Eleftheria Papadopoulou's Avatar

Eleftheria Papadopoulou

@papadopoulou

IMPRS-ML student in Schulman lab, Max Planck Institute of Biochemistry๐Ÿงช BIF PhD Fellow ๐Ÿ”ฌ Interested in Ubiquitin, Protein Degradation and Molecular Signaling ๐Ÿ‘ฉ๐Ÿปโ€๐Ÿ”ฌ

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15.11.2024
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Latest posts by Eleftheria Papadopoulou @papadopoulou

Kiss-intro IMPRS-LM stands for International Max Planck Research School for Living Matter. We are interested in the molecular, chemical and physical properties

You are passionate about ubiquitin, proteostasis and cellular biochemistry and want to be part of a collaborative, ambitious, excited and fun team? I am recruiting PhD students via the @imprs-lm.bsky.social graduate school:
www.imprs-lm.mpg.de/index.php/le...
(2/3)

05.03.2026 11:00 ๐Ÿ‘ 15 ๐Ÿ” 10 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code!
There are multiple open positions!
(1/3)

05.03.2026 11:00 ๐Ÿ‘ 83 ๐Ÿ” 22 ๐Ÿ’ฌ 11 ๐Ÿ“Œ 4
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Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells!
Read our paper @cp-cell.bsky.social!

โ•Publication: doi.org/10.1016/j.ce...
โ•Press Release: www.biochem.mpg.de/en/pressroom

@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet

28.01.2026 16:39 ๐Ÿ‘ 69 ๐Ÿ” 26 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 2
A CK2-FBXW11 kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating Tryptophan 2,3-dioxygenase stability Small molecules toggling the ubiquitin-proteasome system (UPS) are powerful regulators of protein degradation. Yet, mechanistic knowledge of how endogenous ligands gate UPS decisions remains rudimentary. Here, we define control of UPS access to Tryptophan-2,3-dioxygenase (TDO2), which converts the essential amino acid tryptophan (Trp) to N-formylkynurenine. When Trp concentrations are limiting, TDO2 is degraded to avert tryptophanemia. Using CRISPRi screening and biochemistry, we identify a CK2-FBXW11 kinase-E3 ligase cascade that generates and recognizes tandem TDO2 phosphodegrons when not protected by Trp. Trp binding to an exosite safeguards TDO2 from phosphorylation-dependent ubiquitylation. Effects of Trp analogs on CK2-FBXW11-dependent ubiquitylation indicated that the indole, amino, and carboxylate groups are necessary for substrate shielding. Cryo-EM reveals how these moieties order a region proximal to the phosphodegrons; without Trp, this segment is flexible, enabling phosphorylation-coupled ubiquitylation. Overall, our data uncovered an endogenous small molecule allosterically stabilizing its own metabolizing enzyme through protection from a phosphorylation-ubiquitylation cascade. ### Competing Interest Statement B.A.S. is a member of the scientific advisory boards of Proxygen and Lyterian. The other authors declare no competing interests. Max Planck Society, https://ror.org/01hhn8329 European Union, ERC AdvG, UPSmeetMet, 101098161 to BAS Boehringer Ingelheim Fonds, https://ror.org/00dkye506

New year, new preprint! ๐ŸŽŠ

We are excited to share our recent work on #E3 ligase regulation in #metabolism!

www.biorxiv.org/content/10.6...

#ubiquitin #targetedproteindegradation #chemicalbiology

1/6

13.01.2026 13:49 ๐Ÿ‘ 43 ๐Ÿ” 17 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 5
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When RNA Degradation ๐Ÿค meets ๐Ÿค Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).

06.01.2026 08:04 ๐Ÿ‘ 117 ๐Ÿ” 50 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 4
Black and white photo of James Watson

Black and white photo of James Watson

James (Jim) Watson, LMB Nobel laureate, co-discoverer with Francis Crick of the structure of DNA, has died at the age of 97.
www2.mrc-lmb.cam.ac.uk/james-watson...
#LMBNews #LMBAlumni

08.11.2025 11:06 ๐Ÿ‘ 11 ๐Ÿ” 3 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 1

Congrats Filiz ๐Ÿฅฐ

20.09.2025 12:59 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Structural basis of an EMC:Spf1 insertase-dislocase complex in the eukaryotic endoplasmic reticulum Most eukaryotic membrane proteins are inserted into the membrane at the endoplasmic reticulum (ER). This essential but error-prone process relies on molecular quality control machineries to prevent mi...

