Nancy Santiappillai

Late to post, but so greatful to have presented my talk on prostate cancer metabolism at the @ismrm.bsky.social workshop on Metabolomics and Metabolomic Imaging in Medicine in Padua, Italy! And to be awarded Top Abstract!

reactant and product metabolite ratios revealed metabolic pathways differences between cancer subtypes and noncancer cell lines by @hoylipidlab.bsky.social @sydneyprecisionds.bsky.social @nancyts.bsky.social ➡️ www.embopress.org/doi/full/10....

Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells | Molecular Systems Biology imageimagePathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective standard conditions reveals common and distinctive metabolic signatur...

Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10....
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.

Had a great time sharing our work on macrophage TNBC symbiosis at the NYAS Cancer and Metabolism symposium!

Sweet success in CAR T cells - Nature Reviews Cancer Glycolysis-dependent T cell function is hindered by glucose scarcity in the tumour microenvironment. Now in Cancer Cell, Schild et al. engineered T cells to utilize fructose via GLUT5, enhancing their metabolic activity and cytotoxicity.

In @cp-cancercell.bsky.social, Schild et al. @mskcancercenter.bsky.social engineered T cells & CAR T cells to express the fructose-specific transporter GLUT5, improving T cell glycolytic flux & thus effector function in glucose-limited conditions.
📖 the #researchhighlight 👇