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Nsignificannot

@nsignificannot

Silverback Gorilla. 🦍 Yellow Dog Dem. Married 50+ years and she is my sweetheart. Believe in God, Truth, Love, Justice.

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Latest posts by Nsignificannot @nsignificannot

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10.03.2026 11:39 πŸ‘ 33 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0

Think of Donald as a giant heap of fresh orange shit. Now think of Putin as the cock that climbs atop it to crow.

10.03.2026 02:48 πŸ‘ 4 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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10.03.2026 02:48 πŸ‘ 13 πŸ” 7 πŸ’¬ 3 πŸ“Œ 0
Preview
The Pete Hegseth Exception Nearly a year after a national-security scandal erupted on my iPhone, no one in the Trump administration has faced consequences.

www.theatlantic.com/magazine/202...

10.03.2026 02:48 πŸ‘ 5 πŸ” 4 πŸ’¬ 2 πŸ“Œ 0
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Mamdani stands by β€˜sacred’ First Amendment amid bigotry and violence New York City Mayor Zohran Mamdani addressed Monday the violence that broke out over the weekend between Islamophobic protesters and counterprotesters outside his official residence.οΏ½ β€œAnti-...

www.dailykos.com/stories/2026...

10.03.2026 02:48 πŸ‘ 10 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Alexander brothers found guilty on all counts in sex trafficking trial Alon, Oren and Tal Alexander have been on trial in New York City.

www.aol.com/articles/ale...

10.03.2026 02:48 πŸ‘ 7 πŸ” 3 πŸ’¬ 2 πŸ“Œ 1

πŸ‘‡

10.03.2026 02:48 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
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RELEASE THE FILES

10.03.2026 02:48 πŸ‘ 27 πŸ” 16 πŸ’¬ 1 πŸ“Œ 0

Sht must stop. We're the ones to do it!
youtu.be/_r9xXLEilF0?...

10.03.2026 18:59 πŸ‘ 5 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0

Of course he profited and yes, you will exploit that.

10.03.2026 19:11 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1
10.03.2026 19:00 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

What facts?
Those he knew about.
How did he know about the alleged facts?
The facts are facts, not just alleged.
But what are they?
The facts the president knew about.
Knew about how?
Sources.
What sources?
The sources with the facts.
What facts?
Those he knew about.

10.03.2026 19:07 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1

Just πŸ”₯πŸ”₯πŸ”₯ from @davidjbier.bsky.social - incredible work by the principled libertarians at @cato.org

10.03.2026 19:00 πŸ‘ 75 πŸ” 12 πŸ’¬ 2 πŸ“Œ 1
Preview
White House Says About 150 U.S. Troops Have Been Injured In Iran War President Donald Trump has repeatedly said to expect more casualties.

President Donald Trump has repeatedly said to expect more casualties.

10.03.2026 19:00 πŸ‘ 12 πŸ” 11 πŸ’¬ 5 πŸ“Œ 0
Preview
Trump sweats that he's let 'little devil' Lindsey Graham demolish his legacy: analysis President Donald Trump is sweating that his war in Iran will blot his legacy with an indelible black stain β€” and he's blaming a key ally for making it happen, a columnist wrote Tuesday.While the 47th President of the United States has much to worry about when it comes to his legacy β€” from his promin...

President Donald Trump is sweating that his war in Iran will blot his legacy with an indelible black stain β€” and he's blaming a key ally for making it happen, a columnist wrote Tuesday.

10.03.2026 19:00 πŸ‘ 23 πŸ” 12 πŸ’¬ 14 πŸ“Œ 2

In another 90 days they will be wearing Trump brand approved tidy whiteys.

10.03.2026 19:01 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Amazing extra galactic giant.

10.03.2026 18:57 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Located in the Large Magellanic Cloud, at a staggering distance of over 160 000 light-years from us, WOH G64 is a dying star roughly 2000 times the size of the Sun. This image of the star (left) is the first close-up picture of a star outside our galaxy. This breakthrough was possible thanks to the European Southern Observatory’s Very Large Telescope Interferometer (ESO’s VLTI), located in Chile. 

The new image, taken with the VLTI’s  GRAVITY instrument, shows that the star is enveloped in a large egg-shaped dust cocoon. The image on the right shows an artist’s impression reconstructing the geometry of the structures around the star, including the bright oval envelope and a fainter dusty torus. Confirming the presence and shape of this torus will require additional observations.

Credit: ESO/K. Ohnaka et al., L. CalΓ§ada

Located in the Large Magellanic Cloud, at a staggering distance of over 160 000 light-years from us, WOH G64 is a dying star roughly 2000 times the size of the Sun. This image of the star (left) is the first close-up picture of a star outside our galaxy. This breakthrough was possible thanks to the European Southern Observatory’s Very Large Telescope Interferometer (ESO’s VLTI), located in Chile. The new image, taken with the VLTI’s GRAVITY instrument, shows that the star is enveloped in a large egg-shaped dust cocoon. The image on the right shows an artist’s impression reconstructing the geometry of the structures around the star, including the bright oval envelope and a fainter dusty torus. Confirming the presence and shape of this torus will require additional observations. Credit: ESO/K. Ohnaka et al., L. CalΓ§ada

WOH G64 is an enormous star, 2000 times the diameter of the Sun. If you put it in the Solar System, it would extend out to the orbit of Saturn!

It's so big that we can take a direct picture of it, even though it lies outside our own galaxy. πŸ§ͺπŸ”­

www.eso.org/public/news/...

