Now let’s generate the data to deliver personalized, science-backed care for women’s health. Especially vascular-brain health 🧠🫀
www.bloomberg.com/news/videos/...
@sinaibrain.bsky.social
Hormone replacement therapy (HRT) is not dangerous. Timing and formulation are critical components of benefit vs. harm. I’m glad to see the FDA warnings removed from HRT.
Thanks @bloomberg.com for covering this important topic: www.bloomberg.com/news/videos/...
Can biology, lifestyle & technology redefine ageing? At @mountsinainyc.bsky.social, a multidisciplinary team, led by Miriam Merad, Zahi Fayad and Fanny Elahi, is working to understand and intervene in biological processes that drive ageing. @natureportfolio.nature.com www.nature.com/articles/d42...
Such a pleasure to speak with @beingpatient.bsky.social about Alzheimer’s Disease risk in women 🧠
Hint: it may in large part hinge on vascular health!
beingpatient.com/why-women-fa...
Postdoctoral fellow @chloelopezlee.bsky.social published a co-first-author paper in Immunity on the protective effects of the Christchurch mutation (R136S) against tauopathy. Read more about their powerful findings below 👇
pubmed.ncbi.nlm.nih.gov/40555238/
Jonah, an associate researcher with our lab, has been selected as a Samvid Scholar to support his MD graduate studies. Jonah is an exceptional trainee, and we're incredibly proud of this well-deserved recognition.
samvidscholars.org/team/jonah-k...
Incredible week for the Elahi lab!
Jonah Keller was selected as a Samvid Scholar and @chloelopezlee.bsky.social published her co-first author paper in Immunity! So proud of this team 🧠
Read more about both rising stars below 👇
Honored to be part of this amazing team! Excited for what’s ahead!
Delighted that blood biomarkers are getting added to clinical workflows—this is game changing and this is just the start!! Thanks to all our partners on this 🌎 an amazing multi-disciplinary global village
On Fri, May 9th, 2pm, DON'T MISS this #FriedmanBrainInstitute Special Seminar as hosts @ericjnestler.bsky.social & @fanny-elahi.bsky.social welcome @institutducerveau.bsky.social's Dr. Stéphanie Debette 👉 (Gen)omics of cerebral small vessel disease: implications for brain health across the lifespan.
📣This #InternationalWomensDay I'm spotlighting a women’s brain health initiative led by our lab, with postdocs Chloe Lopez Lee & Eirini Polychronaki @sinaibrain.bsky.social
We're working to understand how hormonal shifts in menopause influence blood vessels, brain aging, & dementia 🧠 #IWD2025
Excited to share my joint first-author paper (with @rachiscahill.bsky.social) published today in Nature Medicine (@natmedicine.bsky.social, @nature.com). Our findings are timely as the #HD therapeutic landscape expands toward preventive clinical trials. 🔓 Open access: www.nature.com/articles/s41...
Did your child lose their book collection in the Los Angeles fires? Are you a teacher at a school that lost its library or your classroom library? Whether you need one book or a whole library, we can replace your books. 📚
Everyone else, please boost this post so we can connect with those in need. 🙏
Huge congrats to the very talented co-first authors Abel Torres-Espin and Hannah Radabaugh. Special thanks also to Adam Ferguson, Joel Kramer, Jason Hinman, Kaitlin Casaletto, Charles DeCarli, Bruce Miller, and all co-authors working at @sinaibrain.bsky.social, @ucsfmac.bsky.social and beyond! (7/7)
Studying sex as a biological variable is essential to advancing understanding of brain aging and dementia-causing diseases with important implications for therapeutic efforts.
We are now actively working on unpacking underlying mechanisms to identify therapeutic targets (6/7)
🔑 Key takeaway: dysregulations in vascular plasticity and the factors related to this process may impact brain vulnerability to injury and degeneration with important differences between women and men. (5/7)
Higher measures of aberrant angiogenesis were associated with lower gray matter volumes, higher white matter injury, and worse cognition. Notably, we uncovered distinct patterns in women and men! With a flip 🔁 in directionality in the 70s (4/7)
We used ML on blood measures 🩸 of angiogenic factors and derived a measure that we named (1) Aberrant angiogenesis and another (2) Vascular health, reflecting the directionality of associations with brain structure and function. (3/7)
Unpack the biology: our new paper in @ScienceTM asked whether there may be sex-dimorphic differences in vascular brain aging and what this would mean for cognitive aging. (2/7)
🧠 Women are twice as likely to develop Alzheimer’s disease. Many factors may contribute. Our lab is focused on understanding contributions from vasculature!
www.science.org/stoken/autho...
(1/7)
Really enjoyed Julie @siegenthalerlab.bsky.social ‘s talk! Beautiful work and fantastic delivery. She’s also an awesome person!
We are looking for computational scientists with experience using multi-omics data. Neuroscience experience is a plus but not required. All levels welcome to apply. DM me if interested! #VCID #EndDementia @sinaibrain.bsky.social
Thanks to FOX24News for having me on to spotlight #CADASIL. I hope this gives insight into this disease and highlights why we believe targeting blood vessels is key to developing effective treatments #VCID #EndDementia.
More info below 👇
www.elahilab.com/
