James N. Sleigh

An image montage advertising NeuroBioUK - 11th of September 2026 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

Save the date for #NeuroBioUK26

Do you like neurons? Maybe glia? Molecules? Cell biology? - The venue is booked and we are excited to see you and your incredible science there on the 11th of September! Please do join our email list to stay up to date.

neurobiouk.sites.sheffield.ac.uk

Here, we make historic breakthroughs in Alzheimer's YouTube video by UCL Advancement

A wonderful video as part of #UCL200 - demonstrating what can be achieved when scientists work in partnership with the people impacted by disease. Carol Jennings was a phenomenal woman & that legacy continues

www.youtube.com/watch?v=L9Qo...

Looking for a review on #BDNF in neurological disease?

Dr. Aurélie Paulo-Ramos has reviewed the latest info on its role in CNS and PNS neuropathologies for you:

portlandpress.com/biochemsoctr...

@dvillarroelc.bsky.social @uclqsion.bsky.social @uclqsneuromuscular.bsky.social #neurotrophins

PhD Studentship: Genetic Modifiers to Untangle Disease Mechanisms of RFC1 Repeat Expansion at UCL Institute of Neurology jobs.ac.uk now advertising a PhD Studentship: Genetic Modifiers to Untangle Disease Mechanisms of RFC1 Repeat Expansion Visit jobs.ac.uk to apply and to browse more PhD opportunities.

A fantastic opportunity to join the team of Professor Andrea Cortese at UCL Queen Square Institute of Neurology, as a PhD student to work on genetic modifiers of RFC1 repeat expansion-associated CANVAS

The PhD is funded for 3 years, deadline 28th Feb.

www.jobs.ac.uk/job/DQK678/p...

Figure showing transport dynamics of LAMP1- and LAMP2A-positive organelles.

Reem Abouward, Giampietro Schiavo & team find that LAMP1 and LAMP2A localise to distinct axonal organelles with differential transport dynamics, but share overlapping total protein compositions.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...

Here, it will happen YouTube video by UCL Advancement

www.youtube.com/watch?v=BsSX...

Neurotrophin-containing signalling endosomes travel from the distal axon to the soma. ALS-linked kinase TBK1 governs the directionality of their transport in motor neurons by phosphorylating Rab7.
www.life-science-alliance.org/content/9/4/...

The peer reviewed and updated version of this work is now online (although not quite the fully formatted version). We had an existential crisis about kinesin-1 regulation while developing this work, but we are super proud of everything we put into this project. www.cell.com/iscience/ful...

"I might not have felt the need to step away from academia had we aimed for a lower impact journal...success isn’t solely a matter of high-impact papers...its tracing a path that isn’t defined by what others expect of me"

www.science.org/content/arti...

Learn about #axon regulation in the EMBO | The Company of Biologists Workshop "Axonal degeneration and regeneration" in Onna-son, JP, 18–22 Oct.

Abstract submission/Registration by 31 May/15 Jun

https://meetings.embo.org/event/26-axonal-degeneration
#EMBOAxonalRegeneration #EMBOevents #meeting 🧪

🧪 An EMBO Meeting on Axon Biology in Okinawa, Japan

Iconic science at an amazing venue. Please join us!

EMBO | COB Workshop on Axonal degeneration and regeneration

meetings.embo.org/event/26-axo...

My team are running the Peripheral Nerve Society's Instagram account this week: www.instagram.com/pnsociety1

If you like images of the nervous system, please check it out!

#FluorescenceFriday
@uclqsneuromuscular.bsky.social
@uclqsion.bsky.social

UCL Queen Square Institute of Neurology Hosts Neuromuscular Diseases Research Day 2025. A fantastic day bringing together clinicians, researchers and trainees to share insights and celebrate progress in NMD research. 🧠
@uclqsion.bsky.social @uclbrainscience.bsky.social
Read more: bit.ly/48N8tPI

Interview with Professor Giampietro Schiavo ABSTRACT. Giampietro Schiavo is a Professor of Cellular Neuroscience, Deputy Director for strategy at Queen Square Institute of Neurology, academic lead of the Alzheimer Research UK Drug Discovery Ins...

