Great review of reproductive health in the liver transplant recipient by Dr Sarkar et al

journals.lww.com/lt/abstract/...

#liversky

Higher versus Standard Mean Arterial Pressure Target in the Immediate Postoperative Period of Liver Transplantation to Prevent Acute Kidney Injury: A Randomized Clinical Trial - (LIVER-PAM) - PubMed Acute kidney injury (AKI) is a frequent complication after liver transplantation, with incidence up to 81%, and is associated with impaired long-term renal function, graft survival, and increased mort...

MAP >65 mmHg VS higher targets to improve AKI post LT
💫 LIVER-PAM trial
📌 open-label, single-center, RCT
📌 174 adult pts randomized to MAP 85-90 mmHg or 65-70 mmHg first 24 hrs
📌 primary outcome: AKI incidence within 7 days
🔑 Did not reduce AKI incidence
#liversky
pubmed.ncbi.nlm.nih.gov/40774358/

Recompensation in decompensated cirrhosis Recompensation of decompensated cirrhosis has been defined by the Baveno consensus as control or cure of the main underlying cause; resolution of clinical manifestations, including ascites and hepatic...

New Review - Recompensation in decompensated cirrhosis

www.thelancet.com/journals/lan...

#LiverSky #MedSky

New research - Pre-emptive TIPS for gastric variceal bleeding in patients with cirrhosis (GAVAPROSEC): an open-label randomised clinical trial

www.thelancet.com/journals/lan...

#LiverSky #MedSky

Figure showing HCC incidence according to PAGE-B groups - robust risk stratification in high / intermediate / low PAGE-B

Impact of #HBV #treatment in reducing liver #cancer, #transplant and HBsAg loss over >10 year follow up.
George Papatheodoridis presenting with risk stratification.
#EASLCongress @easlnews.bsky.social

BSG 2025 Guidelines: Colorectal Surveillance in IBD

gut.bmj.com/content/earl...

@bmj.com #GISky #IBDSky

A counter-proposition for donut: I would like to volunteer as his personal chauffeur, effective immediately

Is dit de Speld undercover?

Decompensated cirrhosis: an update of the BSG/BASL admission care bundle Acute decompensated cirrhosis (DC) and acute-on-chronic liver failure are common reasons for hospital admission that have a high in-hospital mortality rate (10%–20%). Patients require a detailed asses...

Fantastic to see the updated BSG/BASL decompensated cirrhosis admission bundle in print at FG
- practical guidance to improve care in the first 24 hours as well as implementation strategy - congrats Stuart McPherson for driving this! #livertwitter

fg.bmj.com/content/earl...

Pig livers for people: US regulator greenlights first safety trial Four people with liver failure will be connected to an external organ from genetically modified pigs.

Four people with liver failure will be connected to an external organ from genetically modified pigs

https://go.nature.com/3Yv2nig

How old is this guy, 97??

Phosphatidylethanol levels distinguish steatotic liver disease subgroups and are associated with risk of major liver outcomes Phosphatidylethanol (PEth) is an ethanol metabolite used as a specific biomarker for recent alcohol consumption. We aimed to determine the proportion …

🚨New paper from us in Journal of Hepatology - Using PEth values on >50,000 persons to predict outcomes. www.sciencedirect.com/science/arti...

ADMIT-ASC index for ASUC.

Score of ≥3 was 84% predictive of steroid failure

- CRP ≥100mg/L (1 point)
- albumin ≤25g/L (1 point)
- UCEIS ≥4 (1 point) or ≥7 (2 points)

Will these pts benefit from early 'salvage' therapy instead of waiting till Day 3?

#IBDSky #GISky

gut.bmj.com/content/72/3...

Yup, he’s like the inverse of Dylan van Baarle, who is (again) absolute garbage at positioning.

I’m looking for all your liver related questions! Doing a mailbag episode dedicated to our finest organ.

Reply below, DM or send email to hopquestions@gmail.com.

No question too big or small.

