Golnaz Vahedi

Join @pennepigenetics.bsky.social on 2/23 for their 2026 symposium ft'ing Scott Armstrong, Ali Shilatifard, Ting Wang, @weissmanlab.bsky.social, Huda Zoghbi, @gburslem.bsky.social, Erica Korb, Mitchell Lazar, @vahedilab.bsky.social & Zhoalan Zhou. Learn more & register➡️ tinyurl.com/3zdms2yx

Didn’t get the grad school interview you wanted yet? Turn this year into a launchpad. The Vahedi Lab @Penn is hiring a Research Specialist A/B — an ideal role for undergrads & recent grads aiming for PhD/MD-PhD programs.
🧬 Immunology + genomics. Apply here: lnkd.in/e8uT_hif

I3H Deputy Director, Dr. Vahedi (@vahedilab.bsky.social) will be discussing "Multiome Profiling in Human Type 1 Diabetes" at this month's session of the Colton Consortium Virtual Speaker Series (Jan. 20, 11:00am ET). Register to secure your spot: bit.ly/VahediJan20

ft. @yeqiaoz.bsky.social, N. Burget, Tobias Friedrich, @faryabi.bsky.social (@pennpathlabmed.bsky.social), @atishayjay.bsky.social (Bioeng), S. Yoon & @vahedilab.bsky.social (@penngenetics.bsky.social) @pennepigenetics.bsky.social @i3h-upenn.bsky.social www.nature.com/articles/s41...

ft. M. Abedi, P. Rai, Y. Zhou, C. Liu, I. Johnson, A. Chandra, M. Fasolino, S. Rostami, W. Wang, Z. Min, Y. Li, M. Yu, @atishayjay.bsky.social, V. Lian, M. Silverman, @kkaestner.bsky.social, A. Naji, B. Faryabi & @vahedilab.bsky.social @penngenetics.bsky.social www.science.org/doi/10.1126/...

OLIVE provides rapid visualization and analysis of chromatin tracing experiments Zhou et al. develop the optical looping interactive viewing engine (OLIVE), a web-based application for browsing and exploring user-generated and publicly available chromatin tracing datasets.

Three new manuscripts from Faryabi and Vahedi labs on chromatin folding, ORCA, oncogene regulation and T1D immunology. Individually great, collectively unstoppable. @faryabi.bsky.social @vahedilab.bsky.social @atishayjay.bsky.social

tinyurl.com/4nwfbeu2
tinyurl.com/4zaw5cn7
tinyurl.com/25snbf4j

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...

Kudos to Yeqiao Zhou, @atishayjay.bsky.social, and @vahedilab.bsky.social for our new @natcellbio.nature.com study www.nature.com/articles/s41...! By integrating chromatin tracing and polymer modeling, we revealed how lineage-determining TFs shape folding of B-cell lymphoma and T-ALL genomes.

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation - Nature Cell Biology Zhou, Jay et al. report that in mantle cell lymphoma and T cell leukaemia, lineage-determining transcription factors share a mechanism to regulate how multiple enhancers control oncogene expression th...

Beyond excited to share the collaborative work with @faryabi.bsky.social led by stars Yeqiao Zhou and @atishayjay.bsky.social; Walking along thousands of chromosomes has shown us just how essential it is to measure chromatin fiber geometry to truly understand enhancer biology. tinyurl.com/2st3afwf

With co-first author, CAMB Alum, Yeqiao Zhou from her time in the Faryabi Lab (@faryabi.bsky.social)

Wow, beautiful, Congrats!

Rapid compensatory evolution within a multiprotein complex preserves telomere integrity Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...

We are also beyond grateful to @sciimmunology.bsky.social editorial team and also the peer review process helping us improve the quality of our study

The pancreas and lymph node tissues generously were donated by deceased organ donors and their families. This work was a major collaboration between Maryam Abedi, Priyadarshini Rai (Vahedi lab) and Yeqiao Zhou (Faryabi lab) and the @thehpap.bsky.social team

We discovered a distinct subset of CD4 T cells present only in the PLNs of donors representing active-disease stage. These “rogue” T cells showed elevated activity of the transcription factors NFKB1 and BACH2 along with widespread chromatin remodeling associated with those regulators.

Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.

I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ

Congratulations to @ksusztak.bsky.social (@pennmedicine.bsky.social/ @penngenetics.bsky.social/ @chopresearch.bsky.social) on her election to the National Academy of Medicine! Learn more about Dr. Susztak & her research here➡️ www.med.upenn.edu/susztaklab/ #PSOMatNAM @nam.edu

Congratulations to Gerd Blobel (@chopresearch.bsky.social/ @pennmedicine.bsky.social/ @pennepigenetics.bsky.social) on his election to the National Academy of Medicine! Learn more about Dr. Blobel & his research here➡️ blobellab.squarespace.com #PSOMatNAM @nam.edu

Artificial intelligence in metabolic research - Nature Metabolism The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.

In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: www.nature.com/articles/s42...

Congrats!

Thrilled to share my promotion to Associate Professor with tenure at @pitt-immunology.bsky.social! Huge thanks to my incredible lab, collaborators, department, colleagues, family & friends. Science is a team effort, and I'm so proud of our work & excited for what's next! Stay tuned!

Congrats!

Research Specialist A/B University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...

The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...

Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...

Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...

Excellent news!

New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers. If you work with these data, give a try: www.biorxiv.org/content/10.1...

If you are interested in T and B cells, you can look your favorite gene and its connectivity here: sorayoon.shinyapps.io/HiCociety/

Hi-Cociety does magic: it takes Hi-C data and determines cell-type specific highly connected regions without taking any additional input.

🚨 New #preprint alert!
We're excited to share the latest work from the brilliant Sora Yoon: "Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety"🔗 www.biorxiv.org/content/10.1...

🚨 New #preprint alert!
We're excited to share our latest work:
"Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

Deep gratitude to the Vahedi and Faryabi Labs and all our supporters and funders who made this possible! #Tcells #chromatin #generegulation #microscopy #epigenetics #immunology #developmentalbiology #ORCA #teamwork