🚨📃New Wassum Lab Paper📃🚨
Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇
www.nature.com/articles/s41...
Free full text: rdcu.be/eaxEv
1/12 How do animals build an internal map? In our new paper, we tracked thousands of mouse CA1 neurons over days/weeks as they learned a VR navigation task. @nspruston.bsky.social & co-1st author @johanwinn.bsky.social
Video: www.youtube.com/watch?v=yw_4...
Paper: www.nature.com/articles/s41...
I know this site only reaches a subset of neuro/ cog professors. If you know a young professor in the area who would benefit from a week of targeted learning about doing good science, good mentoring, networking etc, it would be great if you could forward them: compneurosci.com/Neuro4Pros/i...
Image of the Ko et al. article hosted on BioRxiv and a logo of the Cai Lab in the lower righthand corner.
📣 As promised, here is our protocol paper on chemotagging! This new technique combines calcium imaging with chemogenetics to identify cell types in commonly used Miniscope recordings & can be used to tag ANY CELL TYPE! #Neuroskyence
Read about the technique here: www.biorxiv.org/content/10.1...
Edvard Munch, The Scream
Apropos of everything 🌎, we're declaring it "Fear and Anxiety Week" here on Bsky. It's like shark week but better!
This week, we'll hear about fear and anxiety from brain researchers, psychiatrists, clinical psychologists, and individuals with lived experience.
We invite you to chime in! 1/n
schematic of neural recordings from mouse V1, whole-brain, and hippocampus; neural activity traces from the population, showing more correlated activity in V1 and whole-brain recordings versus more decorrelated activity in hippocampus
What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...
I'm delighted to share this special issue on scientific histories of hippocampal research in the journal Hippocampus - lots of interesting stories and a great resource for trainees. Huge thanks to Mike Hasselmo and Lynn Nadel for their vision and leadership! onlinelibrary.wiley.com/doi/toc/10.1...
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).
The renamed:
Bluesky-sized history of neuroscience (biased by my interests)
A graph of neurotransmitters along the x-axis and the likelihood they were submitted by a male PI along the y-axis
Is oxytocin really "a female hormone"?
Here's a snippet of something new I've been working on: an analysis of every (EVERY) neuroscience grant NIH has issued from 2013 - 2023. For grants focused on various hormones and neurotransmitters, here is the likelihood the grant had a male PI
Bummer that @zachtpennington.bsky.social is missing #ACNP2024 due to stomach flu. But be sure to check out his discovery about how the anterior hypothalamus codes stress 👇
This is one of the most important, surprising, and exciting findings I've been a part of!
Help bluesky neurohivemind!
If you know of any computational / theoretical work modelling neuromodulators please share it 🙏 if you don't, please retweet!
✋
I am excited that my first Bluesky post is to share our new paper in @natureportfolio.bsky.social - "Understanding the neural code of stress to control anhedonia." With @fxia.bsky.social , @valeriafascianelli.bsky.social and @stefanofusi.bsky.social. www.nature.com/articles/s41...
Question card
NIH Institute Directors session #ACNP2024
Hey #ACNP2024 attendees, UAB Neurobiology is looking to recruit 4 faculty in the areas of addiction neuroscience, iPSC/organoids, and neurodevelopmental disorders. All searches are open rank. Specific ads are forthcoming, but you can also apply at this link!
uab.peopleadmin.com/postings/18636
This was a hugely collaborative effort involving past and present Sheffield lab members. Feedback is very much appreciated!
Happy to share our work on CFC paradigms using head-fixed mice in VR. We elicited freezing as a conditioned response, making the paradigm comparable to freely moving setups and compatible with techniques requiring head fixation, like 2p microscopy/stimulation. #neuroscience 🧠 doi.org/10.1101/2024...
I am old so I can say this: innovation in neuroscience research can be accelerated if we did not waste so much resources repeating what we already know from NHP and rat research in Cre mouse lines
My paper is out!! 🎉
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
Review article on neural plasticity and antidepressant interventions
There are many nuances regarding the structural neural plasticity associated with antidepressant drugs. 💊🧠
We share our thoughts here in a Nature Reviews Neuroscience article, led by Clara Liao with co-authors from Conor Liston’s lab at Weill Cornell.
www.nature.com/articles/s41...
Terrific piece summarizing a recent report: Every dollar of NIH research funding doubles in economic returns
www.fiercebiotech.com/research/rep...
large-scale neural recording of 50,000 neurons, showing many diverse activity patterns, and also what the cells look like at various zooms of the maximum projection image of the recording FOV
We wrote a review on analysis methods for large-scale neural recordings www.science.org/stoken/autho... @marius10p.bsky.social #neuroscience 🧪🧠
Anything we missed? Reply w/ your fav method!
