Not something you see in textbooks very often: tripolar mitosis.

Advancing regulatory variant effect prediction with AlphaGenome - Nature AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...

Surprised (but also not that surprised) that the AlphaGenome paper didn't officially cite any of the primary data used for training their model (see Fig. 1, thousands of datasets made with tremendous time and effort over >15yrs). What's up with that @nature.com ?

www.nature.com/articles/s41...

Check out our new work now published in G3! We use proteomics and phosphoproteomics to study how cells cope with tRNA variants that mis-insert amino acids.

They want to tell you a kid with a Spider-Man backpack is evil Liam Ramos' innocence, like the innocence of all kids, is unimpeachable. The visuals of his arrest are excruciating.

Something is deeply wrong if we, as a society, cannot agree that an administration that snatches up children, uses them as bait to hunt down others, is morally repulsive.

Rejecting Decades of Science, Vaccine Panel Chair Says Polio and Other Shots Should Be Optional

This is a death sentence for America.

www.nytimes.com/2026/01/23/h...

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.

Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!

www.nature.com/articles/s41...

This article seems pretty relevant to me.

utstat.utoronto.ca/reid/sta2201...

James Watson, dead at 97, was a scientific legend and a pariah among his peers James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.

The definitive obituary of James Watson, written by the late, great Sharon Begley @statnews.com www.statnews.com/2025/11/07/j...

Carafe enables high quality in silico spectral library generation for data-independent acquisition proteomics - Nature Communications Accurate spectral libraries are essential for analyzing data-independent acquisition (DIA) proteomics data. Here, the authors present Carafe, which trains on DIA data to build experiment-specific spec...

Fantastic project led by @bo-wen.bsky.social. Excited to see the future uses of AI and transfer learning in proteomics. #massspec #proteomics
www.nature.com/articles/s41...

This really hasn’t gotten enough attention this week.

@wired.com #ICE
www.wired.com/story/fbi-wa...

Seattle Spent Millions on Hotel Rooms to Shelter Unhoused People. Then It Stopped Filling Them. Early last year, the city signed a $2.7 million lease extension to continue using a hotel’s rooms as shelter space. Yet despite committing to pay the rent, the city stopped sending people there.

NEW: After paying for hotel rooms to shelter homeless people, Seattle deliberately left them vacant.

By the end of 2024, taxpayers were spending $4,200 a month per empty room at a time when thousands of residents were without a roof over their heads.

Note that the Trump Administration is already going back to schools with whom it earlier reached "deals" (such as UPenn and Brown) for further concessions. Conceding to a bully has only emboldened them to make new demands.

Schlittler strikes out 12 in postseason debut as Yankees beat Red Sox 4-0 to win Wild Card Series Rookie right-hander Cam Schlittler struck out 12 as he shut down Boston with 100 mph heat, and the New York Yankees took advantage of a pair misplays in a four-run fourth inning to beat the Red Sox 4-0 for a 2-1 AL Wild Card Series win and a Division Series matchup against Toronto.

The New York Yankees beat the Boston Red Sox in Wild Card Series to advance to the AL Division Series against the Toronto Blue Jays.

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...

How Stowers Scientists Found the DNA Site Where Robertsonian Chromosomes Fuse YouTube video by Stowers Institute for Medical Research

🚂 The T2T train keeps rolling: "The formation and propagation of human Robertsonian chromosomes" with Gerton and Garrison labs is out! What's a Robertsonian chromosome? Let Jen tell you herself in this great video, or read our paper: [1/3]
📺 youtu.be/JmlY5omxQVc
📄 www.nature.com/articles/s41...

America’s elite colleges are perpetual inequality machines. It doesn't have to be this way. Rather than steer the nation's top students toward the most lucrative careers, schools could help them build meaningful lives.

Elite colleges are infamous for funneling students into the Big Three—consulting, tech, and finance—high-paying fields that perpetuate status and wealth.

To some young people, it feels like entrapment: “They get you before you could be exposed to other jobs.”

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

A Trailblazing Geneticist Reflects On Her Life And Work Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.

Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.

Real-time API control of mass specs has been hard to get started (C#, VS, etc). Mike Hoopmann's recent work makes dev easier & more open!:

Nova - lightweight dev library
schweppelab.github.io/Nova/ pubs.acs.org/doi/full/10....

Helios - a unified instrument API now @ JPR
github.com/SchweppeLab/...

(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!

Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