So great to see this work come out from my colleague's lab @cdsnow.bsky.social at CSU. Truly a dream-come-true innovation that will really accelerate X-ray structure determination. Applications are endless. Take a look and see if your protein of interest will work.
Stackreg will do it for you. But you may need to background subtract so it focuses on the thing moving and not on background stuff.
🔬🔦In this Imaging spotlight, Kevin Dean @kevin-dean.bsky.social and team tell us about their motivation for designing Altair-LSFM, describe its key features, how to setup and use the system and their planned developments.
focalplane.biologists.com/2026/03/09/i...
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302
The data is in: the NIH goalposts have shifted.
What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.
Another manifestation of how HHS policies have led to fewer awards and less science.
We have a new paper out today from superstar Nora Herzog!
A virus that fluidizes the nucleus to enable replication!
Check it out here:
lnkd.in/e-xV8acK
This was an amazing collaboration with Ian Mohr and Angus Wilson
It's been a privilege to be involved with this. #FRET approaches have so many potential applications for linking in vitro studies with in cell behaviours, but lacked a consistent benchmarking molecule that works across systems: not any more! #IDRs #smFRET #singlemolecule
Here’s a full draft of the upcoming second edition of my “Data Visualization: A Practical Introduction”: socviz.co
Join us in beautiful Portugal for the best & most comprehensive meeting on RNA localization and local translation! > 30 talks will be selected from abstracts. Held for over 30 years, this meeting is small enough to meet leaders in the field, yet big enough to cover a breadth of cutting-edge science.
Have you ever wanted to do single-molecule biophysics in high-throughput? @matt-dejong.bsky.social (amazing joint grad student with @dunnlab.bsky.social) invented a way & measured >100,000 single molecules across 241 different sequences. (1/3)
www.biorxiv.org/content/10.6...
heard from @projectsaltbox.bsky.social that #ICE is planning a Trump concentration camp in Hudson CO. Does anyone have intel? Protests happening? Our Dem. lawmakers at least are opposed. coloradotimesrecorder.com/2026/02/wher...
and y'all the tracker on @projectsaltbox.bsky.social is awesome.
3i is hiring a Microscopist - repost & tell a friend!
Ideal candidate has experience in fundamental optical theory & familiarity with lightsheet, spinning disk, multiphoton, TIRF etc. Full-time, exempt position (travel to visit customers) offering a competitive salary & comprehensive benefits.
Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps:
www.cell.com/cell/fulltex...
Rewrote my Python bioformats wrapper (from aicsimageio/bioio) as a standalone package:
- fully bootstrapped Java setup (just pip install)
- lazy, repeatably-indexable Array object
- fully spec-compliant OME-Zarr group obj.
- xarray/dask exports
github.com/imaging-form...
v0.0.rc1 on PyPI
Our collection presents a selection of research from scientists based in Japan.
Our model is designed to make publishing faster, fairer and more transparent, and this collection showcases research with global scientific contributions.
buff.ly/mUQxLxL
We are very proud that Thalia has been nominated for three Yorkshire Choice awards - Please vote here: www.yorkshirechoiceawards.co.uk/vote
Three years ago, Thalia was diagnosed with a devastating brain tumour. She has fought back and done her best to raise awareness and funds to support others!
Love this. Congrats.
Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity
With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule
rdcu.be/e3Ris
Out now in Cell Systems: We develop a technique to visualize influenza A virus in live cells with single viral RNA resolution. Combined with precise readouts of viral transcription, we map the whole influenza A viral life cycle and identify key bottlenecks in infection.
www.cell.com/cell-systems...
Beautiful work!
I’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...
In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...
🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...
Researchers are exploring new ways to harness the versatility of nanobodies, which are smaller camelid antibodies. @vivienm.bsky.social asked scientists about some of their current and future nanobody work.
www.nature.com/articles/s41...
and rdcu.be/e1yTd
New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos.
www.biorxiv.org/content/10.6...
Congratulations!!
This was a great chance to work with @IwasakiLabRiken to discuss the nearly perfect complementarity of Ribo-Seq and single molecule imaging studies of mRNA translation. I hope there are more studies in the future combining these two modalities to unravel translational regulation.
Yesterday, five-year-old Liam and his dad Adrian were released from Dilley detention center. I picked them up last night and escorted them back to Minnesota this morning.
Liam is now home. With his hat and his backpack.
Notice of Temporary Extension of Eligibility for the NIH Pathway to Independence Award (K99/R00):
for Individuals whose final due date was September-November 2025 and January-March 2026. As always, reach out to your PO/IC contact to discuss.
grants.nih.gov/grants/guide...
Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
Love this theory for why antibody generative models produce sequences with nice developability properties: it’s a reflection of PDB. ayusuf.substack.com/p/developabi....
This is a very nice example of one way of thinking about conditional generative models.
