Ahmed Eltanahy

Central neurons encode interleukin-1β signals and mediate stress-induced inflammation url: rupress.org/jem/article/...

Experience-dependent reconfiguration of thermoreceptors regulates neuronal response plasticity Harris, Dutta, et al. find that experience-dependent plasticity in the activation threshold of the AFD thermosensory neurons is mediated by modulating warm and cold thermoreceptor levels at the sensor...

Our first 2026 paper is out @currentbiology.bsky.social!
👏 to @nathancsharris.bsky.social (now Asst Prof, GA State) and PD Priya Dutta.

Here we show how transcriptional and trafficking pathways coordinate thermoreceptor levels to precisely modulate response plasticity
www.cell.com/current-biol...

Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.

#Throwback 🧪

PERSPECTIVE | Synthetic torpor: advancing metabolic regulation for medical innovations

W Wu, GA Sunagawa & H Chen

Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park!
“Specialized gas-exchange endothelium of the zebrafish gill” —

www.biorxiv.org/content/10.6...

Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)

Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...

Exploring pancreatic beta-cell subgroups and their connectivity - Nature Metabolism Rutter and Benninger discuss the role of putative controlling beta-cell populations in the context of intra-islet connectivity, how such a cellular hierarchy might be achieved and its potential role in islet physiology and diabetes.

#Throwback 🧪

REVIEW | Exploring pancreatic beta-cell subgroups and their connectivity

G Rutter, @bennyscience.bsky.social et al

When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.

A probabilistic histological atlas of the human brain for MRI segmentation - Nature NextBrain is an open source, probabilistic atlas of the entire human brain, assembled using artificial-intelligence-enabled registration and segmentation methods to reconstruct the multimodal serial h...

This is 🤯

All publicly available. Looks like an amazing new histology-based human probabilistic atlas and parcellation tool.

#neuroskyence #mri #brainmapping

A probabilistic histological atlas of the human brain for MRI segmentation | Nature share.google/5AD0iW7pxgb4...

Spatiotemporal gene expression and cellular dynamics of the developing human heart - Nature Genetics The authors use spatial and single-cell transcriptomics to examine spatial dynamics during early human cardiogenesis, yielding insights into the development of the cardiac pacemaker-conduction system,...

extraordinarily deep investigation of the human fetal heart with spatial and single cell approaches. With a comment by postdoc Lisa Iwamoto-Stohl and I. www.nature.com/articles/s41...
www.nature.com/articles/s41...

How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.

cell.com/immunity/ful...

Thanks and congratulations to all contributors

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway - Nature Neuroscience Buron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a hypothalamus–brainstem ...

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway

@julie.buron.bsky.social @inmed.bsky.social @insermpacacorse.bsky.social D54@incia-neurocampus.bsky.social

www.nature.com/articles/s41...

Region-specific drivers of CSF mobility measured with MRI in humans - Nature Neuroscience Brain clearance mechanisms are challenging to visualize in humans. Using magnetic resonance imaging, the authors noninvasively mapped cerebrospinal fluid motion across the brain, showing region-specif...

A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels

www.nature.com/articles/s41...

A brief guide to statistical analysis of grouped data in preclinical research - Nature Metabolism Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. Here, we explain how C&N arise, as well as valid designs and analyses.

#Throwback 🧪

COMMENT | A brief guide to statistical analysis of grouped data in preclinical research

@colbyvorland.bsky.social
L Golzarri-Arroyo
DB Allison

Astrocytic PIEZO activation by heartbeat sound promotes extracellular matrix and maturation in human brain organoids Heartbeat sound is one of the first rhythmic stimuli encountered by the developing human brain, yet its biological role has remained unexplored. Here we show that heartbeat sound promotes structural a...

"Here we show that heartbeat sound promotes structural and functional maturation of human cortical organoids with a physiological astrocyte-to-neuron ratio." 🤯 www.biorxiv.org/content/10.1...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.

#Throwback 🧪

COMMENT | Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics

KS Lee, X Su & T Huan

It’s not the thought that counts: Allostasis at the core of brain function The authors review evidence that the primary function of the brain, supported by distributed neural systems, is the predictive regulation of physiology (i.e., allostasis). An example from Alzheimer’s ...

It’s not the thought that counts: Allostasis at the core of brain function: Neuron www.cell.com/neuron/fullt...

This looks super cool; by @jtheriault.bsky.social
By the way congrats really!

Engineered 3D immuno-glial-neurovascular human miBrain model | PNAS Patient-specific, human-based cellular models integrating a biomimetic blood–brain barrier, immune, and myelinated neuron components are critically...

'This multicellular system with induced pluripotent stem cell-derived neurons, microglia, oligodendroglia, astrocytes, pericytes, and brain microvascular endothelial cells has potential for opening possibilities for disease modeling, drug discovery and development'
#Immunology #Neuroimmunology

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems Multi-Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential end....

🧠 A new era for brain #organoids! Researchers have created Multi-Region Brain Organoids that model human brain development more accurately by integrating cerebral, mid-hindbrain & endothelial regions.

advanced.onlinelibrary.wiley.com/doi/10.1002/...

#neuroskyence #devbio 🧪

Uridine Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar. In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP). Uridine can be produced through de ...

Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

a great not-to-miss piece from the @lyssiotislab.bsky.social

Excited to share our new paper out in @cp-neuron.bsky.social today! We discovered the neuroanatomical route that myeloid cells use to enter the brain parenchyma. Check it out here: authors.elsevier.com/c/1lCYs3BtfH...

Online now: A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses

Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Norepinephrine signals through astrocytes to modulate synapses Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

Norepinephrine signals through astrocytes to modulate synapses | Science www.science.org/doi/10.1126/...

Eltanahy et al. (University of Nevada) used Mightex’s #PolygonDMD Illuminator to reveal how violet light (405 nm) regulates ocular fluid balance via calcium signaling and choroid pressure dynamics. Precision light control in action!
👉 Read more here: www.mightexbio.com/light-sensit...

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour - Nature A distinct population of CD4 T cells resides in specific regions of the steady-state brain, and these T cells are programmed in the periphery by the microbiome to coordinate adaptive behaviour.

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour

www.nature.com/articles/s41...

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development Nature Neuroscience - The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism...

Led by @scienceyael.bsky.social & out today in @natneuro.nature.com: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread
rdcu.be/eoaSY

Niche-specific therapeutic targeting of myeloid cells in the central nervous system In this review, Prinz and Frosch describe how the central nervous system is partitioned into distinct immune niches, each hosting unique myeloid cell populations that shape disease outcomes. They highlight novel cellular and molecular strategies to modulate these populations in a compartment-specific manner and discuss the challenges in translating these approaches from animal models to clinical practice.

Online now: Niche-specific therapeutic targeting of myeloid cells in the central nervous system

A neuroimmune circuit mediates cancer cachexia-associated apathy Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...

1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...

Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervous system - Nature Cell Biology Han et al. report the existence of neural stem cells (NSCs) outside the central nervous system and show that these peripheral NSCs display features similar to brain NSCs, including the ability to diff...

Interesting finding that neural stem cells exist outside the brain/spinal cord-in tissues like lung & tail-and share key properties with brain NSCs, challenging current dogma.

Wonder if these NSCs exist in humans & can show similar therapeutic potential

www.nature.com/articles/s41...

NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection - Nature Metabolism Krapić, Kavazović and colleagues dissect the mechanism by which natural killer cells drive adipose tissue remodelling during viral infection, thus fuelling antiviral immune responses.

And here is the link to the original research paper from Krapić, et al: www.nature.com/articles/s42...