Organizado junto con el ๐๐จ๐ก๐๐ข๐ฅ-๐๐๐ฏ de la Conexiรณn y el grupo de ๐๐ผฬ๐๐ฒ๐ป๐ฒ๐ ๐๐ป๐๐ฒ๐๐๐ถ๐ด๐ฎ๐ฑ๐ผ๐ฟ๐ฒ๐ ๐ฑ๐ฒ ๐น๐ฎ ๐ฆ๐ผ๐ฐ๐ถ๐ฒ๐ฑ๐ฎ๐ฑ ๐๐๐ฝ๐ฎ๐ปฬ๐ผ๐น๐ฎ ๐ฑ๐ฒ ๐ ๐ถ๐ฐ๐ฟ๐ผ๐ฏ๐ถ๐ผ๐น๐ผ๐ด๐ถฬ๐ฎ (๐๐๐ฆ๐๐ )
๐ข ยกNueva informaciรณn sobre ๐ ๐๐๐ฅ๐ข๐ฃ๐๐ง๐๐ฆ ๐ฎ๐ฌ๐ฎ๐ฒ - MICRObiome PATHways for early-career Scientists! ๐ conexion-microbioma.csic.es
Evento sobre #microbioma para investigadores/as en etapas tempranas, que tendrรก lugar en la Sede del CSIC (Madrid)
Ayudas disponibles: @femsmicro.org y Conexiรณn Microbioma
What if tuberculosis wasn't just about Mtb anymore? Our new review just published in #GutMicrobes supports integrating the microbiome into TB prevention, diagnosis & treatment. A new path towards precision medicine in TB!
#BeyondBacilli #Microbiome
๐๐
www.tandfonline.com/doi/full/10....
Dr. Nadia Benaroudj was my PhD supervisor and she's an amazing scientist and a great person, don't hesitate to apply for her project!! ๐๐๐
๐ฌPPU 2025 Call for Candidates - Discover the PhD projects
Today's featured projects: 4 Cell Biology & Infection projects and 2 Parasites & Insect Vectors projects
๐ Applications deadline: October 20, 2025
๐Program starts: October 2026
Discover all projects & apply now: bit.ly/4nlPz8x
Des laurรฉats de Prix de These, de Poster, de Photo pour #MICROBES2025 qui mรฉritent leurs moment de gloire !
Fรฉlicitations ร tous et Toutes !
๐Session Remise des prix poster et des prix de thรจse pour lors de cette derniรจre journรฉe de #Microbes2025.
Fรฉlicitations ร tous les gagnants et merci aux participants !
Grateful as well to my beloved @pasteur.fr , the scientific home where I spent the last four amazing years doing #Science and #Microbiology!
Very much grateful for having received the #PhDPrize of the @jm-sfm.bsky.social @sfmicrobiologie.bsky.social. I truly feel honoured and I congratulate also my colleagues that participated in the same session: amazing microbiology at the forefront of Science!
#Microbes2025
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
En direct de l'audition du prix de thรจse de #Microbe2025, le premier candidat, Samuel Garcia Huete, nous a parlรฉ de l'adaptation รฉvolutive des Leptospira pathogรจnes au stress oxydatif ๐ฆ
Presenting my PhD work at the #Microbes2025 meeting of the French Society for Microbiology (SFM) for their #AnnualPhDPrize.
Spirochetes forever!
#Science
@pasteur.fr @sfmicrobiologie.bsky.social
Our second paper with @tcostalab.bsky.social and GoogleDeepMind
reports our experience with Googleโs co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AIโs potential to accelerate biology.
www.cell.com/cell/fulltex...
Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...
La blanca orilla. Y mas allรก, la inmensa campiรฑa verde, tendida ante un fugaz amanecer.
ยฟQuรฉ, Gandalf? ยฟQuรฉ se ve?
ยฟEl final? No, el viaje no concluye aquรญ. La muerte es sรณlo otro sendero, que recorreremos todos. El velo gris de este mundo se levanta y todo se convierte en plateado cristal. Es entonces, cuando se ve...
๐ฃBruno Sainz from #IIBM @csic.es receives substantial funding in the call for synergistic projects (CAM), together with @serranovillar.bsky.social -Ramรณn y Cajal Hospital/IRYCIS
โก๏ธReprogramming The Tumor Microenvironment Through Microbiome-Derived Immunomodulatory Molecules
Congratulations Bruno!!๐
Our latest efforts to understand Enterococcal wound infection. In long-term collaboration with @gthibault.bsky.social, we discovered how E. faecalis makes extracellular ROS - via EET!โก๏ธWhich in turn dysregulates host UPR to delay wound healing. Led by @aarontan.bsky.social - his videos below are ๐คฉ!
But the main question was still unanswered: how would a SOD-deficient pathogen face superoxide toxicity without the enzyme that always does the job?
Well, the answer, if you want it, is in our paper. Go check it out! ๐
๐๐
journals.asm.org/doi/10.1128/...
But we like to play: what happens if you return them the gene they lost? What happens if you give them back the SOD gene? Will they become more superoxide resistant? Surprisingly, they didn't!
See our Fig 2!
Evolution always goes first, so we figured that the ancestor of these bacteria had a SOD and that they lost it on their way to becoming pathogens... Interesting, right? Check our Fig. 1 here!
journals.asm.org/doi/10.1128/...
So we embarked on a risky adventure: we took one of these SOD-deficient pathogenic aerobes and decided not to leave the enterprise until we had an answer on how these organisms faced oxygen toxicity against all odds
Guess what? This organism was a spirochete: L. interrogans #SpirochetesAreDifferent
However, the advent of next-generation sequencing revealed hundreds of microorganisms across all branches of the tree of life that did NOT have any superoxide detoxification system, thus questioning everything again!
See Fig 1 in Sendra et al. Nat Eco Evol (2023)
www.nature.com/articles/s41...
In 1986, Carlioz & Touati finally proved that SOD-lacking E. coli could not grow in the presence of oxygen unless AAs were added to the media. This closed the debate, and similar observations were reported in yeast and Drosophila.
๐
pmc.ncbi.nlm.nih.gov/articles/PMC...
The seminal paper in 1979 by Fridovich & coll. predicted that aerobes must have superoxide detoxification systems, but this was highly controversial for over a decade (see James A Fee papers) until, in 1986, a milestone paper was published.
www.pnas.org/doi/abs/10.1...
Oxygen is toxic for living beings (believe it or not), but recent studies showed that 10% of them do not care much about it. We were convinced there was a missing key piece in this puzzle and, after hard work and countless thinking hours ๐ค, we think we have found an answer ๐๐งต
My first first-authored paper is now out ahead of print in #mBio. It was a loooong way between journals, but here we are with a result that I believe will be highly relevant for anyone interested in microbiology and evolution! ๐ฆ ๐งฌ
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journals.asm.org/doi/10.1128/...
