Colleen E. Clancy PhD

Khoa Ngo presented a talk on the development of an open-access, interactive web server that helps researchers interpret genetic variants by analyzing their potential impact on protein structure and function.

Check out this post: health.ucdavis.edu/precision-me...

LATEST COVER IMAGE 📸

The latest issue of JP features imagery from Guanxiao Qi and colleagues' study into transport-related effects on intrinsic and synaptic properties of human #cortical #neurons 🧠

📖 Read the issue: physoc.onlinelibrary.wiley.com/toc/14697793...

What if HFpEF isn’t just a cardiac disease?

We mined 38M+ PubMed abstracts with ML.
5,124 proteins identified.
Strong overlap with metabolic comorbidities.

Top signals? Liver & adipose tissue — not the heart.

HFpEF may be a multi-organ systemic disorder.

#HFpEF #Cardiology #AI

Natural language processing of biomedical text to map and prioritize protein–disease associations in HFpEF The validation of promising clinical biomarkers, molecular mechanisms, and novel drug targets in cardiovascular disease (CVD) is hindered by a vast an…

Check out this article: www.sciencedirect.com/science/arti...

Thermal medicine, the controlled use of heat and cold has been part of healing traditions for millennia. Now, thanks to new sensors, wearables, and AI, researchers can track individual thermal responses with unprecedented precision and turn them into personalized health insights.

December 2025 - At the Member Forum, the Physiological Society’s Editors-in-Chief including Director Colleen Clancy took the stage for an In Conversation session to share insights on research, publishing, and advancing the field together.

#Physiology #ScientificPublishing #ResearchCommunity

The Center for Precision Medicine and Data Sciences team is using supercomputing to simulate complex proteins, analyze massive omics datasets, build predictive AI models, and model synthetic heart cells to better understand disease and drug response.

hpc.ucdavis.edu/news/transfo...

October 2025 - Director Colleen Clancy shared groundbreaking work on using digital twin technology to transform cardiovascular medicine. By combining computational modeling, AI, and multimodal biomedical data, her team is building personalized virtual replicas of the human heart.

Are you attending #BPS2026 and interested in discussing your work with a JGP Editor? Stop by our booth #504 during Editor Hours ⏰️ 👇️ Our Editorial team is looking forward to chatting with you 🔬 📄 💡 💬

@ucdcpmds.bsky.social

Director Colleen E. Clancy, Ph.D., co-chaired the NIH Digital Twins in Heart, Lung, Blood, and Sleep Research Workshop, held virtually on September 25–26, 2025.

Visit: health.ucdavis.edu/precision-me... for more info!

We're incredibly excited to announce that Dr. Theanne Griffith @doctheagrif.bsky.social of #PMB Griffith Lab has been promoted to Associate Professor with tenure, effective July 1, 2026! Congratulations, Theanne, on this well-earned achievement! 🎉🌟

Her lab research: www.thegriffithresearchgroup.com

Day2️⃣ of the NRMP 5th Anniversary Highlights 🧁

@clancyatheart.bsky.social and @masi-lab.bsky.social discuss the emerging role of digital twins, combined with AI, for biomedical research that can inform preclinical decisions.

www.nature.com/articles/s43...

A new piece in @natrevmethodsprimers.nature.com from #PMB faculty member @clancyatheart.bsky.social "Towards credible digital twins for basic and preclinical research" www.nature.com/articles/s43...

Precision Medicine: What Is So Difficult? The Interplay and Complexities of Pharmaceutical and Diagnostic Partnerships to Deliver the Promise of Precision Medicine Precision medicine (PM) holds the promise of transforming healthcare through tailored treatments for an individual’s disease, improving outcomes and reducing adverse effects, by delivering the optimal...

Full text here: www.jprecisionmedicine.org/article/S305...

A new internationally author group with a deeply relevant publication highlighting key issues and challenges in precision medicine: jprecisionmedicine.org/article/S305... @jprecmed.bsky.social @jphysiol.bsky.social @physoc.bsky.social

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties Abstract figure legend Amyloid-β1-42 (Aβ1-42) triggers a male-specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway invol...

Just in time for the Holidays, our latest paper on how #amyloidbeta regulates the spatiotemporal properties of vascular L-type channels - implications for vascular function.

Great work by Jade and team! @ucdavis.bsky.social, @ucdavishealth.bsky.social

physoc.onlinelibrary.wiley.com/doi/10.1113/...

In @jgp.org, Jenna Lin and Baron Chanda compare different gating models to account for the diverse gating phenotypes observed across the cyclic nucleotide-binding domain (CNBD) family, including those arising from targeted mutations and chimeragenesis. rupress.org/jgp/article/...

#IonChannels

Stimulation of Ca2+ channel CaV1.2 activity by dopamine signaling augments spatial working memory Dopamine-induced phosphorylation of an L-type Ca2+ channel supports working memory in mice.

Great way to start the final month of the year with the publication of this collaborative work on how dopamine regulates L-type channels in #neurons.

www.science.org/doi/10.1126/...

And we got the cover!!! @ucdavis.bsky.social, @ucdavishealth.bsky.social

Congratulations!!!!!

We are anticipating a truly exceptional collection of studies based on current commitments! Please send us your study on NAMs - we would love to have a chance to review it!

📣CALL FOR PAPERS📣
For our "Contemporary antioxidant interventions: transforming the study of redox #biology in health and disease" #SpecialIssue! This special issue will provide insights into the #redox mechanisms underpinning health and disease!

🎓 buff.ly/LGKQ90r

Colleagues, we are excited to receive your papers on New Approach Methodologies! Reach out to me if you have a presubmission question!

📣 CALL FOR PAPERS📣

Examining New Approach Methodologies #NAMs in #precisionmedicine 💉🔎

Submit by 28 February 2026 ⏰

🔗 For topics and more information:

www.sciencedirect.com/special-issu...

Jehad Feras AlSamhori of The University of Jordan et al. examine the role of #ChatGPT in improving orthopedic patient education in low-resource settings across various #orthopedic specialties ✍️ 🥼

🔗 📜 Read the #Review here: www.jprecisionmedicine.org/article/S305...

In this recent #Review, Umama Shahid of Monash University Malaysia discusses the mechanistic insights, multi-omics integration, and translational horizons of #microbiome-guided precision medicine ✍️ 💉

🔗 Read the article here:
www.jprecisionmedicine.org/article/S305...

🚨CALL FOR PAPERS🚨
For our "Integrative physiological considerations of the human vasculature system" #SpecialIssue, which will showcase further insights into vascular haemodynamics and multi-organ diseases, as well as the technology used to monitor and treat cardiovascular disease

🔗 buff.ly/HN7wlPr

Photoinduced double charge accumulation in a molecular compound - Nature Chemistry The photoinduced accumulation of redox equivalents is a challenging requirement for artificial photosynthesis. Now a molecule has been developed in which the sequential absorption of photons results i...

Turning sunlight into fuel [via Uni of Basel] 🧪⚗️🪴🌞⛽🔋

"a plant-inspired molecule that can store four charges using sunlight, a key step toward artificial photosynthesis"

www.nature.com/articles/s41...

#artificial #photosynthesis #sunlight #fuel #energy #environment #friendly

Digital Twins in Heart, Lung, Blood, and Sleep Research Virtual Workshop The Digital Twins in Heart, Lung, Blood, and Sleep Research Virtual Workshop will take place virtually on September 25–26, 2025.

Please join us for the upcoming NHLBI workshop on digital twins!
Please register and spread the word! www.nhlbi.nih.gov/events/2025/...