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Parker Singleton

@parkersingleton

Senior Scientist at Penn Lifespan Informatics and Neuroimaging Center (PennLINC) studying psychedelics and the brain. sypres.io

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10.10.2023
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Latest posts by Parker Singleton @parkersingleton

🧠 Resting-state fMRI is often treated as the gold standard for studying the brain’s intrinsic organization.

But is it actually the best way to estimate functional architecture?

We tested this directly.

🧡1/8

10.03.2026 19:19 πŸ‘ 121 πŸ” 54 πŸ’¬ 4 πŸ“Œ 11
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We think of white matter as the highways of the brain. But when we followed development along those highways, we were surprised. The journey is more complex than we thought. My final PhD paper, β€œTwo Axes of White Matter Development”, is now out in @natcomms.nature.com! πŸ›£οΈπŸ§ βœ¨
πŸ”— bit.ly/wm2axes

02.03.2026 01:09 πŸ‘ 103 πŸ” 47 πŸ’¬ 2 πŸ“Œ 4
Africa - Angel City Chorale
Africa - Angel City Chorale YouTube video by Angel City Chorale

Every participant had a MEQ-30 score of 150: youtu.be/-c9-poC5HGw?...

05.02.2026 15:27 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

My first preprint is out! Thank you to my brilliant collaborators & mentors for making this possible @vmarchman.bsky.social @arokem.org @jyeatman.bsky.social, as well as everyone behind the awesome open source software that we use @pennlinc.bsky.social @cieslakmatt.bsky.social (& many not on bsky)

25.01.2026 03:33 πŸ‘ 7 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0

My Neighbour Totoro is I think the only movie I can think of that has a compelling plot for kids that does not involve a villain.

05.01.2026 20:39 πŸ‘ 11 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

hahahah

05.01.2026 22:16 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Physiological Arousal as a Predominant Source of Individual Differences in Functional Brain Networks Individual differences in brain network function and organization are promising targets for fMRI-based biomarkers in precision psychiatry, yet the sources of individual variability remain poorly under...

Another important one for psychedelics fMRI ppl: www.biorxiv.org/content/10.6...

05.01.2026 20:28 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Come join an amazing team where you're guaranteed to set yourself up for future success!

24.11.2025 22:13 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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πŸ’Š 🍸 Risk for substance use disorder (SUD) rises in adolescence. Family history and biological sex play major roles in a person's level of SUD risk. New evidence suggests neural markers of SUD may exist before substance use starts - yet how these markers differ across sexes is not understood.

21.11.2025 16:38 πŸ‘ 5 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0
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🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧡funded by NIMH R01MH113550
www.biorxiv.org/content/10.1...

12.11.2025 21:53 πŸ‘ 38 πŸ” 18 πŸ’¬ 1 πŸ“Œ 3
Preview
Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications The landmark ongoing HEALthy Brain and Cognitive Development (HBCD) study will longitudinally chart brain development in a large sample (projected n=7,200) of infants through age 10 years with multimo...

After years of development and testing, we are happy to present our work in "Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications"! www.biorxiv.org/content/10.1.... A thread:

11.11.2025 22:03 πŸ‘ 44 πŸ” 28 πŸ’¬ 3 πŸ“Œ 2

Strongest data yet suggesting that repeated MDMA use causes deficits in declarative memory (e.g., memory for new information, words, etc). #psychedelicscience #MDMA

10.1093/brain/awaf391

27.10.2025 03:33 πŸ‘ 16 πŸ” 8 πŸ’¬ 2 πŸ“Œ 0

I thought about busting the PS out of the attic recently just for Spyro and Crash Bandicoot

20.10.2025 19:44 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Hot off the press!

20.10.2025 19:42 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
πŸ‘‡πŸ§΅

nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging

15.10.2025 20:18 πŸ‘ 47 πŸ” 24 πŸ’¬ 1 πŸ“Œ 3

If you agree to review a paper, you should send it in on time. You're holding a spot and slowing up the whole process if you don't.

14.10.2025 15:32 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I just saw someone use the abbreviation β€œAI;DR” and I’ll be laughing for a while.

06.10.2025 22:00 πŸ‘ 7302 πŸ” 2399 πŸ’¬ 28 πŸ“Œ 98

Amazing stuff here from @goliashf.bsky.social and the RBC team! Harmonized and curated imaging and phenotype data from over 6,000 youth easily accessible without any DUA. Check it out.

24.09.2025 12:58 πŸ‘ 7 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread πŸ‘‡

www.biorxiv.org/cgi/content/...

07.09.2025 14:59 πŸ‘ 31 πŸ” 18 πŸ’¬ 1 πŸ“Œ 0

my linkedin feed has become filled with psychedelic memes and I'm connected with an OG acid kingpin.

28.08.2025 13:18 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I'm near certain sLFOs are big for psychedelics.

26.08.2025 17:14 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Since July 21st, we have a good reason to celebrate the summa cum laude Defense of the newly minted Dr. Hettwer who received her PhD from @hhu.de under the supervision of Prof. Simon Eickhoff @sbe.bsky.social with strongest support of Dr. Sofie Valk! Congratulations Meike!!!πŸ₯‚πŸ‘πŸ»πŸ₯πŸŽŠ

15.08.2025 09:07 πŸ‘ 18 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity We investigate the spatiotemporal organization of resting-state brain activity in individuals with and without major depressive disorder (MDD), identifying stable and recurring whole-brain functional ...

"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity"

www.researchsquare.com/article/rs-7...

21.08.2025 13:26 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

✨ New paper ✨ in JAMA Pediatrics! We discuss how understanding the timing ⏰ of stressful events relative to neurodevelopment can help us better identify risk factors (looking backward) and predict future psychopathology (looking forward) at the individual level
#neuroskyence #devpsych #PsychSciSky

19.08.2025 17:56 πŸ‘ 50 πŸ” 18 πŸ’¬ 0 πŸ“Œ 0

Is it possible to manipulate a high-level visual property while holding ~all low-level visual properties constant?

β€œNo!”, you say.

Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social

πŸ‡πŸ˜

19.08.2025 16:51 πŸ‘ 69 πŸ” 10 πŸ’¬ 5 πŸ“Œ 0

Thanks Parker!

18.08.2025 18:42 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!

18.08.2025 14:37 πŸ‘ 16 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0

Analiese Lahey, @pimcuijpers.bsky.social, @mathiasharrer.bsky.social, @mntj21.bsky.social, Sandeep Nayak, Eric Strain, @vandyatvandy.bsky.social, Bob Dworkin, @jcobbscott.bsky.social. @ted-satterthwaite.bsky.social, @pennlinc.bsky.social

18.08.2025 13:17 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
SYPRES The official website for the sypres initiative.

All of this and more can be easily accessed through sypres.io

Team effort with co-first author (!!!) @bsevchik.bsky.social and the rest of the SYPRES and Metapsy team who made this happen!

18.08.2025 13:17 πŸ‘ 4 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
screenshot of the dashboard home page

screenshot of the dashboard home page

In partnership with metapsy.org we built an interactive dashboard for exploring the data. Users can:
β€’ Filter studies by characteristics
β€’ Test different analysis parameters
β€’ Test moderators
β€’ Download figures and reports

Dashboard: metapsy.org/sypres/psilo...

18.08.2025 13:17 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0