Harry Wilders

Check out our new paper in @commschem.bsky.social, where we identified a novel enantioselective fragment for the deubiquitinating enzyme, OTUD7B. An absolute pleasure to co-lead this project with Aini Vuorinen and @cassandrakennedy.bsky.social!

www.nature.com/articles/s42...

Excited to see this out in Nature Communications. A great platform to profile reactive fragments against the human proteome (and beyond), quickly and accurately.

#ChemBio #Chemsky

Probing covalent mechanisms of regulation and inhibition in mitotic kinases at University of Leeds on FindAPhD.com PhD Project - Probing covalent mechanisms of regulation and inhibition in mitotic kinases at University of Leeds, listed on FindAPhD.com

Interested in a PhD combining high-throughput synthesis, structural and cell biology to understand kinases? Deadline to apply for a project with Richard Bayliss, Helen Matthews and me: January 6th! www.findaphd.com/phds/project...

#chembio #chemsky

Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening Direct-to-biology workflows promise to accelerate hit optimisation for drug discovery. Here, we describe a direct-to-biology method for the efficient synthesis and screening of cysteine-reactive frag...

I am happy to share that our recent work has been published in Angewandte Chemie.

We demonstrate how ‘direct-to-biology’ screening can accelerate optimisation campaigns, yielding potent covalent and non-covalent inhibitors from reactive fragment hits.

onlinelibrary.wiley.com/doi/full/10....

ChemBio fans please repost the #ChemicalBiology Feed bsky.app/profile/thor...

@carolynbertozzi.bsky.social @ritastrack.bsky.social @stephanhacker2.bsky.social @stuartcantrill.bsky.social @laurahowes.bsky.social @dirktrauner.bsky.social @chemjobber.bsky.social @dereklowe.bsky.social

#chemsky