First-in-human drug trial lowers high blood fats In a Phase 1 clinical study, researchers led by EPFL and their partners report that a new liver- and gut-targeted oral drug can safely lower triglycerides and other blood lipids.

Our new study is out in Nature Medicine! Using human genetic data supports targeting LXR to treat lipid disorders! Thanks to our collaborators, @OrsoBio and @Takanori Takebe. Congrats to Xiaoxu and all colleagues.

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Happy to share the positive Phase 1b/2a Clinical Data for Oral Mitochondrial Protonophore TLC-6740 developed by OrsoBio in Combination with Tirzepatide! Looking forward to hearing more achievements from our collaborators in 2026. www.businesswire.com/news/home/20...

A consensus guide to preclinical indirect calorimetry experiments - Nature Metabolism The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

The new standards for indirect calorimetry are published. Our lab contributed to an international consortium in defining them.
www.nature.com/articles/s42...

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging - Nature Aging Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.

Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, and demonstrate their therapeutic potential in C. elegans and mouse models. @nataging.nature.com. www.nature.com/articles/s43...

A recycling mechanism that helps cells fight aging An international team led by EPFL has discovered a powerful anti-aging pathway in roundworms, revealing how boosting the cell’s lysosomes can help clear waste and promote healthy aging. The findings o...

Congrats to the Terytty, @arwengao.bsky.social and colleagues for identifying the importance of Lysosomal Surveillance Response (LysR) in fighting age-related protein accumulation. news.epfl.ch/news/a-recyc...
www.nature.com/articles/s41...

Can Saudi Arabia’s billions unlock the secrets to a longer, healthier life? Longevity has been an underfunded area of biotech research but that is changing thanks to an unlikely source: Saudi Arabia.

Johan Auwerx is featured in a piece on investing in the longevity economy. www.swissinfo.ch/eng/healthca...

Gut bacteria heal the colon EPFL scientists have uncovered how a gut bacterium, Clostridium scindens, aids in healing intestinal injuries by restoring bile acid balance. Their findings could pave the way for new treatments for u...

An interesting publication on #biotherapeutics to restore the compromised #bileacid signaling in ulcerative colitis! check it out! actu.epfl.ch/news/gut-bac...

The 2025 Health & Demography Conference is now open for virtual registration!
Longevity is reshaping societies and challenging long-standing norms. Join us as we discuss what is needed to thrive in an era of 100-year lives.
Register for virtual participation here: lnkd.in/dAS9viza

Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia The accumulation of ceramides and related metabolites has emerged as a pivotal mechanism contributing to the onset of age-related diseases. However, small molecule inhibitors targeting the ceramide de...

Another step in bringing ceramide lowering therapies to patients with muscle disease. Congratulations to Johanne, Ioanna, and Tanes for your valuable contributions.
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Four EPFL Professors Among Clarivate's Highly Cited Researchers Andrea Ablasser, Johan Auwerx, Gioele La Manno and Matthias Lutolf, four professors at EPFL’s School of Life Sciences, have been included in the prestigious list of most Highly Cited Researchers in 20...

We were selected again as a “Highly Cited Researcher” in 2024 by Clarivate. Thanks to all graduates for the hard work that enabled our continued success!
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