Spakowitz Lab

Influence of dipolar solvent fluctuations on polyelectrolyte thermodynamics and complex coacervation We present a self-consistent polyelectrolyte field theory that reveals the impact of solvent polarity and polymer semiflexibility on polyelectrolyte solution th

Our paper in JCP utilizes polymer field theory to explore the impact of solvent correlation and dielectric inhomogeneity on polyelectrolyte phase behavior. My student, Michael, did an outstanding job in addressing this fundamental problem in polymer science.
pubs.aip.org/aip/jcp/arti...

Physical models reveal indirect reader protein interactions that facilitate epigenetic crosstalk | PNAS The spatial organization of chromatin is governed by epigenetic factors, including epigenetic marks and the reader proteins that bind them. By dict...

Our recent manuscript “Physical models reveal indirect reader protein interactions that facilitate epigenetic crosstalk” was published in PNAS. Joe Wakim used simulations and machine learning to reveal mechanisms for programming and reprogramming of cell behavior.

www.pnas.org/doi/10.1073/...

Leveraging inhomogeneous binding of incompatible constituents for adaptive copolymer self-assembly Using a polymer field-theoretic model, we present a system containing copolymers and two distinct chemical moieties that bind heterogeneously along the copolymer chains, enabling self-assembly of a ra...

Thomas Habte and I recently published “Leveraging inhomogeneous binding of incompatible constituents for adaptive copolymer self-assembly” in Soft Matter, predicting a new co-polymer material that can access a range of stable phases without changing polymer sequence.

pubs.rsc.org/en/content/a...

The Spakowitz Lab at Stanford (Theory and Computation of Biological Processes and Soft Materials) is delighted to join the Bluesky community! We look forward to sharing our work and to learning about your research achievements.