxiv.org/content/10.1...
At #SFN2025 and interersted in the 🔵? Check out posters from Leslie Hassanein (D52; neuromelanin in the mouse locus coeruleus) and Maggie Tish (C59; human 3D locus coeruleus organoids) today from 1:00-5:00!
With 2 postdocs moving on to faculty positions🥳, we're looking to hire someone new. If you're interested in norepinephrine and neural circuits, please apply! tinyurl.com/42bfe24k
Abstract deadline extended for the Integrative Neuromodulatory Subcortical Systems 2025 meeting! Supported by @ISTAART and hosted by @NSS_PIA & @SleepPIA 🧠💤
Boston, MA USA or online | July 17-18
📅 Abstracts due 4/15 11:30pm EST
✅ Registration & more info: education.martinos.org/inss2025/
Check out the amazing line up of speakers for the Catecholamines GRC! Apply for GRC www.grc.org/catecholamin... & GRS www.grc.org/catecholamin.... In these uncertain times we appreciate any donation to support the participants in the GRC my.grc.org/p/contributi... & GRS my.grc.org/p/contributi...
For anyone studying catecholamines please consider applying for the GRC and GRS (trainees only!) Catecholamines being held in August of this year. I'll be coordinating the GRS portion of the meeting with Darshana, so please reach out with any questions.
We're also looking for funding to support the registration and travel for our attendees, so if you're interested in supporting or know someone who might, please get in touch!
For LC researchers on BlueSpot Slack but haven't checked it, @mikekelberman.bsky.social and Ellen Rodberg will present their work on LC ephys tomorrow at 11 am EST. Link on General channel. If you are not on BlueSpot and want to attend, email me dweinsh@emory.edu.
www.biorxiv.org/content/10.1...
Introducing myself on here! I'm a Post-Doc in Zoe Donaldson's lab at CU Boulder interested in using prairie voles to understand social deficits in Alzheimer's disease, with a side interest in the coolest brain region, the locus coeruleus 🔵. Check out two of my most recent publications below:
You can add me to the list! Current Post-Doc with Zoe Donaldson (I'll see what I can do to get her to move over)