10.03.2026 13:11 πŸ‘ 25 πŸ” 2 πŸ’¬ 1 πŸ“Œ 1
Preview
Wide-swath altimetry maps bank shapes and storage changes in global rivers - Nature Observations of river channel geometry and monthly water storage changes for 126,674 river reaches worldwide are derived from the first water year of the Surface Water and Ocean Topography satelliteΒ mission.

A near‑global map of river channel shape and monthly water‑storage change, based on satellite observations of almost 130,000 river sections worldwide, is reported in Nature. πŸ§ͺ

10.03.2026 13:24 πŸ‘ 11 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Get outside!
The farther and longer the better.

10.03.2026 18:50 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
A Neurobiological Proposal of nature’s restorative effects. Exposure to natural environments engages a multilevel restorative cascade linking perceptual, autonomic, cognitive, and affective systems.

A Neurobiological Proposal of nature’s restorative effects. Exposure to natural environments engages a multilevel restorative cascade linking perceptual, autonomic, cognitive, and affective systems.

Nature Exposure Triggers Brain Reset

Nature exposure modulates default mode, salience, and attentional brain networks.

Our brain on nature:
A scoping review of the neuroscience of nature exposure πŸ§ͺ
www.sciencedirect.com/science/arti...

10.03.2026 13:32 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 2
Plasma extracellular vesicles (EVs) increase during acute myocardial infarction (MI), correlate with myocardial injury, and mobilize immune cells from the spleen to the circulation. These cells are transcriptionally activated even before tissue recruitment, yet the mechanisms driving this priming are unclear. We show that plasma EVs isolated at hospital presentation with MI are enriched in miRNA-320b. Endothelial cells upregulate miRNA-320b in EVs following inflammatory stimulation. Target gene pathway analysis revealed enrichment in adhesion and cytokine signaling. Endothelial EVs promoted monocyte adhesion and induced IL6 and TNF mRNA expression in macrophages while dampening cytokine secretion. RNA-sequencing of MI patient neutrophils and monocytes confirmed significant enrichment of miRNA-320b targets. Peripheral blood mononuclear cells treated with MI plasma EVs showed similar gene regulation. These findings suggest that EV-mediated transfer of miRNA-320b primes immune cells for adhesion and cytokine signaling. Understanding this signaling axis may enable therapeutic immunomodulation of immune cells to improve repair following MI.

Plasma extracellular vesicles (EVs) increase during acute myocardial infarction (MI), correlate with myocardial injury, and mobilize immune cells from the spleen to the circulation. These cells are transcriptionally activated even before tissue recruitment, yet the mechanisms driving this priming are unclear. We show that plasma EVs isolated at hospital presentation with MI are enriched in miRNA-320b. Endothelial cells upregulate miRNA-320b in EVs following inflammatory stimulation. Target gene pathway analysis revealed enrichment in adhesion and cytokine signaling. Endothelial EVs promoted monocyte adhesion and induced IL6 and TNF mRNA expression in macrophages while dampening cytokine secretion. RNA-sequencing of MI patient neutrophils and monocytes confirmed significant enrichment of miRNA-320b targets. Peripheral blood mononuclear cells treated with MI plasma EVs showed similar gene regulation. These findings suggest that EV-mediated transfer of miRNA-320b primes immune cells for adhesion and cytokine signaling. Understanding this signaling axis may enable therapeutic immunomodulation of immune cells to improve repair following MI.

New paper with the Akbar Lab @ox.ac.uk: After a heart attack, microRNA-filled vesicles activate immune cells. This triggers inflammation, worsening tissue damage. Targeting these signals may limit injury and improve repair. doi.org/10.1016/j.is... πŸ§ͺπŸ«€πŸ§¬πŸ–₯️ #cardiosky #immunosky @cp-iscience.bsky.social

10.03.2026 14:02 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Into a black hole.

10.03.2026 18:47 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
HOW MUCH MADNESS WILL
WE BE FORCED TO ENDURE? 
HOW MUCH TRAUMA?
HOW MUCH MISERY?
HOW MUCH CHAOS?
HOW MANY LIVES RUINED?
HOW MANY LIVES LOST?
HOW FAR WILL THIS IDIOTIC 
MADMAN BE ALLOWED
TO DRAG US ALL DOWN?

HOW MUCH MADNESS WILL WE BE FORCED TO ENDURE? HOW MUCH TRAUMA? HOW MUCH MISERY? HOW MUCH CHAOS? HOW MANY LIVES RUINED? HOW MANY LIVES LOST? HOW FAR WILL THIS IDIOTIC MADMAN BE ALLOWED TO DRAG US ALL DOWN?

10.03.2026 16:23 πŸ‘ 6 πŸ” 4 πŸ’¬ 3 πŸ“Œ 1

That's right, the rich are doing just fine. One of them told me he would vote for Trump again a thousand times. As far as rich people are concerned, the rest of us can just die. And quickly, please, so as not to cost THEM anything.

10.03.2026 14:41 πŸ‘ 11 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0

You’d think, but I know a (retired) professor who is maga. Special education/psychology. The oldness and the whiteness can’t be shaken off!

10.03.2026 15:26 πŸ‘ 6 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Can't get dumber than a non-gazillionaire Republican voter.

10.03.2026 14:19 πŸ‘ 17 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0

But we got eggs.

10.03.2026 14:20 πŸ‘ 11 πŸ” 2 πŸ’¬ 2 πŸ“Œ 0

This nation has its head up its ass, and apparently no one thought to bring a flashlight.

10.03.2026 14:16 πŸ‘ 29 πŸ” 4 πŸ’¬ 2 πŸ“Œ 0

You’ll do much better than that.

On average, his golfing escapades cost the taxpayer around $3.5-4 million dollars.

10.03.2026 14:58 πŸ‘ 54 πŸ” 10 πŸ’¬ 5 πŸ“Œ 1