Irfan Lodhi

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis Nature - A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for...

Last year, I submitted a grant, and two days later, I saw this @nature.com paper from @lodhilab.bsky.social coming out, which nicely supports (but doesn't scoop) the core idea of my proposal. Let's hope the reviewers keep up with the current literature! 🤞🏻
www.nature.com/artic... 🧪

The neglected organelle

Thanks so much, Katsu! It’s been an incredible journey since our Clay lab days. So glad to have you and Babak @razanilab.bsky.social as co-authors and long-time collaborators. Couldn’t have asked for better colleagues and friends along the way.

Thanks, Marc

Covariation MS uncovers a protein that controls cysteine catabolism - Nature A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...

Thanks, Farnaz!

Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...

Weight loss drugs: Utah study in mice finds 'unexpected' effects Weight loss drugs and muscle mass are at the center of a new Utah study.

Channel 2, 4, 5, and 13 as well as a few local newspapers reached out to me today regarding our study on semaglutide we published in Cell Metabolism last week.

This interview is from NBC/KSL.

Congratulations, Katsu! Look forward to reading this.

Opinion | Science Suffers With Trump’s Funding Freeze America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.

My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...

Wondered how #adipocyte #fat release #lipid via #lipolysis in #fasting, cold exposure? Multi-year Razani lab effort in @jclinical-invest.bsky.social by postdoc maven Yu-Sheng Yeh identifies #lysosome lipolysis (LAL) as major way on par with known cytosolic route (ATGL)
jci.org/articles/view/185340

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

This is as good an introduction as any - the reason why I am here. #StandUpForScience. Nice to see you all.