Sophie Bonnal

Wonderful read on microexons — their regulation, cross-species functions, disease relevance & therapeutic potential.

Thanks to all co-authors and to everyone who supported this work - check it out!

Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4 Nature Structural & Molecular Biology, Published online: 07 August 2025; doi:10.1038/s41594-025-01634-1Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode microexon sensitivity to SRRM3 and SRRM4. This work revises the switch-like splicing regulation model into a dose-responsive continuum.

New online: Core splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function - Nature Biotechnology RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.

A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function go.nature.com/4mc1SmQ

🐁 A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation.