A 3D multi-compartment assembloid to study
combined immune cell infiltration and cytotoxicity
Contains different compartments with different ECM.
Especially useful to test infiltration and cytotoxicity of CAR T cell therapies.
More here: www.cell.com/cell-reports...
Force generated by blood flow in developing embryos dictates a bioenergetic switch (increased mTORC1 & mitochondrial genes) necessary for hematopoietic stem cell emergence @jem.org @uthealthhouston.bsky.social
rupress.org/jem/article/...
We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.
An illustration of a man giving a woman a door, with text: How I balanced my Ph.D. research with opening doors for others.
"In the face of these challenges, I felt more strongly than ever that I should help open doors for others."
In this #ScienceWorkingLife, Edgar Virguez writes about working to make academia more inclusive while balancing #PhD research. https://scim.ag/3WRLJIL #InternationalStudentsDay
Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment.
The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply. #NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIV @natimmunol.nature.com
www.nature.com/articles/s41...
Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
Check out this @nature.com paper from the brilliant scientist I get to call my husband!!!!
Impaired stromal-epithelial cross-talk in Hirschsprung disease highlights the risk of epithelial damage, suggesting a therapeutic option
www.science.org/doi/10.1126/...
Every cell is a stem cell!
Even ‘terminal’ enterocytes can hit reset: Gut damage triggers a YAP/TAZ-driven fetal program → stress-proof “revival” stem cells → Lgr5⁺ CBC stem cells, rebuilding crypts from scratch and make organoids.
#StemCellPlasticity #Organoids #Gut
Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells @natcomms.nature.com
www.nature.com/articles/s41...
Our July issue is out today!
Cover art depicts precision antibacterial strategies that allow non-toxigenic V. cholerae to dominate toxigenic rivals.
www.cell.com/cell-host-mi...
I'm excited about a new @biorxivpreprint.bsky.social story that just went live! This one takes a #computational #immunology approach to understanding #tissueresident lymphocytes. The story highlights the extra value mathematical modelling can bring to biology. 🧵1/10
www.biorxiv.org/content/10.1...
And NIH scientists know this better than anyone.
www.nature.com/articles/s41...
Excited to share this fun perspective on perinatal mucosal immune development! Check it out ➡️ www.sciencedirect.com/science/arti...
Spatial single-cell analysis identifies #placental villi structural and immune remodeling across #gestation from @konnikovalab.bsky.social
www.mucosalimmunology.org/article/S193...
RFK Jr. removes all members of CDC panel advising U.S. on vaccines
predictable, but still extremely harmful for anyone. Infectious diseases will come back, they cannot be prevented but for preparing our immune system to control and fight them.
www.cnbc.com/2025/06...
1/3
🚨 A new rule would let career scientists like NSF/NIH program officers be replaced by political appointees
Already 14,000+ public comments, deadline is Friday
📣 Comments can be short. Courts consider them—and scientists with NSF/NIH experience are especially impactful
Speak up! shorturl.at/WKuBj
Fetoplacental extracellular vesicles deliver conceptus-derived antigens to maternal secondary lymphoid tissues for immune recognition @jci-insight.bsky.social
insight.jci.org/articles/vie...
We are #hiring! Please help share!
Postdoc in #Immunology; B-cell biology
We are recruiting a postdoc to lead projects on human B cells and plasma cells funded by the Gates Foundation and the NIH (The position is fully funded and not dependent on future grants).
ghosnlab.science/join-us
The Sengupta lab is seeking research technicians to join its team. Ideal candidates must possess a passion for research and exceptional communication skills. Both early-career and experienced candidates are welcome. Email SenguptaS@chop.edu with CV and letter of interest with goals and expectations.
So I took a deep dive.
New research shows public science delivers 140–210% returns and fueled 20% of U.S. productivity growth since WWII.
Cuts now = $billions lost later.
www.forbes.com/sites/johndr...
"to run a contest that you end up not funding as a private organization at this time is… both extremely wasteful of these people’s time, and just devastating in terms of morale."
I spoke with @aniloza.bsky.social at STAT today about HHMI's decision not to fund this round of Hanna Gray applicants.
🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.
📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025
Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social
#EMBOBarrierTissues
I will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!
Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism"
—the 1st human to undergo custom genome editing
—from decades of NIH funded research
www.nejm.org/doi/full/10....
@nejm.org
www.nejm.org/doi/full/10....
www.nytimes.com/2025/05/15/h...
Well the NIH has cancelled the Women's Health Initiative, the largest study of women in history
It has been running continuously since 1991 and has provided massive key knowledge about diseases in women
Unreal
www.science.org/content/arti...
Phylogenetic analysis of Artemis, SNM1A and SNM1B across eukaryotes. Top left: A Bayesian tree was constructed by MrBayes based on the MBL and β-CASP domains of Artemis, SNM1A and SNM1B. Numbers indicate the posterior probability. Top right: a multiple sequence alignment of Artemis proteins, alongside mouse SNM1A and SNM1B. Conserved residues were highlighted by red background. Black stars indicated the conserved residues composing motif I-IV and motif A-C in Artemis. Bottom: Intron phase composition of Artemis from invertebrate and vertebrate representatives was shown. On the left, colored rectangles in light orange, light blue and light yellow represent three distinct intron phases, respectively. On the right, colored rectangles in orange, light green and gray correspond to the MBL, β-CASP and C-terminus domains of Artemis protein, respectively.
Evolutionary analysis of the #nuclease Artemis suggests an important role in the domestication of RAG-like #transposons, such as that which gave rise to V(D)J recombination. Conserved residues crucial for nuclease activity are also identified @plosbiology.org 🧪 plos.io/3RuyNpl
total; nsf grfs 2021-2015
nsf GRFS by major field 2021-2025
Quick look at NSF GRFPs awarded 2021-2025. Overall 50% drop from 2024, with biggest absolute decreases in engineering, life sciences and chemistry.
(sorry about the meh viz, in a hurry)
Great coverage of the recent JEM paper by @hlpeks.bsky.social, @emmaschambers.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin, and colleagues. See the original paper here: rupress.org/jem/article/...
