@led3hub
LED3 is a hub of scientists working on early drug discovery at the Leiden Institute of Chemistry, the Leiden Academic Centre for Drug Research, the Institute of Biology Leiden and the Leiden Institute of Advanced Computer Science. @LED3hub@mstdn.science
We urgently need new antibiotics against the most devastating Gram-negative infections.
I am excited that Thomas Clairfeuille from Roche will visit us for a @led3hub.bsky.social Lecture on March 26th to talk about Zosurabalpin, a recent success story in the field.(1/2)
www.nature.com/articles/s41...
We are looking forward to the LED3 Lecture by Thomas Clairfeuille from Roche on March 26th. He will talk about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin"
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #Antibiotics #DrugDiscovery
It was great to be part of the discussion about the faculty priority themes of @leidenscience.bsky.social and to represent the @led3hub.bsky.social alongside @mvdstelt.bsky.social, Laura Heitman and @kimmb1.bsky.social.
Save the date! 15th Activity Based Protein Profiling meeting #ABPP2027 is in Leiden, 2-4th June 2027. Join the mailing list for program updates and rego: www.universiteitleiden.nl/en/science/led3/abpp2027
#chembiol #proteomics #ABPs #Chemicalprobes @led3hub.bsky.social @leidenscience.bsky.social
Our theme leader, @mvdstelt.bsky.social, introduces our LED3 hub at the meeting of all of our faculty priority themes of @leidenscience.bsky.social. Great discussions on the annual and communication plan and the outlook for the future. Exciting things ahead.
www.universiteitleiden.nl/en/science/l...
Interested in Activity-based Protein Profiling?
We are excited to host the 15th Activity-based Protein Profiling meeting (@abpp2027.bsky.social #ABPP2027) on June 2nd to 4th, 2027, at Naturalis in Leiden.
Save the date and sign up for our mailing list: www.universiteitleiden.nl/en/science/l...
We hope you all enjoyed Christina's talk as much as we enjoy sharing our science! Seems like it was a packed house 🫡
Amazing @led3hub.bsky.social Lecture by @thewoolab.bsky.social! She talked about her group's exciting work on protein C-terminal cyclic imids as natural ligands of cereblon for protein degradation. (1/3)
www.nature.com/articles/s41...
#TPD #DrugDiscovery #ChemBio #ChemSky #Degron
We are very happy that Christina Woo (@thewoolab.bsky.social) visited us for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
#TPD #ChemBio #ChemSky
@thewoolab.bsky.social at @led3hub.bsky.social seminar series on Rewriting Protein Modifications
#LED3
The Activity-Based Protein Profiling Conference #ABPP2027 is coming to Leiden on June 2nd to 4th, 2027.
Already mark your calendars! We hope to be able to welcome many of you in Leiden.
#DrugDiscovery #Automation #VirtualScreening #MedicinalChemistry #HitDiscovery #ChemSky #ChemBio
New preprint from our LED3 hub on ChemRxiv!
The labs of @sebastianpomplun.bsky.social , @gjpvwesten.bsky.social and Laura Heitman with first author @seanmckenna.bsky.social present COMBINAUT: an automated parallel synthesis platform for rapid access to 22.9M-compounds.
chemrxiv.org/doi/full/10....
How do mycobacteria assemble a highly impermeable outer cell envelope?
The group of Sebastian Geibel has elucidated the structure of two long-chain acyl-CoA carboxylases that are key to mycolic acid and complex lipid biosynthesis.
www.biorxiv.org/content/10.6...
#DrugDiscovery #cryoEM #Tuberculosis
Very much looking forward to the @led3hub.bsky.social Lecture by Christina Woo (@thewoolab.bsky.social)! I am sure it will be a great one.
If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.
#ChemSky #ChemBio #DrugDiscovery #degrader
We are looking forward to the LED3 Lecture of Christina Woo (@thewoolab.bsky.social) on February 26th. She will talk about "Rewriting Protein Modifications".
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #ChemicalProteomics #TPD
Great @led3hub.bsky.social Lecture by @anneosbourn.bsky.social. She talked about the amazing diversity of plant natural products, the gene clusters for their synthesis and their recombinant production for applications in #food and #health.
www.nature.com/articles/s41...
#Plants #NaturalProducts
We are very happy that @anneosbourn.bsky.social from the @johninnescentre.bsky.social visited us today for a LED3 Lecture. She talked about "Harnessing plant metabolic diversity for food and health applications".
#Plants #NaturalProducts #GeneClusters #DrugDiscovery #ChemBio #ChemSky #Food #Health
@anneosbourn.bsky.social (from @johninnescentre.bsky.social) is today’s @led3hub.bsky.social seminar speaker on Harnessing plant metabolic diversity for food and health applications
#NaturalProducts
Are you interested in cutting-edge research in Early Drug Discovery and Development?
We have a great program for our LED3 Lectures for the remaining academic year. Check out the program and mark your calendars!
www.universiteitleiden.nl/en/science/l...
#DrugDiscovery #ChemSky #ChemBio
We are looking forward to the LED3 Lecture of Anne Osbourn on January 29th She will talk about "Harnessing plant metabolic diversity for food and health applications".
If you are interested, make sure to come by!
www.universiteitleiden.nl/en/science/l...
#ChemBio #ChemSky #Plants #Metabolites
Our dean Jasper Knoester addresses our faculty @leidenscience.bsky.social in his New Year's speech. Interesting insights into the future strategic goals of our faculty and great to hear him highlight the priority themes including the @led3hub.bsky.social with new theme leader @mvdstelt.bsky.social.
The group of @mvdstelt.bsky.social of our @led3hub.bsky.social published CellEKT for profiling of the cellular targets of kinase inhibitors, which is further developed in the company Omivera (omivera.com). (3/12)
www.sciencedirect.com/science/arti...
The group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social developed self-encoded libraries (SELs) that allow affinity-selection MS-based screening of protein binders from large libraries in a single experiment without the need for a barcode. (6/12)
www.nature.com/articles/s41...
The groups of Nathaniel Martin of our @led3hub.bsky.social and the @smitslab.bsky.social published the powerful semisynthetic guanidino lipoglycopeptide EVG7 to treat Clostridioides difficile infections. (11/12)
www.nature.com/articles/s41...
Exciting news that @fda.gov has approved the first oral GLP-1 agonist for clinical use for @novonordisk.bsky.social.
www.novonordisk.com/content/nnco...
It was amazing to hear about the science behind these medications directly from Lotte Bjerre Knudsen in her @led3hub.bsky.social Lecture.
Excited to be part of the @led3hub.bsky.social of @leidenscience.bsky.social and of the organizing committee of the #LED3Lectures and #LED3Symposium. I am convinced that these are amazing initiatives that strengthen our collaborative spirit. New exciting activities are coming in 2026 and 2027.
We heard insightful LED3 Lectures by Paola Picotti, Andrea Rentmeister, Jeff Kelly, @jpoverington.bsky.social, Kim Lewis, Ed Tate, Jay Keasling, Willem Velema, Nicolas Winssinger and Lotte Bjerre Knudsen.(3/3)
#DrugDiscovery #Chemistry #Biology #PharmaceuticalSciences #ChemBio @unileiden.bsky.social
We are happy that we could continue our activities to bring our researchers closer together including the LED3 PhD/Postdoc Symposium #LED3Symposium and our flagship #LED3Lectures, in which we heard talks by a diverse selection of world-leading speakers in the field of #DrugDiscovery. (2/3)