Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Researchers in #ScienceSignaling have discovered a signaling mechanism that prevents T helper 17 cells from adopting pathogenic states linked to #autoimmunity, potentially informing future efforts to treat autoimmune diseases such as multiple sclerosis. https://scim.ag/4mzj6tX
We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
Being open to new ideas is the only personality trait that is proven to influence creativity and discoveries.
Interesting! I wonder if these TCRs share identical nt sequences or if they are examples of convergent recombination positively selected against the same antigen(s).
Adrian Liston reported shared Treg TCRs across several tissues: doi.org/10.1016/j.im...
Not sure if he defined ntCDRs or aaCDRs
Inspiring editorial. Understanding immunity, one patient at a time. @jhumimmunity.org
rupress.org/jhi/article/...
Learning the language of T cell receptors through large-scale screening: Cancer Cell www.cell.com/cancer-cell/...
'(...) German research institute BioMed X is stepping in to offer a lifeline. The institute has opened a matchmaking program to align threatened NIH grants with potential new funders from the pharmaceutical industry.'
www.fiercebiotech.com/research/ger...
Regulatory T cells with engineered specificity for HLA-DQ2.5–restricted deamidated gluten peptides exert bystander suppression in vivo
www.science.org/doi/10.1126/...
Cool germinal center acrobatics from Juhee Pae et al, check it out!
www.nature.com/articles/s41...
Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation @natimmunol.bsky.social
www.nature.com/articles/s41...
In this review, Pilar Martín and Francisco Sánchez-Madrid describe the functions of T cells in cardiac health and disease and discuss implications for cardiac immunotherapies, with a focus on the immune receptor CD69 as a promising target: https://www.jci.org/articles/view/185218
Elucidating the role of autoreactive T cells and B cells in autoimmune hepatitis
@jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Beware one will be future you
Xin Chen, Mark Davis et al in @natimmunol.bsky.social study on human CD4+ and CD8+ Tregs using a Foxp3 KO approach in human tonsil-derived immune organoids.
#Immunology #Immunosky #organoids
www.nature.com/articles/s41...
“Just because Bluesky is at the earliest phase, before enshittification has started, doesn’t mean it won’t be enshittified.”
🌟Keystone Cancer Immunotherapy conference 2025 🌟 Speaker Highlight #2 at #KSCancerImmune25: Dr. Ton N. Schumacher @nkinl.bsky.social will discuss how T cells detect tumors in “Dissecting T Cell Recognition of Cancer.” Don’t miss his cutting-edge immunology insights!
Ants best humans at test of collective intelligence
"When people work together, they can achieve great things. But if they can’t talk, they’re not necessarily smarter than ants"
Original paper
www.pnas.org/doi/10.1073/...
News
www.science.org/content/arti...
Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors
@naturemicrobiol.bsky.social
www.nature.com/articles/s41...
‼️‼️
Last few days to apply to join us as a
#PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Human #Immunity at Lund University in #Sweden
More info on how to apply below (please RT)
Hello T cell enthusiasts! Ever tried to combine an AIM and ICS assay? If not, here is the protocol for you!
Beautiful!!
1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens
TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk
I've created a new plugin for #PyMOL (called PyMOLfold) that allows you to fold protein sequences right in the GUI. Simply select your model of choice (e.g., #ESM3, Boltz-1) and paste in your amino acid sequence.
github.com/colbyford/Py...
#ai #proteinfolding #alphafold
Preview: T-switch-ing TCR specificity
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...
Repertoire-based mapping and time-tracking of helper T cell subsets in scRNA-Seq
doi.org/10.1101/2023...
Speaker line up for #EMBOTissueImmunity to take place in Basel 🇨🇭 26-29 August 2025. Come join @maurogaya.bsky.social and I for some fantastic #immunology along the Rhine! Please share this invitation - we hope you will join us. Registrations will be open soon.
Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis
www.sciencedirect.com/science/arti...
With commentary:
Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases
www.sciencedirect.com/science/arti...
in @cellpress.bsky.social
