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Zach

@zacharywalker

Asst Research Professor at University of Colorado, focused on therapy development for multiple myeloma.

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11.10.2023
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Latest posts by Zach @zacharywalker

Ribosome Profiling Reveals Translational Reprogramming via mTOR Activation in Omacetaxine-Resistant Multiple Myeloma Abstract. Protein homeostasis is critical to the survival of multiple myeloma cells. Although this is targeted with proteasome inhibitors, mRNA translation inhibition has not entered trials. Recent wo...

The latest research from our lab - utilizing ribosome profiling to investigate mechanisms of drug resistance in multiple myeloma: aacrjournals.org/mcr/article-...

19.05.2025 20:29 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma | NEJM Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma, a...

Should patients with high-risk smoldering myeloma receive daratumumab? #MyelomaSky www.nejm.org/doi/full/10....

14.12.2024 18:11 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Poster presentation

Poster presentation

Presented the results of our Phase 2 Selinexor trial at #ASH2024

11.12.2024 00:15 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy
www.nature.com/articles/s41...

29.11.2024 20:04 πŸ‘ 23 πŸ” 5 πŸ’¬ 0 πŸ“Œ 3
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A Combinatorial Functional Precision Medicine Platform for Rapid Therapeutic Response Prediction in AML The Quadratic Phenotypic Optimization Platform (QPOP) allows for the analysis of patient-specific combinatorial drug sensitivities without prior genetic testing in a rapid manner compared to standard...

Interesting approach to ex vivo drug screening in AML, out this week in Cancer Medicine: A Combinatorial Functional Precision Medicine Platform for Rapid Therapeutic Response Prediction in AML
onlinelibrary.wiley.com/doi/10.1002/...

23.11.2024 15:10 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

What an achievement vaccines are. What a monument to our love for each other it is to stare straight into the face of something as horrific and unstoppable as smallpox or measles or polio or cervical cancer and say β€œYou know what, it doesn’t have to be like this.”

HUMANS!

15.11.2024 01:59 πŸ‘ 25000 πŸ” 2753 πŸ’¬ 226 πŸ“Œ 85