Jeroen Guikema

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#Medsky🧪 #immunosky A RCT provides direct human evidence that the placebo effect can shape humoral immunity, showing that reward-related brain activity correlates with vaccine-induced antibody production & opening new avenues for treating many medical conditions.
Pdf www.nature.com/articles/s41...

Recombination between fragile regions associated with chromosomal rearrangements in glioblastoma can be mediated by RAGs - PubMed The RAGs, comprising RAG1 and RAG2, catalyze V(D)J recombination by recognizing recombination-signal sequences (RSS). Glioblastoma, the aggressive brain cancer, has many oncogenic chromosomal alterations; however, the mechanism of their generation is largely unknown. Here, we report that RAGs are ex …

pubmed.ncbi.nlm.nih.gov/41362770/

FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells
rupress.org/jem/article/... @jem.org

Levamisole-Mediated Suppression of B-Cell Proliferation and Antibody Production Reveals Mechanistic Insights into Idiopathic Nephrotic Syndrome Therapy Levamisole (LMS) is a small imidazole derivative with immunomodulatory properties. Despite its longstanding clinical use in Idiopathic Nephrotic Syndrome (INS), the mechanisms underlying its immune-re...

Happy to share a new online preprint on the immunomodulatory properties of levamisole, a steroid-sparing agent in children with relapsing idiopathic nephrotic syndrome. Joint work with Prof. Florquin & LEARNS clinical trial. tinyurl.com/nhd62mhw @amsterdamumc.bsky.social #research #kidney #B-cell

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.

Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!

www.nature.com/articles/s41...

a model for TIMELESS positions at the active fork: one complex sits at the leading edge of the fork, while the other one is on the lagging strand ssDNA/RPA, between the Okazaki fragments

Ever wondered how TIMELESS/TIPIN can sit at the leading edge of the replication fork regulating its speed, but also bind polymerases and ssDNA/RPA in replication stress? We have an idea how it might work! Check out our new preprint, any feedback is highly appreciated!
www.biorxiv.org/content/10.6...

Thrilled and grateful to share that our research team at Amsterdam UMC has been awarded a new research grant from the Dutch Cancer Foundation (KWF) to study the bone marrow niche in multiple myeloma. Extremely thankful to KWF for their continued trust and support of our work! #myeloma #research 🔬🩸

Save the date! On behalf of the Society, I’m delighted to announce that the next International Society for Evolution, Ecology and Cancer conference will be taking place in Hersonissos, Crete, on May 21-24, 2026. Abstract submissions will open soon. More details: www.evocancer.com

Vrijheid, Gelijkheid, Zusterschap

Laat de kracht van muziek werken in positieve zin. Een AI gegenereerd anti-AZC nummer is megapopulair.
Een tegenbeweging probeert nu het nummer Vrijheid, gelijkheid, zusterschap van Sophie Straat hoger te krijgen in de streaminglijsten. Helpen jullie mee? open.spotify.com/track/4EIM7Q...

Cautious or Protesting, Foreign Scholars Skip U.S. Conferences As President Donald Trump deploys National Guard troops to American cities and ICE arrests pick up, some international scholars are opting out of U.S. travel.

Foreign Scholars Skip US Conferences

“I don’t agree with the politicization of scientific funding, the destruction of data collection and openness... and I feel like traveling to America at this point is a partial endorsement of what’s going on,” Liston said.

www.insidehighered.com/news/faculty...

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake

go.nature.com/47zrzYZ

Scientists themselves determine what is valued within science. Yet we act as if beholden to external managers, bean-counters who confuse the production of papers with scientific progress.

We don't have to find better ways to navigate the prison of metrics-driven scientific assessment.

‼️Our latest study, “Loss of STAT3 in acute myeloid leukemia favors tissue infiltration linked to CXCR4 signaling,” is now out in @bloodneoplasia.bsky.social

#AML #STAT3 #CXCR4 #MLL-AF9
www.sciencedirect.com/science/arti...

Single-cell nascent transcription reveals sparse genome usage and plasticity scFLUENT-seq is a single-cell method that sensitively captures nascent nuclear transcriptomes to reveal mRNA and ncRNA dynamics, heterogeneity across chromatin compartments, and transcriptional divers...

"Surprisingly, individual cells—from splenic lymphocytes to pluripotent stem cells—transcribe only ∼0.02%–3.1% of the genome, versus >80% in bulk, revealing limited genome engagement and profound cell-type and cell-to-cell heterogeneity"

www.cell.com/cell/abstrac...