Super excited to share our new #preprint on #BioRxiv โœจ
We reveal the structural basis of a partnership between the ER membrane complex (EMC) and the P5A-ATPase Spf1 โ€” an insertaseโ€“dislocase duo that coordinates membrane protein biogenesis and quality control.
www.biorxiv.org/content/10.1...

11.08.2025 12:35 ๐Ÿ‘ 24 ๐Ÿ” 7 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 1

Congrats Felix!!!๐ŸŽ‰๐ŸŽ‰

12.08.2025 11:52 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Hi there! Our group at LMU Munich is hiring a postdoc to work on Toxoplasma and Plasmodium.
Start: from Oct 1, 2025 | Location: Munich, Germany
1-year contract with extension possible
Apply by Aug 31: bit.ly/LMUpostdoc
Contact: elena.jimenez@lmu.de

08.08.2025 06:40 ๐Ÿ‘ 6 ๐Ÿ” 5 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Check out this amazing paper from @carolinklose.bsky.social ! Congrats to all the authors ๐ŸŽ‰

07.08.2025 11:20 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐Ÿ“ฃ Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org
#ubiquitin

11.07.2025 07:08 ๐Ÿ‘ 14 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Excited about #Ubiquitin and protein degradation?

Have a look at my recent talk at the @danafarber.bsky.social Targeted Protein Degradation Webinar Series now out on YouTube. Here, I talk about my recent publication (see Blue-torial below)

www.youtube.com/watch?v=Cpg0...

09.07.2025 08:13 ๐Ÿ‘ 29 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Excited about #ubiquitin and #TPD ?
Then join us tomorrow for the latest instalment of the @danafarber.bsky.social โ€ฌ Targeted Protein Degradation Webinar where Kimberly Stegmaier and I will present our latest work.
dfci.zoom.us/webinar/regi...

25.06.2025 21:08 ๐Ÿ‘ 13 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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IMPRS-ML graduate @sofiatodesca.bsky.social shares her experience:
๐Ÿ”ธ Reasons for applying to the program
๐Ÿ”ธThoughts about the curriculum
๐Ÿ”ธOpinion on the student life / networking opportunities
๐Ÿ”ธView on the scientific community in Munich

Learn more here: imprs-ml.mpg.de

#phdlife #imprssiveminds

25.06.2025 07:52 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Check out our latest study @natsmb.nature.comโ€ฌ: Establishing a consensus model for #ubiquitin chain assembly by HECT #E3 ligases: #cryoEM structures of #TRIP12 forming K29-linked and K29/K48-branched chains!

โ• www.nature.com/articles/s41...

@samuelmaiwald.bsky.social @unileiden.bsky.social

26.05.2025 14:36 ๐Ÿ‘ 8 ๐Ÿ” 4 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Check out this amazing paper from @samuelmaiwald.bsky.social! Congrats to all the authors ๐ŸŽ‰

#TRIP12 #E3ligases #SchulmanLab

26.05.2025 11:15 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

MPI Mensa at its greatest ๐Ÿ˜‚

03.04.2025 15:35 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss etย al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

Super excited to share our latest work on deciphering the #Ubiquitin Code

โ€œ๐—จ๐—ฏ๐—ถ๐—ฅ๐—˜๐—”๐—— ๐—ฑ๐—ฒ๐—ฐ๐—ถ๐—ฝ๐—ต๐—ฒ๐—ฟ๐˜€ ๐—ฝ๐—ฟ๐—ผ๐˜๐—ฒ๐—ฎ๐˜€๐—ผ๐—บ๐—ฎ๐—น ๐—ฑ๐—ฒ๐—ด๐—ฟ๐—ฎ๐—ฑ๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ฐ๐—ผ๐—ฑ๐—ฒ ๐—ผ๐—ณ ๐—ต๐—ผ๐—บ๐—ผ๐˜๐˜†๐—ฝ๐—ถ๐—ฐ ๐—ฎ๐—ป๐—ฑ ๐—ฏ๐—ฟ๐—ฎ๐—ป๐—ฐ๐—ต๐—ฒ๐—ฑ ๐—ž48 ๐—ฎ๐—ป๐—ฑ ๐—ž63 ๐˜‚๐—ฏ๐—ถ๐—พ๐˜‚๐—ถ๐˜๐—ถ๐—ป ๐—ฐ๐—ต๐—ฎ๐—ถ๐—ป๐˜€โ€

@cp-molcell.bsky.social

1/8

www.cell.com/molecular-ce...