Today, we screened our first patient in ECLIPSE 1 Phase 3 clinical trial (VIR) evaluating combination of tobevibart and elebsiran for HDV.

Bright future for Hepatitis Delta treatment 👌
#IDsky #Liversky

Images in Clinical Medicine Ménétrier’s Disease Panel A: CT of the abdomen Panel B: Gastroscopy

A 16-year-old girl presented with a 2-month history of leg swelling. Laboratory results were notable for a low albumin level. Abdominal CT revealed diffuse thickening of the gastric wall with enlarged gastric folds. Full case details: nej.md/441oqAJ

#MedSky #PedSky #GastroSky

A practical review of new AGA guidance on PVT management by @drjessicadavis.bsky.social
#liversky
📍don’t delay AC
📍can hold AC for EGD for 48 hours
📍AC does NOT increase risk of bleeding from varices while you wait for EGD

The current applications and future directions of... : Hepatology Communications sion-based administration compared to bolus dosing. We discuss previously reported adverse effects of terlipressin and evidence-based strategies to maximize the safety of administration. We also revie...

Everything you need to know about terlipressin

journals.lww.com/hepcomm/full...

Naltrexone in 🍷🍸🍺-associated liver disease

✅ Overall, safe for treatment of alcohol use disorder in this population

Black box warning for chronic liver disease was REMOVED in 2013: 🚫 evidence of harm

🔑 Alcohol causes harm to the liver, naltrexone does NOT

Slides: #ALD-ALLY Lamia Haque #liversky

Here is an update on the cirrhosis epidemiology in Denmark: doi.org/10.1016/j.jh...
* Median age at cirrhosis diagnosis up from 56y in 1998 to 66y in 2022
* Proportion with ALD cirrhosis down from 80% to 58%
* Prevalence of cirrhosis peaked in 2024
* Survival has improved
#Liversky

🆕CPG❕

EASL Clinical Practice Guidelines on TIPS

✅Addresses all aspects of #TIPS in patients with #cirrhosis

Full text here: bit.ly/4hZuMUK

#LiverSky
@easlnews.bsky.social

Das war einmal

Can we still trust American science, now that politics reach far into Academia? How do we deal with this?

Real-world 12 month outcomes of anti-TNF vs UST vs VDZ in ulcerative colitis.

UST group has 90% who are bio-experienced compared to VDZ and anti-TNF group (30+%), leading to:
1. High 'persistence' cos lack of options
2. 'Lower' efficacy of UST

#IBDSky #GISky

academic.oup.com/ecco-jcc/adv...

Colorectal cancer screening:
- FIT is non-inferior to colonoscopy for CRC-related deaths at 10 years

n= 57404
Participation rates higher for FIT (39.9%) vs scope (31.8%)
CRC-deaths similar: FIT (0.24%) vs scope (0.22%)

#GISky #SurgSky

@thelancet.bsky.social

www.thelancet.com/journals/lan...

🧠 AI-assisted colonoscopy detects more polyps — but does that further prevent #colorectalcancer? Our guideline published in @aga-gastro.bsky.social explores the potential and challenges of CADe systems — and why more data is needed.

Read more: gastro.org/news/new-gui...

🌟 #AI

With a heavy heart, I've decided to suspend all academic travel to the USA for me and my lab. Given the escalation of tensions and uncertainties, it seems to be the wisest move. To our US colleagues, please be certain that we will continue to do what we can to support you. Science is global.

Infections in Standard or Tapered Dose of Prednisolone for... : Official journal of the American College of Gastroenterology | ACG mary objective was to assess the incidence of infection by day 90. The key secondary objectives were the incidence of mortality, acute kidney injury (AKI), readmissions rate and adverse events. Metho...

After five decades, steroid dosing in AAH is revisited: Tapered prednisolone proves superior in reducing infections.
#STASH trial @jasmohanbajaj.bsky.social @juanpabloarab.bsky.social @ebtapper.bsky.social @tonybreu.bsky.social
@blaneymd.medsky.social
journals.lww.com/ajg/abstract... #liversky