Severin Ronneau

Thanks Julien !

Stress-Induced Iron-Sulfur Cluster Damage as a Conserved Trigger of the Stringent Response Pathogenic bacteria rely on the stringent response to adapt to the complex and fluctuating conditions encountered within the host. However, the mechanisms by which the stringent response senses host-i...

Happy to share our lastest story about the Stringent Response ! We show how host-relevant stress disrupts Fe-S cluster stability, tuning (p)ppGpp levels to control bacterial adaptation and trigger virulence.
Read more here 👉 www.biorxiv.org/content/10.1...

Intoxication of antibiotic persisters by host RNS inactivates their efflux machinery during infection Author summary By influencing the physiology of bacterial pathogens, the host environment can either limit or potentiate the effectiveness of antibiotics during infection. Recently, we demonstrated th...

Excited to share our latest work on antibiotic persistence ! We found that while bacteria intoxicated by host RNS are shielded from β-lactams, they still remain vulnerable to fluoroquinolones. Why? Check our new study : journals.plos.org/plospathogen...

I was using the excell files these few last days but the website is so much better 👍 Thanks Jay, it is one of my favorite tool online !

The HintonLab SalCom transcriptomic databases are back on online TODAY❗️#Salmonella

SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/...

SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/...

SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/...

SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack

Highly recommend this excellent review from Katherine Cotten and Kimberly Davis about antibiotic persistence during infection. Really happy to see that we are moving forward in this challenging field !