Robert Screaton

Incretin receptor masterclass today in the 🇨🇦 National Graduate Course in #islet biology and #diabetes from experts @daveyboyhod.bsky.social and @danieljdrucker.bsky.social from cell biology to translational impact #GLP1R #GIPR

FORZA ITALIA

Progress in science depends on new techniques, new discoveries, and new ideas, probably in that order.

- Sydney Brenner

the latest on AI:

1. Language models are optimized for coherence, not truth

The core objective during training is to produce text that is likely and coherent given the context. That objective does not directly encode a concept of factual truth. As a result, the system can produce [garbage]...

harper came off the bag lol

This lecture was science in action: testing a model with rigor and an open mind. Collegial. Clear. 🏆.

a diagram of a cell with adp and atp synthase ALT: a diagram of a cell with adp and atp synthase

Today in the 🇨🇦 National grad course in #islet biology and #diabetes, experts Matt Merrins and Dick Kibbey from @yalepress.bsky.social stop by to discuss the latest in mechanisms of glucose coupling in the beta cell - it's all about the ATP! @utoronto.ca

Two cells isolated from a fish scale videoed through a DIC microscope. The cells are cool but now all I see are extracellular vesicles floating by in the media and stuck to the substrate....... #CellBiology

three men in suits are walking down a street ALT: three men in suits are walking down a street

Beta cell stress in #T1D and #T2D with experts @bruceverchere.bsky.social @thompsonisletlab.bsky.social and @mathieuferron.bsky.social coming in today for the 🇨🇦 #Islet biology and #diabetes grad course @utoronto.ca - defining metrics for beta cell recovery

Thanks Rob! Super fun class as always! Good to see some familiar faces too

a man in a tuxedo is holding a microphone and saying let 's get ready to . ALT: a man in a tuxedo is holding a microphone and saying let 's get ready to .

Today in the 🇨🇦 #Islet biology and #diabetes grad course we welcome experts @nkrentz.bsky.social and @drprentice.bsky.social who will discuss the pros and cons of common islet models as well as tissue crosstalk in #T1D and #T2D.

Join us in Toronto, July 13–16 for the inaugural International Conference on Neurogenesis & Repair!
Featuring keynote Jeffrey Macklis (Harvard) + global speakers.
13 competitive short talks, poster sessions, and separate trainee awards.
Early‑bird deadline: March 31.

Queued up in the 🇨🇦 National Graduate Course in #Islet Biology and #Diabetes today: experts @chrisadoucette.bsky.social and @theodoreds.bsky.social who will be discussing our current knowledge (and gaps!) on how #insulin actually gets out of a beta cell! Glucose coupling, circadian effects, and more!

🧬What if #betacells aren’t all the same?
Professor Andrew Pospisilik shares new epigenetic evidence that could reshape our understanding of #diabetes and #heterogeneity - from beta cell subtypes to #obesity endotypes.
📺Watch now:🔗 easd-elearning.eu/episode/359/...

This week FRIDAY JAN23 at NOON CST we are thrilled to welcome @glim2016.bsky.social from @umontreal.ca @crchum.bsky.social to the pharmacology seminar series speak "Can we identify 14-3-3 zeta inhibitors to treat type 1 #diabetes" @dream-diabetes.bsky.social Join us Via ZOOM: 660 7073 7150 PW:594459

a woman wearing sunglasses and a blue shirt is making a funny face and saying `` no autographs please '' . ALT: a woman wearing sunglasses and a blue shirt is making a funny face and saying `` no autographs please '' .

Today in the 🇨🇦 National Grad course in #Islet Biology and #Diabetes we welcome superstars Cristina Nostro and @yassiag.bsky.social to discuss the latest on using #stemcell derived islet cells as a strategy to treat (cure?) #T1D!

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Will be discussing science communication today in the 🇨🇦 National #Islet and Diabetes graduate course - using the #betacell secretion coupling debate as a case study! @utoronto.ca

a man in front of a microphone with the words we 're back on his face Alt: Neil deGrasse Tyson in front of a microphone mouthing the words "We're Back"

The 6th Annual 🇨🇦 National Graduate Course in #Islet Biology and #Diabetes hosted at @utoronto.ca kicks off today with 21 students and 30 outstanding lecturers from around the world. Today Drs. Wicklow and Gerstein will talk about #T2D and GDM in indigenous populations and the latest on #remission.

Study shows that neonatal #betacells sense gut microbiota-derived #bileacids via #FXR, limiting their development. Declining postnatal beta cell FXR expression allows normal neonatal beta cell growth and reduces #diabetes risk link.springer.com/article/10.1...

(please share) Immediate #postdoc job opening in the Millman lab at WashU Med (St. Louis, MO).

Want to develop next-generation pancreatic islets for the study and treatment of diabetes? Email your CV to apply

sites.wustl.edu/millmanlab/

Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells - Nature Communications Here they show that PPARα-dependent mitochondrial programming promotes the differentiation of pluripotent stem cell-derived β cells. Targeting mitochondria has the potential to improve β cell replacem...

Lietzke et al. demonstrate that pluripotent stem cell-derived β cells exhibit reduced oxidative and mitochondrial fatty acid metabolism compared to primary human islets, which is related to limitations in key mitochondrial transcriptional networks. 🧪
#PancSky

www.nature.com/articles/s41...

Download our large database of postdoc fellowships in all fields of research.

Database freely available to all; 281 fellowships.

Download here: research.jhu.edu/rdt/funding-...

Spatial and morphological organization of mitochondria in neurons across a connectome Neuronal function depends on mitochondria, but little is known about their organization across neurons. Using an electron microscopy Drosophila connectome, we uncovered quantitative rules governing th...

Spatial and morphological organization of mitochondria in neurons across a connectome | Science www.science.org/doi/10.1126/...

Our Novo Nordisk Research Chair in Equitable Care of Diabetes and Related Conditions, Dr. Baiju Shah, was interviewed about the importance of including diverse populations in research. Check out this video podcast from the T2D Network and @kristalamb.bsky.social!

www.youtube.com/watch?v=SGIG...

Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, includi...

How is #insulin production affected in residual beta cells in type 1 #diabetes? Préfontaine et al show unexpectedly that stressed senescent beta cells continue to produce mature insulin in the context of type 1 diabetes #DiabetesResearch #T1D #Islets link.springer.com/article/10.1... 🔓

Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social

Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine.

If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.

#sciencematters

Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - Diabetologia Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...

Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)