Maria Alcolea

Thanks so much!!

Thanks Ivan!

Thanks for featuring our work on how emerging tumour remodel their nascent niche 🌱promoting their survival @cam.ac.uk, @scicambridge.bsky.social , @cruk-ci.bsky.social, @pdncambridge.bsky.social

www.stemcells.cam.ac.uk/news/alcolea...

www.nature.com/articles/s41...

Thanks so much Francesca! 😊🙏

Thanks so much Katja! 🙏

Thanks so much Emma! I really appreciate it!🙏

Exciting time ahead!

Thanks Teresa! 🙏

Thanks Alberto!

Thanks so much Silvia!

Thank you for your contribution to this work Steffen!

Somatic genomics as a discovery engine for biomedicine Somatic mutations, or genetic changes occurring in cells after conception, are widespread in healthy tissues but are conventionally viewed as signs of…

Somatic genomics as a discovery engine for biomedicine - a Perspective in Cell
www.sciencedirect.com/science/arti...

Thanks Alejo! Yes, let's celebrate soon! 🥳

Thanks! 🙏

Thanks so much Sara!

Thanks Jesse! 🙏

Thanks!

Thanks Szen! 🙏

Thank you so much Alejo! 🙏

We are deeply grateful to our funders for their continued support including @wellcometrust.bsky.social, @royalsociety.org, @ukri.org , @worldwidecancer.bsky.social, Guts UK Charity, @cancerresearchuk.org, @erc.europa.eu.

Immense gratitude to the whole team who worked tirelessly to make this happen, especially our fantastic collaborators Ayesha Noorani, Sebastian Zeki, Jozsef Jaszai, Yiteng Dang, @rulands.bsky.social, Phil Jones, Ben D. Simons and many others.

🔬 Remarkably, this niche alone can induce tumour-like properties in otherwise normal epithelial cells.

🐭 When we blocked tumour–stromal communication, far fewer early tumours persisted.

🚶‍♂️🚶‍♀️ Surviving features are in human tumours opening new avenues for early detection 🔎 and prevention.

⚡ Surviving early tumours activate a stress response that mobilises fibroblasts. 🧱 These cells remodel the extracellular matrix, building a fibronectin-rich “pre-cancerous niche” — a wound-healing programme gone rogue — that supports tumour growth and survival.

🧬 We all accumulate mutations as we age — yet most emerging lesions are eliminated. So why do some escape?

Our study shows that the earliest tumour–stroma interactions determine whether abnormal cell clusters are cleared or allowed to persist long term.

🚨 New paper from our lab just published in Nature🚨

www.nature.com/articles/s41...

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone

✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Fantastic first day of the Stem Cell and Cancer Fusion Conference! Full of exciting science!

Amy, Leanne, Maria & Kate welcomed our #SCC25 attendees to the beautiful Malta this afternoon, a great 4 days ahead for this group, discussing all things Stem Cells & Cancer!
@joneslabucsf.bsky.social @mariapalcolea.bsky.social @katemiro.bsky.social

📢 Last chance to register!
There's still time to sign up for the FUSION Stem Cells and Cancer Conference
🗓️ Registration closes on 31st July — don’t miss out!
bit.ly/49sCfJp
Co-chairs @joneslabucsf.bsky.social, Kathrin Plath,
@katemiro.bsky.social at @fusionconf.bsky.social

⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference!
🧪Share your exciting discoveries with us!!
📍Malta
🗓️Talk Deadline: July 10
🔗http://bit.ly/49sCfJp
@joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social

Incredible line-up of speakers! Come join us for the FIRST @fusionconf.bluesky.social #Stemcells and #Cancer conference🔬!!