Yi-Chun Chen/YCC

SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) is a regulator of PC2 biology and an essential mechanism for maintaining α cell function and glucagon biosynthesis www.nature.com/articles/s41...

Beta cell function and mass in individuals with and without remission of type 2 diabetes after Roux-en-Y gastric bypass - Diabetologia Aims/hypothesis In people with type 2 diabetes and obesity, Roux-en-Y gastric bypass (RYGB) can induce remission of diabetes. While RYGB has been reported to improve beta cell function in individuals ...

Individuals with remission of type 2 diabetes after RYGB have better beta cell function than those not achieving remission, but the groups did not differ with respect to beta cell mass. link.springer.com/article/10.1...

Quantitative analysis of human adult pancreatic histology reveals separate fatty and fibrotic phenotypes in type 2 diabetes - Diabetologia Aims/hypothesis The role of intra-pancreatic lipid and collagen in type 2 diabetes pathogenesis remains unclear. We sought to examine this in pancreases from organ donors with and without diabetes. Me...

Up front & free to read in our Dec issue #editorspicks: Quantitative analysis of human adult pancreatic histology reveals separate fatty and fibrotic phenotypes in type 2 diabetes link.springer.com/article/10.1...

ICYMI: This issue’s cover features work by Mustafa Tekin & team reporting on changes in the carboxypeptidase D gene as a cause congenital hearing loss by harming inner ear cells—with implications for targeting the nitric oxide pathway as a therapeutic strategy: doi.org/10.1172/JCI1...

Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...

Here deletion of Xbp1 in β-cells (Xbp1β-/-) of non-obese diabetic mice before insulitis is protective against #diabetes
www.nature.com/articles/s41...

Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - Diabetologia Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...

Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓

New insights into islet ER stress responses, proinsulin biosynthesis, ERAD and ERD1 using β-cell-specific Hrd1-KO mice & rodent (and human islet) β-cells treated acutely with HRD1 inhibitor. jci.org/articles/vie...
@jci.org

🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100…
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social

Children born to mothers with T1D are less likely to develop T1D than those with an affected father or sibling- linked to changes in DNA methylation at T1D risk genes

The interaction of GLP-1 medicines with the immune system is complex, enabled by direct and indirect actions, including neural inter organ communication. These studies have been led @SinaiHealth by CK Wong. His latest perspective here in the JCI www.jci.org/articles/vie...

Tuning insulin receptor signaling using de novo-designed agonists Wang, Cardoso, and Cai et al. design synthetic insulin receptor agonists that impose distinct receptor conformations, leading to modulated signaling. These agonists outperform insulin in metabolic con...

www.cell.com/molecular-ce...

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

💫NEW: @buszczaklab.bsky.social @jun-wu-lab.bsky.social & co use human #brain #organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired #ribosome production and protein synthesis, and delayed radial glial cell specification.
bit.ly/4lvVBBP

Amylin receptor subunit interactions are modulated by agonists and determine signaling Agonist-dependent interactions between a GPCR and its accessory proteins affect signaling by peptide hormones.

Amylin and calcitonin differentially affected AMYR subunit assembly and disassembly in a RAMP-specific manner www.science.org/doi/10.1126/...

Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice D-lactate from the gut microbiota influences blood glucose and fatty liver disease. Trapping D-lactate in the gut improves blood glucose and lowers liver inflammation and fibrosis during obesity.

Here Professor Schertzer and colleagues identify that microbial-derived D-lactate contributes to host glucose and lipid metabolism and can be trapped therapeutically to improve metabolic disease during #obesity www.cell.com/cell-metabol...

Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes In type 1 diabetes (T1D), insulin (INS) deficiency results from immune-mediated destruction of β-cells. The majority of functional β-cell mass is typically

Smaller islets are preferentially lost during the development of T1D
diabetesjournals.org/diabetes/art...

Happy Canada Day! 🇨🇦 I'm excited to be part of this special topic and thrilled to share our work with the public. Research matters, and we truly appreciate the support from everyone involved, including the government and funding agencies.

Breakthrough T1D Walk 2025 in Saskatoon 🩵💙🩵

www.jci.org/articles/vie...

ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion Using in vitro models of lipotoxicity and islets from the db/db mouse model of type 2 diabetes (T2D), we show that endoplasmic reticulum (ER) stress i…

www.sciencedirect.com/science/arti...

Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus - Nature Reviews Endocrinology Amylin is a peptide hormone involved in satiation. Amylin mimetics have potential as therapies for obesity and diabetes mellitus, but clinical development has proven challenging. This Review discusses...

Amylin returns to the metabolic stage with a more powerful story to tell #weightloss @natrevendo.nature.com www.nature.com/articles/s41...

The metabolic syndrome and young-onset dementia, from a nationwide cohort of ~2 million people
www.neurology.org/doi/abs/10.1...

Check out our recent review describing the bidirectional regulation between the ER and mitochondria
www.mdpi.com/3216548

Tools for transformation: a teaching toolkit and research pocket guide for advancing equity, diversity, and inclusion in science and engineering Advancing equity, diversity, and inclusion (EDI) in scientific fields is an outstanding challenge. While there is growing awareness of barriers and challenges to EDI across science, technology, engine...

It was a pleasure to co-author this article alongside amazing folks at Carleton. Please check out our EDI resources!

Tools for transformation: a teaching toolkit and research pocket guide for advancing equity, diversity, and inclusion in science and engineering www.facetsjournal.com/doi/10.1139/...

Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay Insulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

More data highlighting insulin mRNA decay and the extent of ER stress in beta cells linked to the pathophysiology of #T1D #genetics @cellcellpress.bsky.social www.cell.com/cell/fulltex...

Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice Targeting beta cell proliferation is an appealing approach to restore glucose control in type 1 diabetes. However, the underlying mechanisms of beta cell proliferation remain incompletely understood, ...

Excited to share our publication in @cp-iscience.bsky.social
Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice #IMM @uthealthhouston.bsky.social @bcmhouston.bsky.social 🧵 www.cell.com/iscience/ful...

Assistant or Associate Professor - Western College of Veterinary Medicine Tenure track position in physiology, pharmacology and/or toxicology at the Western College of Veterinary Medicine

WCVM is hiring a TT assistant/associate professor: wcvm.usask.ca/departments/... (Saskatoon is beautiful- even in the winter☺️)

Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity - Diabetologia Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome–IL-1β pathway is observed in obesity and contributes to the development of type 2 diabetes and its compli...

Up front & free to read in our Jan issue #editorspicks: Targeting the NLRP3 inflammasome–IL-1β pathway in type 2 diabetes and obesity tinyurl.com/bdf9ec33

Thanks! :)

Saying goodbye to Vancouver 🥺