Very happy to see this out! Great work by @lockwop.bsky.social @crick.ac.uk and first paper on NTMs from the lab! Parise made a set of 12 fluorescently labelled NTMs covering environmental and opportunistic mycobacteria...
onlinelibrary.wiley.com/doi/10.1111/...
Iโm pleased ๐ค to share our new preprint exploring the mode of action and resistance of the antitubercular drug pyrazinamide (PZA) ๐ Thanks to everyone who have participated ๐
We hope these findings will help the fight against drug resistance in tuberculosis.
www.biorxiv.org/content/10.6...
#OnThisDay in 1938, American evolutionary biologist Lynn Margulis was born. Margulis is most known for developing and popularising the endosymbiotic theory, which explains how eukaryotic cells evolved organelles from simpler prokaryotic organisms that resided within another and became incorporated.
The #BirdOfTheDay theme today is #SideView
The elusive jay.
#photography #photographic #photographers #Birds #Wildlife #Ireland
#blueskybirds
#birdsofbluesky #nature
#EastCoastKin
The human right to a healthy, clean & sustainable environment could be a game changer for tackling #AMR's environmental drivers. But how could this work? Wendy Boucrot, Sheila Varadan & I review how the new right could be applied to #antimicrobial pollution.
doi.org/10.1017/pub....
#STS #HistMed
I'll swim the seas inside with you
And like the waves, without a sound
I'll never let you down
#Ireland #Mayo #WildAtlanticWay
#photography #photographie #photographers
#EastCoastKin
On #RareDiseaseDay, we recognise the leadership of Dr Cormac McCarthy, whose voice continues to raise research impact & awareness of Lymphangioleiomyomatosis (LAM). . #clinicaltrials
Patient partnership drives progress.
@ucdmedicine.bsky.social @ucddublin.bsky.social
Unrooted phylogeny indicating the major clades of Mycobacterium bovis found in Ireland.
The genomic diversity and spatial patterns of Mycobacterium bovis in Ireland revealed by whole genome sequencing rdcu.be/e50zT
Recovering Mycobacterium tuberculosis ๐ฆ from ancient samples is notoriously difficult. But, in this new study, the elusive M. tuberculosis DNA was detected in five individuals from medieval Ireland.
doi.org/10.1016/j.tu...
#MetagenomicsMonday #SPAAM #aDNA #paleogenomics #tuberculosis #TB #pathogen
Can safely way this is the craziest and coolest study I have led. We chart the evolution of sheeppox virus, finding it in the Eurasian steppe ~3700 years ago, and also in a LOT of parchment from medieval Europe (made from a range of animals skins!) #aDNA
Great work by Jamie Gorzynski and Josh-Harling-Lee from the group providing insights into the evolutionary origins of bacterial lineages. A collaboration with @jrpenades.bsky.social @wfigueroac3.bsky.social. #Staph Cell Reports www.cell.com/cell-reports...
Beautiful and solid work on trehalose monomycolate synthesis in mycobacteria by @figlegend.bsky.social lab. Check it out folks. Also, for the non-enzymologists, product inhibition is a thing, and actually does matter. ๐
www.pnas.org/doi/10.1073/...
Myeloid core of TB granulomas is partitioned into two distinct metabolic environments, one of which is hypoxic & associated with pathological immune cell states that subvert immunity to TB @natimmunol.nature.com @erin-mccaffrey.bsky.social
www.nature.com/articles/s41...
Good god Ireland are great
Insights into how #Staph aureus adapts to the bovine host by unlocking nutrients from the dairy niche. Great work by Amy Pickering, Jamie Gorzynski and others in the group. Bacterial metabolic remodeling by convergent evolution after a host switch.|Science Advances www.science.org/doi/10.1126/...
In the largest study of its kind, scientists in the Bork Group at EMBL have found that a small subset of microbes can carry and transfer genes across disparate habitats, creating a planet-wide, interconnected network of microbiomes ๐ ๐ฆ
๐ Read more here: www.embl.org/news/science...
Congrats to @aschwalbc.bsky.social for bringing this work to the finish line!
Weโre excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
low winter sun
#EastCoastKin
#photography #photographie #photographers
#Ireland
๐ฌ Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
๐
Deadline: Feb 9, 2026
๐ฅ 2-12 years post-PhD
Apply now ๐ research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Of course I like all the papers that we publish, but this is actually a very cool story, a great example of 'bush mechanics' in mycobacteria.
A new role for lipoproteins LpqZ and FecB in orchestrating mycobacterial cell envelope biogenesis | mBio journals.asm.org/doi/10.1128/...
Really pleased to share the first paper to come out of the lab.
We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung.
The phylogenies indicate that the clones moved from lung->gut
www.nature.com/articles/s41...
What are the associations between #AMR ๐ & #climatechange ๐ฆ๏ธ?
In Nature Climate Change, we evaluate existing evidence & define a challenge-oriented research agenda to uncover best equitable practice for synergistic governance responses:
doi.org/10.1038/s415...
@cermes3.bsky.social
On the last day of #WAAW ๐ ๐, some historians gave to me โฆ
...a major review of the political-economic factors & concepts shaping #antimicrobial innovation since 1980 - and a call to diversify #antibiotic #R&D moving forward!
www.cambridge.org/core/journal...
For a summary, see the thread (1/9)
Congratulations Jay! Fantastic
Figure showing the immunopathogenesis of Shigella infection in the colon. MAMPs=microbe-associated molecular patterns. DAMPs=damage-associated molecular patterns. NK=natural killer. Adapted from Schnupf and Sansonetti. Copyright: 2025 Elsevier Ltd. All rights are reserved.
Shigellosis is the most common cause of invasive bloody diarrhoea in children younger than 5 years.
The prevention of infection with vaccination & sanitation strategies remains a crucial step in reducing worldwide morbidity & mortality.
Find out more โถ๏ธ tinyurl.com/ard69t83
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
Harvest Time: The UCD Rosemount Orchard has rolled out a carpet of apples ๐
Excited to share Wendy Le Mouรซllicโs PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cellsโfueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Revisited model of PZA/HPOA efficacy, supporting a pH-dependent mechanism of weak acid permeation and cytosolic acidification as main mechanism of bactericidal activity. In this model, the authors propose that the presence of glycerol potentiates PZA/HPOA efficacy by generating acidic intermediates that lower IBpH. Accordingly, ฮฒ-alanine and pantothenate might mitigate this effect by acting as buffering molecules that alleviate acidosis. Finally, PanD enzymatic activity consumes protons which in turn increases IBpH. Therefore, in this model PanD minimally contributes to PZA tolerance and cannot be considered as the primary target of the drug.
New study shows pyrazinamide kills TB by acidifying bacterial cytosol โ not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky
โ๏ธ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
๐ shorturl.at/tuz6Q