Do you know how badly things have to be going in America for us to be owned this hard by the Dutch? The Dutch of all people

What makes genes burst Genes burst. Instead of being monotonously transcribed by a steady stream of RNA polymerases, active genes undergo transient and random pulses of transcription that are referred to as gene bursting. This property is ubiquitous and evolutionarily conserved from bacteria to humans, and reflects the inherent stochastic nature of most biological processes. The frequency and duration of gene busting events varies greatly between genes and is now recognized to be controlled by an intricate interplay between transcription factors, chromatin features, and the transcription machinery. Recent findings also point to proximal regulation of bursting by epigenetic chromatin states, a novel role of non-histone modifications, and of distal control of bursting patterns by enhancers. Uncovering the regulatory mechanisms of gene bursting sheds light on how cells maintain a diverse range of gene-specific expression by modulating the different kinetic parameters of bursting.

What makes genes burst

APE1 active site residue Asn174 stabilizes the AP-site and is essential for catalysis Apurinic/Apyrimidinic (AP)-sites are common and highly mutagenic DNA lesions that can arise spontaneously or as intermediates during Base Excision Repair (BER). The enzyme apurinic/apyrimidinic endonu...

Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to Kaitlin Dehart and all the co-authors! Check it out: www.jbc.org/article/S002...

Excised DNA circles from V(D)J recombination promote relapsed leukaemia Nature - Excised signal circles are circular DNA by-products of V(D)J recombination that form a complex with the V(D)J recombinase, and when increased in abundance, result in increased mutagenesis,...

Excised DNA circles from V(D)J recombination promote relapsed leukaemia

Cutting your own DNA has a risk of leukaemia.

www.nature.com/artic...
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Pospelova et al. present a comparative analysis of adaptive immune loci across diverse mammalian species, uncovering relationships between locus architecture, characteristics of immune genes, and population dynamics. The artwork illustrates how the structure of immunoglobulin heavy chain loci influences gene variability in three representative species from the study – the mountain lion, the ring-tailed lemur, and European hedgehog.

Pospelova et al. present a comparative analysis of full-length sequences of IG/TR loci across 46 mammalian species, demonstrating these as rapidly evolving genomic regions, with implications for immunogenomics.

🔗 doi.org/10.1093/molbev/msaf152

#evobio #molbio

Respiratory viral infections awaken metastatic breast cancer cells in lungs Nature - Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by...

Respiratory viral infections awaken metastatic breast cancer cells in lungs

Note: This concerns many infections (inflammation, trauma), including respiratory viruses and is NOT specific for SARS-CoV-2 as some claim.

www.nature.com/artic...
1/9

Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding - Nature Communications Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer d...

Using barcodes 📊 to track cancer 💊 resistance evolution: is it clonal selection or plasticity? @fwhiting.bsky.social‬ knows! His new "Evolutionary Informed Resistance Assays" (EIRAs) framework infers resistance evolution dynamics from barcode diversity data. www.nature.com/articles/s41... @icr.ac.uk

Another tour de force by the Victora lab. A must read for germinal center aficionados. There goes the weekend!

Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company YouTube video by Amanpour and Company

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏

youtu.be/8YhJM6zxYDw?...

AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma Key Points. FOXO transcription factors and the GSK3 kinase are pivotal tumor suppressors restrained by AKT activity in MM cells.FOXO and GSK3 destabilize M

This aligns with findings from our lab where we show that AKT inhibition synergizes with MCL-1 inhibition to induce cell death in myeloma cells. ashpublications.org/bloodadvance...

Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention - Blood Cancer Journal Blood Cancer Journal - Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention

Interesting study on how to sensitize myeloma cells to the BCL2 inhibitor venetoclax by interfering with signal transduction pathways. #myeloma #science 🩸🔬https://www.nature.com/articles/s41408-025-01215-x

This is what we know about the so-called 'epithelial-mesenchymal transition'

'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts'
cellandbioscience.biomedcentral.com/articles/10....

"WE'VE ARRANGED A society based on science and technology, in which nobody understands anything about science technology. And this combustible mixture of ignorance and power, sooner or later, is going to blow up in our faces. Who is running the science and technology in a democracy if the people don't know anything about it?" "Science is more than a body of knowledge, it's a way of thinking. A way of skeptically interrogating the universe with a fine understanding of human fallibility. If we are not able to ask skeptical questions, to interrogate those who tell us that something is true, to be skeptical of those in authority, then we're up for grabs for the next charlatan, political or religious, who comes ambling along."

I think a lot about what Carl Sagan said in one of his final interviews.

And, again, WHERE IS #BIGPHARMA in defending #basicscience? laying low? playing dead? Waiting it out? Do SOMETHING! SPEAK UP! Use your gigantic lobbying machine to defend us instead of peddling your wares and increasing your profits. Or do you think highly trained workforce grows on trees?