Philip Rößler

Human cells for human proteins: Isotope labeling in mammalian cells in suspension for functional NMR studies In biological and biomedical research, the focus progressively moves towards difficult human proteins, which often can only be expressed in higher eukaryotic cells. Nuclear magnetic resonance (NMR) c...

Now out! Methods for isotope labeling in mammalian cells for NMR studies of difficult-to-produce proteins onlinelibrary.wiley.com/doi/full/10....

Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR A wealth of insights into the mechanisms of GPCRs have been gained from biophysical studies of thermostabilized β1 adrenergic receptors (β1AR) from tu…

New paper from the Gossert lab: Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR www.sciencedirect.com/science/arti...

Fresh off the press from the @lek-lab.bsky.social: Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation
#NMRchat
www.pnas.org/doi/10.1073/...

NMR-Based Measurements of Site-Specific Electrostatic Potentials of Histone Tails in Nucleosome Core Particles Electrostatics play a dominant role in guiding many biological processes. This is especially the case in the context of chromatin, where charge interactions modulate diverse activities such as DNA rep...

Check out Nick & @roesslph.bsky.social work on nucleosome electrostatics! More to come shortly 👀

#NMRchat

Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates The tools of structural biology have undergone remarkable advances in the past decade. These include new computational and experimental approaches tha…

HOT OFF THE PRESS!! Alex (@aimsever.bsky.social), Rashik (@rashikahmed.bsky.social) & Philip (@roesslph.bsky.social) review recent advances in biomolecular solution NMR and provide an outlook of what the future holds! Check it out here:

#NMR #NMRchat

Kay Lab is now live on 🦋

bsky.app/profile/lek-...