@razanilab
The Razani lab (www.razani.org) @ Center for Immunometabolism (cim.pitt.edu) and Vascular Medicine Institute (vmi.pitt.edu), University of Pittsburgh studies macrophages, autophagy-lysosomes, & nutrient sensing/signaling in metabolic disease
New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their ATVB review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪
www.ahajournals.org/doi/10.1161/...
Happy to announce new work by Postdoc Fellow Yu-Sheng Yeh & @razanilab.bsky.social showing natural sugar #trehalose (known #autophagy #TFEB inducer) improves #obesity #metabolism. Caveat: it is ineffective by oral route & KO of gut enzyme #trehalase doesn't help.
www.frontiersin.org/journals/nut...
Great showing by @razanilab.bsky.social at #VascularDiscovery25 in Baltimore the past 3 days. Kudos to efforts of Dr. Kathleen Martin, the entire organizing committee, & @americanheart.bsky.social for the excellent programming & opportunity to present our work. See you all next year in Bellevue, WA!
Spilling the skinny on fat cells!
@razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/UPFJ5sO
Spilling the skinny on fat cells!
ASCI member @razanilab.bsky.social & team discover the process for adaptation to fasting and cold-induced lipolysis involves lysosomal lipolysis: buff.ly/Wc9YdnR
Nice work in @cp-immunity.bsky.social by Cobo & Glass labs showing #macrophage crystalline/particle uptake universally induce #lysosome #transcription program via #AMPK #TFEB independent of #inflammation pathways. Thx for including @razanilab.bsky.social in the journey.
www.cell.com/immunity/abs...
We thank all our @razanilab.bsky.social members and many collaborators in making this happen 🤝
Lysosomal Acid #Lipase (Lipa/LAL) is upregulated in #AdiposeTissue during #fasting, cold exposure, and even #obesity. When we ablate #adipocyte Lipa/LAL, mice cannot undergo full #lipolysis with difficulty maintaining body temperature in cold. On #highfat diet, they become obese.
Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL)
jci.org/articles/view/185340
Announcing #Pittsburgh Metabolism Consortium. Joint venture by the Endocrinology Division, Center for Immunometabolism (CIM), Center for Mitochondrial Medicine (C3M), we aim to bring together the #metabolism community at the University of Pittsburgh. Spring seminar series start next week 🤩
Fresh off the press data (for FY24) on the immense economic impact of #NIH #biomedical #science research. $2.56 goes into economy for every $1 grant funding. 💪
www.unitedformedicalresearch.org/annual-econo...
Excellent #immunometabolism concept presented by Garaude lab @univbordeaux.bsky.social in @nature.com. #macrophage #nutrient use of dead bacteria via #phagocysosis drives distinct #metabolism pathways. #mTOR rears its head of course. #efferocytosis should be up next!
www.nature.com/articles/s41...
Is dietary #protein and #mTOR good for skeletal muscle health or not? At least for #sarcopenia in elderly it is paradoxically harmful and enhancing #BCAA catabolism is protective. Interesting work in @natureaging.bsky.social by lab of Prof. Tao Li @ Sichuan University.
www.nature.com/articles/s43...
Hello everyone, greetings from members of the Razani laboratory. First post for us here. We heard many #physicians, #scientists, and #entrepreneurs also started a presence here and so we wanted to join the fun and learn from you all!