Tom Chad

SGLT2 and postop outcomes

There were significantly higher event-free survival probabilities for all-cause mortality, major adverse cardiovascular events, acute kidney injury and ketoacidosis in patients in the SGLT2 inhibitor group compared with controls

#AnSKy

doi.org/10.1111/anae...

In Our Time - The Evolution of Lungs - BBC Sounds From the mechanics of the first breaths on Earth to the reason we hiccup.

I think this came up in a recent FRCA SOE, so might be useful;

How do sauropods overcome large dead space volumes from having 10m long necks?

www.bbc.co.uk/sounds/play/...

ZODIAC trial: For ischemic stroke patients who are awaiting thrombectomy, flat positioning reduced the risk of neuroworsening or death

Premature termination but seems reasonable

Statistically robust results

Best available evidence; should change practice

pubmed.ncbi.nlm.nih.gov/40465238/ #EMIMCC

Remote ischaemic preconditioning and survival in noncardiac surgery: a meta-analysis of randomised trials Remote ischaemic preconditioning (RIPC) is an intervention involving brief periods of limb ischaemia to protect remote organs from subsequent ischaemic injury. Although evidence exists on the benefici...

www.bjanaesthesia.org/article/S000...

"PhD supervisors have two moods: [picture of heavily altered essay with red lines everywhere] [picture of guy with thumb up]

PhD student sends me this. Ouch.

Keeping fingers crossed for the methylene blue collection 🤞

Results of the #SESARtrial:

Among patients with moderate/severe ARDS, inhaled sedation with sevoflurane resulted in
- fewer ventilator-free days at day 28
- lower 90-day survival
than sedation with propofol.

Now published in JAMA jamanetwork.com/journals/ja...

@isicem.bsky.social #ISICEM25

Follow #CardioSky community by using starter packs

🦋 Cardiology Journals & Societies
go.bsky.app/FfE1QRm
🦋 CardioSky I
go.bsky.app/562nfhZ
🦋 CardioSky II
go.bsky.app/R2XckyG

Is it sad I’ve already named my career defining clinical trial (which someone will probably do before me) with one of those dodgy acronym titles

The Life Scientific - Sir Magdi Yacoub on pioneering heart transplant surgery - BBC Sounds Professor Sir Magdi Yacoub discusses his career at the cutting edge of transplant surgery.

Another very good episode www.bbc.co.uk/sounds/play/...

Very good trip to the Institut für Pathophysiologie @unidue.bsky.social to see their setup and learn lots of #langendorff

Mysterious Blobs in Cells Are Changing the Way We Understand Life Tiny specks called biomolecular condensates are leading to a new understanding of the cell

In the cover story of the February issue of @sciam.bsky.social I explain what biomolecular condensates are and why they are transforming cell biology. A short 🧵
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...

Sat in lab meeting recently fairly sure I was the most stupid person in the room. I hear it’s supposed to be a good thing but it was hard work 😮‍💨

Have struggled with ‘me time’ reading recently, so good to hear the writing style is so good. Always a bonus if compliments current work. Good luck with the new work!

Another insightful episode. I love these mostly because they often describe the hiccups and failures along the way, although listening to this Tim is supremely impressive. And yes I did try and fail at astronaut selection 👩‍🚀

podcasts.apple.com/gb/podcast/t...

Just ordered this thanks for the recommendation!

How to manage sodium-glucose cotransporter-2 inhibitors in the critically ill patient? - Intensive Care Medicine Intensive Care Medicine -

#SGLT2i use in critical care, icu-- interesting read

#SGLT2 inhibitors

#cardiosky #pharmsky #chf

link.springer.com/article/10.1...

go.bsky.app/4SkorDV

Have had a go at collating pack for those with #AnSky #intensivecaremedicine #criticalcare #anaesthetic #ICM and more general #research interests

Interested in the TBI subgroup in context of Hemotion trial, but O2 delivery probs not an issue here as still riding high on the oxy diss curve, and all had decent Hb values!

Christmas Music - Christmas Chill - The Sleeping Forecast: A Christmas Carol Special - BBC Sounds A dreamy bedtime escape with Charlotte Ritchie and serene music from BBC Introducing.

www.bbc.co.uk/sounds/play/...

On point for this eve

Assessment of Cardiac Function and Energetics in Isolated Mouse Hearts Using 31P NMR Spectroscopy Bioengineered mouse models have become powerful research tools in determining causal relationships between molecular alterations and models of cardiovascular disease. Although molecular biology is nec...

I like this idea of creating starling curves with increasing balloon volume in #Langendorff model

pmc.ncbi.nlm.nih.gov/articles/PMC...

Application of cardiac surgery techniques to improve the results of cardiopulmonary resuscitation after cardiac arrest: Controlled automated reperfusion of the whole body Until now, the overall results (survival and neurologic outcome) of cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) have been quite dismal. They have improved when compared with the outc...

When you think something might be a good idea only to find out someone has not only thought of it but developed kit/protocol/tested it clinically! Interesting preliminary work on ‘controlled automated reperfusion of the whole body’ (CARL) www.jtcvsopen.org/article/S266...

May have forgotten to add the tetrazolium to my tetrazolium assay

Have wondered if there is an economic and enviro value as well, even if ‘blind’ failure rate is low ish

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria - Nature Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...

Now that we are all here….this is a challenging paper- have we got cellular energetics under stress all wrong? www.nature.com/articles/s41...

New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle - PubMed In skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation, and in the regulation of the mitochond...

Have always been drawn to the role of carnitine in metabolic regulation, although multiple groups have tried and failed in sepsis

pubmed.ncbi.nlm.nih.gov/17331998/

Vasoconstriction with phenylephrine increases cardiac output in preload dependent patients - PubMed General Anaesthesia (GA) is accompanied by a marked decrease in sympathetic outflow and thus loss of vasomotor control of cardiac preload. The use of vasoconstriction during GA has mainly focused on m...

Try this pubmed.ncbi.nlm.nih.gov/38907106/

Very clear and concise paper highlighting some fundamental bedside physiology! Thanks for posting #AnSky

Check out our new educational hemodynamic adventure! We’ll add a new chapter every few weeks. #emimcc

A few years ago I posted this thread in the other place, reflecting on my PhD journey whilst prepping for my viva. Thought I should post it here now we are moving to Bluesky. Hopefully it's useful for aspiring researchers!

Reflections on taking time out of clinical training to pursue research: 1/n