David Corcoran

Maximising imaging volumes of expanded tissues for inverted fluorescence microscopy https://www.biorxiv.org/content/10.1101/2025.09.12.675899v1

I think expansion only "clears" the sample because it dilutes it. E.g. 4x expansion is 4x4x4=64 times dilution. I'm guessing the proteases/heat used in expansion don't contribute much, if at all, to clearing.

Expansion microscopy is sort of like a clearing technique. Also ideal for lightsheets with water dipping objectives as the expanded sample ends up with a similar refractive index to water.

A fun and creative way to learn about someone's work

Outcome-Driven Microscopy: Closed-Loop Optogenetic Control of Cell Biology Smart microscopy is transforming biological imaging by integrating real-time analysis with adaptive acquisition to enhance imaging efficiency. Whereas many emerging implementations are event-driven an...

From the Kapitein lab:
www.biorxiv.org/content/10.1...

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We are building a quantitative imaging team at Warwick!
Join an interdisciplinary endeavor with Mishima, Balasubramanian, and Mayor labs on a @wellcometrust.bsky.social funded project to push probe and microscopy development!

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Only very distantly, I guess!