24.03.2025 14:54 ๐Ÿ‘ 131 ๐Ÿ” 44 ๐Ÿ’ฌ 16 ๐Ÿ“Œ 4

Congrats @leokiss.bsky.social ๐ŸŽ‰๐ŸŽ‰

24.03.2025 16:35 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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We're just one month out from <interact>!

Talk and poster submission windows are now closed. We would like to thank you for all your submissions!

Spots at <interact> are limited! Be sure to sign up early (and there may be something special in store for you too).

03.03.2025 12:22 ๐Ÿ‘ 6 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐Ÿ“ข Abstract submissions for student talks for <Interact>2025 have officially closed! We'd like to massively thank you for all your submissions!

By popular request, we have extended the submissions for posters abstracts by an extra week!

Sign up by visiting us at:
www.munich-interact.de/register

24.02.2025 11:49 ๐Ÿ‘ 5 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐Ÿ“ขโ€ผ๏ธFinal call for student talk abstract submissions!
Don't miss out on the opportunity to present your science and win attractive prizes!

Mark your calendars: April 3-4, 2025
Venue: Biomedical Center (BMC), LMU Munich

To sign up, visit our website: www.munich-interact.de/register

23.02.2025 10:29 ๐Ÿ‘ 4 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Interact Munich 2025 PhD conference, interact 2025, organised in Munich, Germany. Great opportunity for PhD candidates to network with fellow early career researchers and learn about their future career opportunities.

Weโ€™re thrilled to welcome Prof. Dr. Lukas Milles (@lfmilles.bsky.social) as our keynote speaker! With a background in de novo protein design, deep learning, and biophysics, his talk will dive into the cutting-edge world of AI-driven protein engineering. ๐Ÿงช

21.02.2025 10:27 ๐Ÿ‘ 7 ๐Ÿ” 3 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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โŒ›๏ธ9 days left to register for our #WUeBi2025 conference!โŒ›๏ธ

Countdown started: in the next 9 days we will announce our amazing speakers here - so stay tuned!

Today starting with our Keynote speakers Brenda Schulman from @mpibiochem.bsky.social and Tom Rapoport from @harvardmed.bsky.social

20.02.2025 08:50 ๐Ÿ‘ 9 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Congratulations to Arno Alpi and Peter Murray for the FEBS Letters Award 2025. ๐ŸŽ‰

โ• Further information: febs.onlinelibrary.wiley.com/hub/journal/...
โ• Award-winning publication: febs.onlinelibrary.wiley.com/doi/10.1002/...

18.02.2025 17:15 ๐Ÿ‘ 12 ๐Ÿ” 4 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

๐Ÿ’ก Whether it's a breakthrough discovery or an interesting theory, we want to hear from YOU.

๐Ÿ“… Deadline: 24.02.2025 0:00 CET
๐Ÿ“ Submit your abstract here: munich-interact.de/register

Make sure to get your submission in before time runs outโ€”let's make this conference unforgettable! ๐Ÿ”ฌ

#interact2025

18.02.2025 09:25 ๐Ÿ‘ 2 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

๐Ÿšจ Last Week for Abstract Submissions! ๐Ÿšจ

The clock is ticking! โฐ This is your final chance to submit your abstract for <interact> 2025 before the deadline. Donโ€™t miss the opportunity to share your research, innovations, and ideas with an incredible community of thinkers and professionals.

18.02.2025 09:25 ๐Ÿ‘ 1 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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โœจ Introducing Our First Keynote Speaker! โœจ

We are thrilled to welcome Ranga Yogeshwar as a keynote speaker at Munich Interact 2025! ๐ŸŽค

15.02.2025 16:05 ๐Ÿ‘ 4 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Instagram Create an account or log in to Instagram - Share what you're into with the people who get you.

Something cool is happening on our Instagram page! Don't miss out on the chance to win 2 tickets for <interact> 2025! (or 2 IMPRS hoodies in case of IMPRS students)๐ŸŽ‰

www.instagram.com/p/DGDSrtoo5P...

14.02.2025 12:24 ๐Ÿ‘ 3 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0