Graphical abstract from our new paper in Nucleic Acids Research with @saramaciasrna.bsky.social 🧬
DGCR8 prevents accumulation of endogenous dsRNA derived from Alu elements within mRNAs, avoiding aberrant activation of the interferon response.
academic.oup.com/nar/article/...
¿Quieres descifrar los mecanismos epigenéticos del rejuvenecimiento celular? Si tienes un expediente académico superior a 8.5 y buscas realizar tu tesis doctoral en un entorno de excelencia (GENYO, Granada), contáctanos para solicitar becas FPU/Junta. Deadline inminente! ⏩
"Freezing forgetting in C. elegans to extend memory retention" - check out the "research briefing" about our new paper in Nature Neuro
rdcu.be/eYlXY
New Year, New Paper!🎊
Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system
www.biorxiv.org/content/10.6...
Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵
Congratulations Rob and team. Elegant! As usual! 👌🔝
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
OFERTA DE EMPLEO (por favor difundir):
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
NIH Director Jay Bhattacharya has struggled to convince observers he has the agency’s best interests in mind—and is truly in charge. https://scim.ag/3MMXDSh
Congrats to @allanaschooley.bsky.social et al. @jobdekker.bsky.social on this beautiful paper, using a very elegant experimental system, to discover a chromosome intrinsic 3D genome folding program and microcompartmentalization of CREs at mitotic exit:
🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜
www.science.org/doi/epdf/10....
Be sure to also check out the great paper from @andersshansen.bsky.social and colleagues where they discover microcompartments on mitotic chromosomes using Region Capture Micro-C. Exciting times for those interested in chromosome conformation during cell division!
www.nature.com/articles/s41...
Ponencia de Ángel Carracedo en las XIII Jornadas científicas de Genyo.
📖 El 24 de noviembre de 1859 se publicó #ElOrigenDeLasEspecies de #Darwin donde se establece su teoría de la #Evolución por #SelecciónNatural
🧬 Una de las obras científicas que más impacto ha tenido en todo el mundo occidental.
#díamundialdelaevolución
Origins of chromosome instability unveiled by coupled imaging and genomics @nature.com
www.nature.com/articles/s41...
There is one point of agreement among both enthusiasts and sceptics: the future has already arrived
go.nature.com/48M5Xuu
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Y aquí tenéis la noticia en vídeo con entrevista a @davidlandeira.bsky.social en @canalsurradiotv.bsky.social (sí, parece que ha salido en un programa infantil; despertando vocaciones ☺️). labanda.canalsur.es/noticias/and...
Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...
When and how do we start aging? Our recent work, led by Amador Gallardo, suggests that aberrant expression of ancient viral remnants in our genome—already during embryonic development—may induce aging in adults. 😮https://www.nature.com/articles/s41467-025-63778-4.pdf
🔴 ¡Acaba de publicarse en Nature Communications (@natcomms.nature.com)! 🎉 Feliz de haber contribuido a este increíble trabajo del grupo de David Landeira (@davidlandeira.bsky.social), con Amador Gallardo como primer autor. (1/2)
Ahi va la nota redactada por nuestro equipo de divulgación sobre nuestro ultimo trabajo! canal.ugr.es/noticia/enve...
“From a different angle, our study also supports that BMAL1 regulates the transition from the totipotent to the pluripotent state during early development, by facilitating MERVL transposon repression and the downstream 3D organization and function of the genome.”
Building on a previous report from the Fitzgerald lab showing that loss of Bmal1 during embryogenesis accelerates aging in adulthood, our findings support the idea that preserving the epigenome during embryogenesis is crucial to slow the pace of aging later in life.
Huge thanks to collaborating labs Bellora, Estevez, @herassr.bsky.social @mamartirenom.bsky.social @waltzingpiglet.bsky.social and @canalugr.bsky.social
Thrilled to share our story in its final form! nature.com/articles/s41... 💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