Didn't realize Gipi (Giampietro Schiavo) was Neuro Editor @jcellsci.bsky.social longer than I have had a lab...: journals.biologists.com/jcs/article/...

Do all #NTFs regulate #MotorNeuron axonal transport in vivo?

Our new preprint shows they do not.

#BDNF enhances (shorturl.at/siwFi), #CNTF slows, and #HGF, #NRTN & #proBDNF show no effect.

#AxonalTransport regulation is selective, not universal.

@jamessleigh.bsky.social @uclqsion.bsky.social

Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.

Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org
www.science.org/doi/10.1126/...

How much of what we think we ‘know’ is just trust in the person that told us?

And what price do we pay for confusing the two?

Coming soon in Science Without Anguish:

‘Don’t believe everything you think!’

sciencewithoutanguish.com

Starts Monday 22nd Sep

Beautiful data from @dvillarroelc.bsky.social showing a key role for TBK1 in #AxonalTransport of signalling endosomes:

www.biorxiv.org/content/10.1...

@uclqsion.bsky.social @mndassoc.bsky.social #ALS #MND

See you tomorrow - looking forward to your talk!

NeuroBioUK - Programme 9 AM Arrival, registration & coffee Session 1: Organelle and synaptic signalling Session Chair: 9:45 AM Introduction 9:50 AM Sally Horton, The Francis Crick Institute, "CDKL5 in synaptic formation,...

The programme is up for #NeuroBioUK25 - take a look! And don’t forget to register by the 3rd of September…. neurobiouk.sites.sheffield.ac.uk/programme

Thank you, Rob!

Senior Academic and Early Career Promotions 2024-25 Huge congratulations to the UCL Queen Square Institute of Neurology staff who have been awarded a promotion in this year's promotions round.

It's an honour to become a Professor at such a wonderful institution @uclqsion.bsky.social @uclbrainscience.bsky.social. The @uclqsneuromuscular.bsky.social is an amazing place to work and I couldn't have done it without my fantastic team, mentors and collaborators:

www.ucl.ac.uk/brain-scienc...

The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis Nature Communications - Neuromuscular junctions (NMJs) are denervated in amyotrophic lateral sclerosis (ALS) through unknown mechanisms. Here, the authors show immune cells infiltrating muscle of...

🚨 New #ALS #MND publication from our lab (co-lead @drchayts.bsky.social), in collaboration with Bernát Nógrádi and colleagues from Hungary and Sonia Alonso-Martin and colleagues from Spain, just published in @natcomms.nature.com -> rdcu.be/eyNIs

Next UCL ALS-FTD Network Seminars - 25 July at 4pm, Gilliatt LT, QSH.

'Investigating pathomechanisms in Charcot-Marie-Tooth disease using mouse models and iPSCs'

'Generation of a universal human cellular platform for drug testing in ALS'

'A forebrain organoid model of progranulin-associated FTD'

Microtubule curling as an efficient readout to uncover fundamental concepts of axonal

doi.org/10.1101/2025...

LEAF Award 2025

Delighted that the department has been awarded Gold for Laboratory Efficiency Assessment Framework (LEAF) 2025. We were commended on the labs signage, management and sustainable initiatives across the whole department.

I’m super happy for you Gita - thoroughly well deserved!

#ResearchResources:
Lots of great free resources for researchers & research students. Thesis planners, goal setting tools, agendas, To-Do lists. Completely customisible and free. No login, no catches. Just download & use. From: buff.ly/2L0YISj #PhDchat #ECRchat #postdoc

We welcome Volume 247 with this fantastic image from work by Sosa et al. This study provides the first comprehensive description of the hindlimb musculature of the #Emperor #Penguin (Aptenodytes forsteri) across different ontogenetic stages. doi.org/10.1111/joa....

Very excited to share our latest preprint! We looked at loss and gain of function, innervation, reinnervation, and in vivo axonal transport in a FUS-ALS mouse model!

www.biorxiv.org/content/10.1...

@uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social