Lyn Jones

Excited to present our work on molecular glue degraders at the SMR Target to Patient conference in the Wellcome Genome Campus next month - looks like a very strong line-up. www.smr.org.uk/Meetings/202... #TargetedProteinDegradation #InducedProximity #MolecularGlues #DrugDiscovery #ChemicalBiology

I am walking for Dana-Farber patients Together against cancer at the Jimmy Fund Walk

I’m taking steps to defy cancer at the Jimmy Fund Walk. Every donation to my walk will make an impact on the lives of patients and families at Dana-Farber. #JimmyFundWalk danafarber.jimmyfund.org/site/TR?fr_i...

Promotional graphic for the 2026 RSC Medicinal Chemistry Emerging Investigator Lectureship nominations.

We’re excited to announce that nominations for our 2026 Emerging Investigator Lectureship are now open📢

Details about how to nominate: www.rsc.org/standards-an...

We’re looking for up-and-coming researchers in drug discovery within 12 yrs of their PhD.

Nominate before 31 October 2025!
#chemsky 🧪

The Linnean Medal for Advocacy An awarded to scientists for an outstanding contribution to the natural sciences.

Who do you think has made an impact as a lifetime ambassador for nature? Nominate them for the Linnean Medal for Advocacy.

The award recognises an exceptional track record in raising public awareness and advocating for the protection of nature.

Submit a nomination by 30 September.

Niclosamide: CRL4AMBRA1 mediated degradation of cyclin D1 following mitochondrial membrane depolarization Targeted protein degradation has emerged as a promising approach in drug discovery, utilizing small molecules like molecular glue degraders to harness the ubiquitin-proteasome pathway for selective…

🔓Check out this #OpenAccess article by @labthoma.bsky.social and colleagues where they investigated the potential of niclosamide as a molecular glue degrader targeting the proto-oncogene cyclin D1👀🔥

pubs.rsc.org/en/content/a...

📍EPFL, @fmiscience.bsky.social 🧪

Fellowships Job: Postdoctoral Research Fellow - Jones Lab Chemistry at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA Postdoctoral Research Fellow - Jones Lab Chemistry job

We're hiring postdoctorate fellows in covalent chemical biology - pass the word. careers.dana-farber.org/job/11940/po...
careers.dana-farber.org/job/11941/po...

RSC Medicinal Chemistry promotional graphic for the Induced-Proximity Pharmacology collection, with QR code.

📢We are delighted to share our latest themed collection on Induced-Proximity Pharmacology, guest edited by @lynjoneschembio.bsky.social, @hartungingo.bsky.social & Lindsey James!

Explore the articles that make up this fantastic collection, here👇
pubs.rsc.org/en/journals/...

#chemsky 🧪

Promotional graphic for the RSC Medicinal Chemistry Editor's Choice collection with QR code.

Next up in the RSC Medicinal Chemistry Editor's Choice collection are Sankar Guchhait's chosen articles!

Be sure to read our blog to see what he chose and why 👉 blogs.rsc.org/md/2025/06/1...

And scan the QR code to see our collection as it grows👀

Photoaffinity enabled transcriptome-wide identification of splice modulating small molecule–RNA binding events in native cells Splice modulating small molecules have been developed to promote the U1 snRNP to engage with pre-mRNAs with strong and altered sequence preference. Transcriptomic profiling of bulk RNA from compound treated cells enables detection of RNAs impacted; however, it is difficult to delineate whether transcriptional chang

Splice modulators, meet your match. 🔦 Using photoaffinity labeling + Chem-CLIP, researchers mapped small molecule–RNA binding across the transcriptome and found... telomerase?!
Wild.

Read the study: doi.org/10.1039/D4CB...

RSC Medicinal Chemistry 2024 Emerging Investigators collection promotional graphic.

We are delighted to announce that our 2024 Emerging Investigators collection is now online👀

This themed collection aims to highlight the achievements of some early career researchers in the medicinal chemistry community.

Access it here👉 pubs.rsc.org/en/journals/...

#Chemsky🧪

One verse of a poem from the Botanic Garden, Part 2, Containing the Loves of the Plants. A Poem. By Erasmus Darwin, 1789. There is a small drawing of a vegetable lamb beside the text. "E'en round the pole the flames of Love aspire, And icy bosoms feel the secret fire!— Cradled in snow and fann'd by arctic air Shines, gentle BAROMETZ! thy golden hair; Rooted in earth each cloven hoof descends, And round and round her flexile neck she bends; Crops the grey coral moss, and hoary thyme, Or laps with rosy tongue the melting rime; Eyes with mute tenderness her distant dam, Or seems to bleat, a Vegetable Lamb."

Darwin's grandfather was known for writing somewhat scandalous, Linnaeus-inspired poetry about the reproductive habits of plants. This #WorldPoetryDay we present you with this excerpt about the mythical #VegetableLamb without further comment.

📣 Last chance to register! The 2nd SMR Molecular Glues Meeting - 21st March 2025 🚀🚀🚀

🌟 World-class Speakers
🌟 Cutting-edge Insights
🌟 Networking Opportunities

📅 Date: 21st March 2025
📍 Location: GSK Stevenage, UK
🔗 Register here: www.smr.org.uk/Meetings/202...

kermit the frog from the muppet show is standing in front of a red curtain ALT: kermit the frog from the muppet show is standing in front of a red curtain

Still hopping for more frog content? A paper published in the Zoological Journal of the Linnean Society highlights a new(ish) species of proto-amphibian named after the universally beloved celebrity, #Kermit the Frog. @zoojlinnsoc.bsky.social

academic.oup.com/zoolinnean/a...

RSC Medicinal Chemistry promotional graphic for the 2025 Emerging Investigator Lectureship winner - Michael Bollong.

📢We are delighted to announce that Michael Bollong (@scripps.edu) has been awarded the 2025 RSC Medicinal Chemistry Emerging Investigator Lectureship🎉

Join us in congratulating Michael and read our blog to find out more about him and his work: blogs.rsc.org/md/2025/01/3...

#Chemsky 🧪

RSC Medicinal Chemistry outside front cover for vol 16, issue 3.

RSC Medicinal Chemistry inside front cover for vol 16, issue 3.

Issue 3 is now online and ready to read👇

pubs.rsc.org/en/journals/journalissues/md#!issueid=md016003&type=current&issnonline=2632-8682

#Chemsky

How short can you make a PROTAC linker? We designed the first degrader of an ER-resident protein (IRE1a) that has physicochemistry more like a molecular glue than a traditional PROTAC pubs.rsc.org/en/content/a... #PROTAC #TPD @rscmedchem.rsc.org